Review of the in vitro and in vivo genotoxicity of dichlorvos

Booth, Ewan D.; Jones, E. W.; Elliott, B.M.

doi:10.1016/j.yrtph.2007.08.011

Cited by 35 publications

(25 citation statements)

References 60 publications

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“…The genotoxicity evaluations have included a wide range of test systems and endpoints including assays both in vitro and in vivo. There is general agreement that DDVP is genotoxic in vitro (Booth et al, 2007). Literature also cites DDVP toxicity to humans which includes dose-dependent decrease in human erythrocyte cholinesterase activity and sperm motility based on the urinary concentration of dimethyl phosphate, a urine metabolite of DDVP (Okamura et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Protective role of vitamins C and E in diclorvos-induced oxidative stress in human erythrocytes in vitro

et al. 2013

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Organophosphate (OP) pesticides such as dichlorvos (DDVP) intoxication has been shown to produce oxidative stress due to the generation of free radicals, which alter the antioxidant defense system in erythrocytes. In this study, the eff ects of DDVP (1, 10, 100 μM) or DDVP + vitamin C (VC; 10 μM) or vitamin E (VE; 30 μM), on the levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities in human erythrocytes were examined in vitro. There were no statistical diff erences between all groups for 1 μM concentration of DDVP. Treatment with DDVP alone produced an increase in the level of MDA and decreased activities of antioxidant enzymes (P < 0.05). Groups treated with vitamins and DDVP showed protective eff ects of vitamins against DDVP-induced changes in antioxidant enzyme activity and lipid peroxidation (LPO) (10 μM). At 100 μM concentration of DDVP vitamins had no eff ect on DDVP-induced toxicity. The results show that administration of DDVP resulted in the induction of erythrocyte LPO and alterations in antioxidant enzyme activities, suggesting that reactive oxygen species (ROS) may be involved in the toxic eff ects of DDVP. Also the data show that the plasma level of VC and VE may ameliorate OP-induced oxidative stress by decreasing LPO in erythrocytes at certain doses of OP pesicides.

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Section: Introductionmentioning

confidence: 99%

Protective role of vitamins C and E in diclorvos-induced oxidative stress in human erythrocytes in vitro

et al. 2013

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“…This may result in DDVP residues being encountered in groundwater, river and lake waters and also in coastal waters (Touraj et al, 2011). Therefore, the residue of DDVP might ultimately enter into the human system through consumption of agriculture and aquatic food and by drinking water, thereby causing certain damage to human health (Booth et al, 2007). In recent years, a number of studies have been carried out for assessing the environmental risk of DDVP pesticide in some species (Darko et al, 2008;Ning et al, 2012;Nurullah et al, 2010;Ural and Calta, 2005).…”

Section: Discussionmentioning

confidence: 99%

Toxicity effect of dichlorvos on loach (Misgurnus anguillicaudatus) assessed by micronucleus test, hepatase activity analysis and comet assay

Peng

Yan

et al. 2013

Toxicol Ind Health

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Pesticides and other chemicals at environmental concentrations often have detrimental effects. Many aquatic species are particularly threatened because of their susceptibility and also because water environment are often polluted. This study preliminarily evaluated the toxicity effect of dichlorvos (DDVP) on loach (Misgurnus anguillicaudatus) using the methods of micronucleus (MN) test, hepatase activity and comet assay. The tested results showed that indeed very little DDVP had strong toxicity effect on loach and its 50% lethal concentration (LC50) at 24 h, 48 h and 96 h was 8.38 μg l(-1), 7.168 μg l(-1) and 6.411 μg l(-1), respectively; The glutamic-pyruvic transaminase (GPT) and glutamic-oxalacetic transaminase (GOT) activity of loach liver decreased; meanwhile, the GPT and GOT activity of loach serum, the MN rate (‰) and three comet parameters of tested fish increased with the increase in the treatment concentration and treatment time of DDVP, and there was significant difference between control group and each treatment group (p < 0.05). These results suggested that DDVP residues might become toxic chemical contaminant in environment and would threaten aquatic and other organisms.

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“…Hydrolysis is the main metabolic route in mammals (Booth et al 2007). In the environment, dichlorvos degenerates rapidly by biotic and abiotic processes to metabolites including dichloroacetic acid, dimethylphosphate, and dichloroethanol (WHO 2007).…”

Section: Dichlorvosmentioning

confidence: 99%

“…In vitro genotoxicity of this pesticide has been demonstrated. However, it has been shown that in vivo exposure at environmental concentrations demonstrates little genotoxicity (Booth et al 2007). In the few studies reviewed which involved in vivo genotoxicity at environmental levels, concerns were expressed regarding methodology.…”

Section: Toxic Effectsmentioning

confidence: 99%

A review of endosulfan, dichlorvos, diazinon, and diuron – pesticides used in Jamaica

Barrett

Jaward

2012

International Journal of Environmental Health Research

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Review of the in vitro and in vivo genotoxicity of dichlorvos

Cited by 35 publications

References 60 publications

Protective role of vitamins C and E in diclorvos-induced oxidative stress in human erythrocytes in vitro

Protective role of vitamins C and E in diclorvos-induced oxidative stress in human erythrocytes in vitro

Toxicity effect of dichlorvos on loach (Misgurnus anguillicaudatus) assessed by micronucleus test, hepatase activity analysis and comet assay

A review of endosulfan, dichlorvos, diazinon, and diuron – pesticides used in Jamaica

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