“…Porcine skin, in terms of dermal thickness, papillary structure, collagen composition, and distribution of dermal blood vessels, is the most comparable to humans among animal models currently used to study wound healing, including rodents, rabbits, and mini and large pigs. 11 Clinically, BM-MSCs have been shown to be safe and potentially efficacious in several phase I, II, and III clinical trials for a variety of diseases including myocardial infarction, chronic obstructive pulmonary disease, Crohn's disease, diabetes mellitus type 1, and stroke. 12 This wealth of clinical data on the safety of BM-derived MSCs warrants considering the use of these cells, as well as adipose-derived MSCs, in a wider range of applications, including wound repair.…”