Mesenchymal Stem Cells: A Multimodality Option for Wound Healing

Hanson, Summer E.

doi:10.1089/wound.2011.0297

Cited by 15 publications

(14 citation statements)

References 20 publications

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“…Paracrine tissue support and immunomodulation by MSCs are imperative during acute tissue injury, and these occur in a tissue‐specific manner in vivo . Liver regeneration involves numerous tissue growth factors and cytokines .…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal stem cells prolong survival and prevent lethal complications in a porcine model of fulminant liver failure

Lin

Wu²,

Ho³

et al. 2019

Xenotransplantation

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Background Fulminant liver failure (FLF) is a life‐threatening disease. Methods Lethal FLF was induced by ischemia‐reperfusion (I‐R) injury in mini‐pigs, and MSCs were infused via splenic vein after reperfusion. Results Accumulated survival within 28 days was significantly improved by MSCs (P = 0.0348). Notably, MSCs maintained blood‐gas homeostasis in the first 24 hours and prevented FLF‐induced elevation of prothrombin time, international normalized ratio, and creatinine and ammonia levels in the first 3 days. With MSCs, serum levels of liver enzymes gradually decreased after 3 days, and platelet count was back to normal at 1 week of FLF. MSCs promoted liver regeneration within 2 weeks and differentiated into functional hepatocytes at 2‐4 weeks after transplantation, evidenced by increase in Ki67‐positive cells, detectable human hepatocyte growth factor, human vascular endothelial growth factor, human hepatocyte‐specific antigen, and human albumin‐expressing cells in the liver at different time points. Reactive oxidative species (ROS) were accumulated after FLF and eliminated at 4 weeks after MSC transplantation. Conclusions Together, MSCs prolong the survival and prevent lethal sequelae of I‐R injury‐induced FLF by maintenance of liver‐function homeostasis and rescue of ROS in the acute stage and by homing and differentiation into hepatocytes in the subacute stage.

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Section: Discussionmentioning

confidence: 99%

Mesenchymal stem cells prolong survival and prevent lethal complications in a porcine model of fulminant liver failure

Lin

Wu²,

Ho³

et al. 2019

Xenotransplantation

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“…In order to improve the efficacy of dermal scaffolds, the application of MSCs on the material has been suggested13. MSCs have shown vast regenerative capabilities in different tissue defects including non-healing wounds14. Thus, the combined use of MSC-seeded scaffolds is a matter of intense research in the field of tissue engineering and regeneration.…”

mentioning

confidence: 99%

VEGF released by deferoxamine preconditioned mesenchymal stem cells seeded on collagen-GAG substrates enhances neovascularization

Wahl

Schenck

Machens

et al. 2016

Sci Rep

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Hypoxia preconditioning of mesenchymal stem cells (MSCs) has been shown to promote wound healing through HIF-1α stabilization. Preconditioned MSCs can be applied to three-dimensional biomaterials to further enhance the regenerative properties. While environmentally induced hypoxia has proven difficult in clinical settings, this study compares the wound healing capabilities of adipose derived (Ad) MSCs seeded on a collagen-glycosaminoglycan (GAG) dermal substrate exposed to either environmental hypoxia or FDA approved deferoxamine mesylate (DFO) to stabilize HIF-1α for wound healing. The release of hypoxia related reparative factors by the cells on the collagen-GAG substrate was evaluated to detect if DFO produces results comparable to environmentally induced hypoxia to facilitate optimal clinical settings. VEGF release increased in samples exposed to DFO. While the SDF-1α release was lower in cells exposed to environmental hypoxia in comparison to cells cultured in DFO in vitro. The AdMSC seeded biomaterial was further evaluated in a murine model. The implants where harvested after 1 days for histological, inflammatory, and protein analysis. The application of DFO to the cells could mimic and enhance the wound healing capabilities of environmentally induced hypoxia through VEGF expression and promises a more viable option in clinical settings that is not merely restricted to the laboratory.

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“…MSCs can be obtained from adipose tissue that represents an accessible source of adult stem cells with the ability to differentiate along multiple lineage pathways. 10,11 Some medical centers are already implementing adiposederived stem cells in the treatment of degenerative diseases. For instance, Okyanos Cell Therapy (Freeport, Grand bahama) is reintroducing autologous adipose-derived stem cells in the management of orthopedic, neurologic, and cardiac conditions, as well as chronic wounds, with meaningful success.…”

Section: Simonimentioning

confidence: 99%

“…2,3 The authors' conclusion that their wound treatment method with MSCs to promote tissue regeneration in skin injuries is well founded, clinically important and in line with numerous reports. 10,11 Although this stem cell-scaffold concept in wound healing is not yet accepted as the standard of care and remains at the experimental stage, many stem cell secreted factors have been isolated and used in treatment, particularly in nonhealing wounds.…”

Section: Simonimentioning

confidence: 99%

Employing Mesenchymal Stem Cells in Wound Care

Simoni¹

2015

ASAIO Journal

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Mesenchymal Stem Cells: A Multimodality Option for Wound Healing

Cited by 15 publications

References 20 publications

Mesenchymal stem cells prolong survival and prevent lethal complications in a porcine model of fulminant liver failure

Mesenchymal stem cells prolong survival and prevent lethal complications in a porcine model of fulminant liver failure

VEGF released by deferoxamine preconditioned mesenchymal stem cells seeded on collagen-GAG substrates enhances neovascularization

Employing Mesenchymal Stem Cells in Wound Care

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