Review of the effects of vitexin in oxidative stress‐related diseases

Babaei, Fatemeh; Moafizad, Armita; Darvishvand, Zahra; Mirzababaei, Mohammadreza; Hosseinzadeh, Hossein; Nassiri‐Asl, Marjan

doi:10.1002/fsn3.1567

Cited by 72 publications

(58 citation statements)

References 69 publications

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“…This compound was also found in CLEE‐DC1 and was the most abundant compound in this extract (11.4 X10 6 ). Vitexin and isovitexin have been extracted from several medicinal plants and showed a remarkable biological activities including antioxidant, antimicrobial, and anticancer activities (Babaei et al., 2020; He et al., 2016; Khole et al., 2016). Kaempferol derivatives were detected in both extracts; however, BLEE‐DC1 possessed the higher abundance.…”

Section: Resultsmentioning

confidence: 99%

Ethanolic extract of Betel ( Piper betle L.) and Chaphlu ( Piper sarmentosum Roxb.) dechlorophyllized using sedimentation process: Production, characteristics, and antioxidant activities

Tagrida

Benjakul

2020

J. Food Biochem.

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Sedimentation process was used to remove chlorophyll from betel leaf ethanolic extracts (BLEE) and chaphlu leaf ethanolic extracts (CLEE). The influence of water quantity on chlorophyll content, total phenolic content (TPC), and antioxidant activity of the extracts was studied. The sedimentation process showed a remarkable reduction in chlorophyll A, chlorophyll B, and total chlorophyll contents of both extracts. Nevertheless, no differences in chlorophyll content, TPC, and antioxidant activities were observed between dechlorophyllized fractions in both extracts (p > .05). Liquid Chromatography-Mass Spectrometry (LC/MS) profiling showed that the BLEE dechlorophyllized using the extract/water ratio of 1:1 (BLEE-DC1) had higher phenolic compounds than CLEE-DC1. Isovitexin was the most abundant compound identified in the BLEE-DC1 while vitexin 4′-O-galactoside was the most prevalent in CLEE-DC1. When thermal and pH stabilities of the dechlorophyllized extracts were tested, BLEE-DC1 exhibited more heat stability (at 60-100°C for 0-60 min) than CLEE-DC1. Both dechlorophyllized extracts showed optimum antioxidant activities at pH 5.0. Practical applications Oxidation process is associated with the numerous human diseases as well as it induces the deteriorative changes in foods, especially those rich in fat or lipid containing high polyunsaturated fatty acids. Numerous synthetic antioxidants have been employed but they may not be safe. Natural antioxidants have gained attention, particularly those from several leaves rich in polyphenols. However, due to the green color caused by chlorophylls, the extract is limited for further applications. Betel leaf ethanolic extract possessing high antioxidant activity could be dechlorophyllized using sedimentation process with the appropriate proportion of water. This green process not only showed the effective removal of chlorophyll, but also increased the proportion of polyphenol in the extract. Greenless betel leaf extract with augmented antioxidant activity can be used as natural additive to replace synthetic counterpart. K E Y W O R D S antioxidant activities, betel leaf extract, chaphlu leaf extract, chlorophyll removal, LC/MS, sedimentation | 3 of 14 TAGRIDA AnD BEnJAKUL were thoroughly washed with tap water and dried in a hot air oven at 50°C overnight until moisture content of the leaves was less than 10%. Dried samples were blended, and then, sieved using 80 mesh stainless-steel sieve. The obtained powder named as "betel leaf

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Section: Resultsmentioning

confidence: 99%

Ethanolic extract of Betel ( Piper betle L.) and Chaphlu ( Piper sarmentosum Roxb.) dechlorophyllized using sedimentation process: Production, characteristics, and antioxidant activities

Tagrida

Benjakul

2020

J. Food Biochem.

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“…It is well‐known that natural products are important sources of neuroprotective agents (Babaei et al., 2020; Koushki, Amiri‐Dashatan, Ahmadi, Abbaszadeh, & Rezaei‐Tavirani, 2018). In the present study, we determined the neuroprotective effect and the underlying mechanisms of extract in CNC leaves.…”

Section: Resultsmentioning

confidence: 99%

Neuroprotective effects of Camellia nitidissima Chi leaf extract in hydrogen peroxide‐treated human neuroblastoma cells and its molecule mechanisms

Liu

Zhang

et al. 2020

Food Science & Nutrition

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Camellia nitidissima Chi (CNC) is a famous medicinal and edible plant with the name of “Tea for Longevity” in Guangxi province of China. In present study, we determined the protective effect of extract from CNC leaves on H2O2‐induced cell injury and its underlying mechanisms in human neuroblastoma (SH‐SY5Y) cells. The ethyl acetate fraction of CNC leaves (CLE, 50–200 μg/ml) treatment significantly increased the cell viability of H2O2‐treated SH‐SY5Y cells and reduced the leakage of LDH in a reversed “U”‐shape manner. It was confirmed by Hoechst 33,342 staining that CLE attenuated H2O2‐induced apoptosis in SH‐SY5Y cells. The CLE (100 and 150 μg/ml) treatment significantly relieved H2O2‐induced oxidative stress by decreasing intracellular ROS level, and increasing the activities of superoxide dismutase (SOD) and catalase (CAT). Western blot analysis demonstrated that the CLE treatment reserved H2O2‐induced decrease of pCREB (Ser133) expression, and its downstream protein BDNF. In addition, 37 phenolic compounds in CLE were identified by UPLC‐TOF MS/MS, and the main active phytochemicals seemed to be catechins, quercetin, kaempferol, and their derivatives. In conclusion, the data analysis showed that the neuroprotective effect of CNC leaves might be achieved via synergistically boosting endogenous antioxidant defenses and neurotrophic signaling pathway. These results suggest that CNC leaves are valuable resources for functional foods and beverages.

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“…Vitexin is an apigenin flavone glycoside naturally available in hawthorn berry, mung beans, bamboo, buckwheat, echinodorus, and passiflora [116]. It is a primary polyphenolic compound of mung beans [117].…”

Section: Vitexinmentioning

confidence: 99%

A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes

Akter

Afrose

Rahman³

et al. 2021

IJMS

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Natural products have long been used as drugs to treat a wide array of human diseases. The lead compounds discovered from natural sources are used as novel templates for developing more potent and safer drugs. Natural products produce biological activity by binding with biological macromolecules, since natural products complement the protein-binding sites and natural product–protein interactions are already optimized in nature. Sirtuin 6 (SIRT6) is an NAD+ dependent histone deacetylase enzyme and a unique Sirtuin family member. It plays a crucial role in different molecular pathways linked to DNA repair, tumorigenesis, glycolysis, gluconeogenesis, neurodegeneration, cardiac hypertrophic responses, etc. Thus, it has emerged as an exciting target of several diseases such as cancer, neurodegenerative diseases, aging, diabetes, metabolic disorder, and heart disease. Recent studies have shown that natural compounds can act as modulators of SIRT6. In the current review, a list of natural products, their sources, and their mechanisms of SIRT6 activity modulation has been compiled. The potential application of these naturally occurring SIRT6 modulators in the amelioration of major human diseases such as Alzheimer’s disease, aging, diabetes, inflammation, and cancer has also been delineated. Natural products such as isoquercetin, luteolin, and cyanidin act as SIRT6 activators, whereas vitexin, catechin, scutellarin, fucoidan, etc. work as SIRT6 inhibitors. It is noteworthy to mention that quercetin acts as both SIRT6 activator and inhibitor depending on its concentration used. Although none of them were found as highly selective and potent modulators of SIRT6, they could serve as the starting point for developing selective and highly potent scaffolds for SIRT6.

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Review of the effects of vitexin in oxidative stress‐related diseases

Cited by 72 publications

References 69 publications

Ethanolic extract of Betel ( Piper betle L.) and Chaphlu ( Piper sarmentosum Roxb.) dechlorophyllized using sedimentation process: Production, characteristics, and antioxidant activities

Ethanolic extract of Betel ( Piper betle L.) and Chaphlu ( Piper sarmentosum Roxb.) dechlorophyllized using sedimentation process: Production, characteristics, and antioxidant activities

Neuroprotective effects of Camellia nitidissima Chi leaf extract in hydrogen peroxide‐treated human neuroblastoma cells and its molecule mechanisms

A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes

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