2020
DOI: 10.1002/fsn3.1742
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Neuroprotective effects of Camellia nitidissima Chi leaf extract in hydrogen peroxide‐treated human neuroblastoma cells and its molecule mechanisms

Abstract: Camellia nitidissima Chi (CNC) is a famous medicinal and edible plant with the name of “Tea for Longevity” in Guangxi province of China. In present study, we determined the protective effect of extract from CNC leaves on H2O2‐induced cell injury and its underlying mechanisms in human neuroblastoma (SH‐SY5Y) cells. The ethyl acetate fraction of CNC leaves (CLE, 50–200 μg/ml) treatment significantly increased the cell viability of H2O2‐treated SH‐SY5Y cells and reduced the leakage of LDH in a reversed “U”‐shape … Show more

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Cited by 16 publications
(12 citation statements)
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“…This treatment reduces the effects of diabetes on nNOS-IR neurons and VIP-IR varicosities in the myenteric plexus of experimental diabetic rats, as reported by Martins-Perles et al [87]. The presence of quercetin in Camellia nitidissima Chi, 'Tea for Longevity' a well-known plant consumed as both medicine and food in China, was studied for its neuroprotective effect by An et al [88]. Based on two used terms, 'synergistically boosting endogenous antioxidant defences' and 'neurotrophic signalling pathway' by An et al [88], this plant has been cited as an important source for phytonutrients, including quercetin for edible foods and beverages.…”
Section: Quercetin As a Neuroprotective Agentmentioning
confidence: 86%
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“…This treatment reduces the effects of diabetes on nNOS-IR neurons and VIP-IR varicosities in the myenteric plexus of experimental diabetic rats, as reported by Martins-Perles et al [87]. The presence of quercetin in Camellia nitidissima Chi, 'Tea for Longevity' a well-known plant consumed as both medicine and food in China, was studied for its neuroprotective effect by An et al [88]. Based on two used terms, 'synergistically boosting endogenous antioxidant defences' and 'neurotrophic signalling pathway' by An et al [88], this plant has been cited as an important source for phytonutrients, including quercetin for edible foods and beverages.…”
Section: Quercetin As a Neuroprotective Agentmentioning
confidence: 86%
“…The presence of quercetin in Camellia nitidissima Chi, 'Tea for Longevity' a well-known plant consumed as both medicine and food in China, was studied for its neuroprotective effect by An et al [88]. Based on two used terms, 'synergistically boosting endogenous antioxidant defences' and 'neurotrophic signalling pathway' by An et al [88], this plant has been cited as an important source for phytonutrients, including quercetin for edible foods and beverages. Soxhlet extraction to yield quercetin along with other phytoconstituents from Pinus roxburghii Sarg.…”
Section: Quercetin As a Neuroprotective Agentmentioning
confidence: 99%
“…Camellia euphlebia Merr. ex Sealy (genus Camellia ), praised as “flora panda,” is not only a rare ornamental species limitedly distributed in Southwest China and Northern Vietnam but also a novel food source authorized by the Chinese Ministry of Health [ 4 , 5 ]. The great potential of C. euphlebia , either in respect of traditional folk medicine (urinary tract infection, dysentery, faucitis, and irregular menstruation) or modern pharmacological findings (antitumor, hypolipidemic, antidepressant, and antioxidant), has attracted considerable attention worldwide as a valuable resource for natural drugs [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…In addition to offering functional benefits to the community via non-pharmacological and lifestyle adaptations, it has been discovered to exert a wide range of pharmacological effects. It can be an useful agent with anticancer, antioxidant, hypolipidemic, antidiabetic, antiallergic, antibacterial, and anxiolytic properties ( He et al, 2017 ; An et al, 2020 ). Previous research study has shown that C.nitidissima has neuroprotective benefits through a synergistic interaction between antioxidant and neurotrophic signaling pathways ( An et al, 2020 ).…”
Section: Introductionmentioning
confidence: 99%