Abstract:Surface plasmon resonance biosensors are drawing attention
due
to their real-time, label-free, and rapid characteristic. To detect
trace biomarkers (ct-DNA, mi-RNA, PD-L1), plasmonic and metal oxide
nanoparticles have been utilized for signal amplification and have
shown exciting results. To achieve uniform, reproducible, simple,
and sensitive sensor interface construction, two-dimensional materials
such as graphene and molybdenum sulfide have opened a research upsurge
and show a great possibility in the surfa… Show more
“…Different from 0D and 1D materials, which have special monomer shape in micro, 2D materials are mainly used in the form of coating and stacking into layers. [203][204][205][206][207][208][209] Therefore, the following will focus on the design of sensing layer structure used with different 2D materials, rather than the microstructure of 2D materials themselves.…”
Resonance optical fiber sensors are widely studied for their high sensitivity, small size, and anti-electromagnetic interference. However, traditional resonance optical fiber sensors have encountered bottlenecks in the trace detection due to limited localized field intensity and low molecules affinity. With the development of materials technology, low-dimensional materials such as quantum dots, graphene, and transition metal sulfides have excellent properties such as high carrier mobility, large specific surface area, and flexible structure controllable artificial technologies that can also be used to synthesize new materials with desired characteristics, which can enhance the performance of sensors fundamentally. The introduction of low-dimensional materials can not only achieve the performance optimization of sensors, but also make sensors functional to realize the diversification of detection objects. This paper reviews the research progress of resonance optical fiber sensors based on low-dimensional materials. The detection principle and performance indexes related to resonance optical fiber sensing are elaborated, and resonance optical fiber sensors modified by low-dimensional materials are introduced. Furthermore, the role of low-dimensional materials in resonance fiber sensing is summarized, the direction of performance optimization in the production process of resonance fiber sensors is analyzed, and the future prospect of new resonance optical fiber sensors is given.
“…Different from 0D and 1D materials, which have special monomer shape in micro, 2D materials are mainly used in the form of coating and stacking into layers. [203][204][205][206][207][208][209] Therefore, the following will focus on the design of sensing layer structure used with different 2D materials, rather than the microstructure of 2D materials themselves.…”
Resonance optical fiber sensors are widely studied for their high sensitivity, small size, and anti-electromagnetic interference. However, traditional resonance optical fiber sensors have encountered bottlenecks in the trace detection due to limited localized field intensity and low molecules affinity. With the development of materials technology, low-dimensional materials such as quantum dots, graphene, and transition metal sulfides have excellent properties such as high carrier mobility, large specific surface area, and flexible structure controllable artificial technologies that can also be used to synthesize new materials with desired characteristics, which can enhance the performance of sensors fundamentally. The introduction of low-dimensional materials can not only achieve the performance optimization of sensors, but also make sensors functional to realize the diversification of detection objects. This paper reviews the research progress of resonance optical fiber sensors based on low-dimensional materials. The detection principle and performance indexes related to resonance optical fiber sensing are elaborated, and resonance optical fiber sensors modified by low-dimensional materials are introduced. Furthermore, the role of low-dimensional materials in resonance fiber sensing is summarized, the direction of performance optimization in the production process of resonance fiber sensors is analyzed, and the future prospect of new resonance optical fiber sensors is given.
“…Please note that this review does not include SPR- or silicon-photonic-based FOEW biosensors. In those biosensors, the detection of targets is achieved by measuring the refractive index changes, instead of fluorescence intensity changes [ 19 , 20 , 21 ].…”
Biosensors capable of onsite and continuous detection of environmental and food pollutants and biomarkers are highly desired, but only a few sensing platforms meet the “2-SAR” requirements (sensitivity, specificity, affordability, automation, rapidity, and reusability). A fiber optic evanescent wave (FOEW) sensor is an attractive type of portable device that has the advantages of high sensitivity, low cost, good reusability, and long-term stability. By utilizing functional nucleic acids (FNAs) such as aptamers, DNAzymes, and rational designed nucleic acid probes as specific recognition ligands, the FOEW sensor has been demonstrated to be a general sensing platform for the onsite and continuous detection of various targets ranging from small molecules and heavy metal ions to proteins, nucleic acids, and pathogens. In this review, we cover the progress of the fluorescent FNA-based FOEW biosensor since its first report in 1995. We focus on the chemical modification of the optical fiber and the sensing mechanisms for the five above-mentioned types of targets. The challenges and prospects on the isolation of high-quality aptamers, reagent-free detection, long-term stability under application conditions, and high throughput are also included in this review to highlight the future trends for the development of FOEW biosensors capable of onsite and continuous detection.
“…Surface plasmon resonance (SPR) has become a major research topic in the field of optical biosensors and has led to many fundamental research and applications for new optical devices based on surface plasmon polaritons. − SPR is a collective oscillation of free electrons in a metal when optical and electromagnetic waves are coupled and propagate along the interface between the metal and a dielectric. In the metal–dielectric interface, the attenuated total reflection (ATR) induces the evanescent wave, which is one of the conventional methods of SPR excitation. − The evanescent wave is generated when the p-polarized light (TM mode) enters at an angle greater than the critical ATR angle (θ 0 > θ c ) in the metal–dielectric interface.…”
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