Review About Ginkgo Biloba Special Extract EGb 761 (Ginkgo)

Gertz, H.-J.; Kiefer, M.

doi:10.2174/1381612043386437

Cited by 107 publications

(11 citation statements)

References 9 publications

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“…Although several biologically active components have been described in the literature, the predominant pharmacologically active components in Ginkgo biloba include flavonols and terpene trilactones 9 , 10 . However, the therapeutic effects EGb are likely not attributed to any one compound but rather the combined effect of several components in the whole extract 11 , 12 . Several commercialized Ginkgo biloba extracts exist but the EGb 761 extract is by the well-standardized product.…”

Section: Introductionmentioning

confidence: 99%

Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice

Rhee¹,

Lee²,

Kim³

et al. 2015

Int. J. Med. Sci.

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Diabetes mellitus (DM) is caused by either destruction of pancreatic β-cells (type 1 DM) or unresponsiveness to insulin (type 2 DM). Conventional therapies for diabetes mellitus have been developed but still needs improvement. Many diabetic patients have complemented conventional therapy with alternative methods including oral supplementation of natural products. In this study, we assessed whether Ginkgo biloba extract (EGb) 761 could provide beneficial effects in the streptozotocin-induced type 1 DM and high-fat diet-induced type 2 DM murine model system. For the type 1 DM model, streptozotocin-induced mice were orally administered EGb 761 for 10 days prior to streptozotocin injection and then again administered EGb 761 for an additional 10 days. Streptozotocin-treated mice administered EGb 761 exhibited lower blood triglyceride levels, lower blood glucose levels and higher blood insulin levels compared to streptozotocin-treated mice. Furthermore, liver LPL and liver PPAR-α were increased whereas IL-1β and TNF-α were decreased in streptozotocin-injected mice treated with EGb 761 compared to mice injected with streptozotocin alone. For the type 2 DM model, mice were given high-fat diet for 60 days and then orally administered EGb 761 every other day for 80 days. We found that mice given a high-fat diet and EGb 761 showed decreased blood triglyceride levels, increased liver LPL, increased liver PPAR-α and decreased body weight compared to mice given high-fat diet alone. These results suggest that EGb 761 can exert protective effects in both type 1 and type 2 DM murine models.

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Section: Introductionmentioning

confidence: 99%

Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice

Rhee¹,

Lee²,

Kim³

et al. 2015

Int. J. Med. Sci.

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“…EGb761 is a compound extracted from Ginko biloba leafs that consists of two active components; a flavonoid glycoside and terpene lactone20. The toxicological and pharmacological properties of EGb761 are well - characterized.…”

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confidence: 99%

Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings

Xiong

Zhang

et al. 2017

Sci Rep

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This study aimed to investigate the protective effects of EGb761, a Ginkgo Biloba extract, against brain death-induced kidney injury. Sixty male Sprague Dawley rats were randomly divided into six groups: sham, brain-death (BD), BD + EGb b48h (48 hours before BD), BD + EGb 2 h (2 hours after BD), BD + EGb 1 h, and BD + EGb 0.5 h. Six hours after BD, serum sample and kidney tissues were collected for analyses. The levels of blood urea nitrogen (BUN) and serum creatinine significantly elevated in the BD group than in sham group. In all the EGb761-treated BD animals except for the BD + Gb 2 h group, the levels of BUN and serum creatinine significantly reduced (all P < 0.01). EGb761 attenuated tubular injury and lowered the histological score. In addition, the longer duration of drug treatment was, the better protective efficacy could be observed. EGb761 significantly reduced IL-1β, IL-6, TNF-α, MCP-1, IP-10 mRNA expression and macrophage infiltration in the kidney. EGb761 treatment at 48 hour before brain death significantly attenuate the levels of p-JNK-MAPK, p-p38-MAPK, and p-STAT3 proteins (all P < 0.05, compared to BD group). In summary, our data showed that EGb761 treatment protected donor kidney from BD-induced damages by blocking SAPK and JAK-STAT signalings. Early administration of EGb761 can provide better protective efficacy.

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“…PAF causes inflammation, contracts smooth muscles, and increases the permeability of vessel walls. 7 Ginkgo is one of the most studied medicinal plants since its is used for ages and marketed widely all around the world. [8][9][10][11] As ginkgo has remarkable therapeutic indications, it has been the subject of many research.…”

Section: Derleme Reviewmentioning

confidence: 99%

Therapeutic Applications of Ginkgo biloba L. Tree: Systemic Review

ÖZTÜRK¹,

Sarı²

2023

J Lit Pharm Sci

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Ginkgo biloba L., commonly known as ginkgo, is one of the oldest trees in the world that it often referred as "living fossil" and is the only species survived from Ginkgoaceae. 1 G. biloba L. is a plant that originated in China and has been cultivated in Asia. Ginkgo thrives in full sun and moderate, mediummoisture soil. 2 One of the most notable aspects is the leaves of G. biloba L., they are distinguished by their fan form and dichotomous venation. 3 G. biloba L. female plants produce orange apricot-like structures that are not technically fruits. They are seeds that have a soft, fleshy shell section called sarcotesta and a hard section called sclerotesta. The odor of the sarcotesta is powerful and foul-smelling, and most peo-

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Review About Ginkgo Biloba Special Extract EGb 761 (Ginkgo)

Cited by 107 publications

References 9 publications

Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice

Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice

Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings

Therapeutic Applications of Ginkgo biloba L. Tree: Systemic Review

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