From the subaerial parts of S. tomentosa L. (Asteraceae), two new dihydroisocoumarins, compounds 1 and 2, a new phthalide, 3, and a new stilbene derivative, 4, were isolated, together with four known compounds, (AE)-hydrangenol (5), (À)-hydrangenol 4'-O-b-glucoside (6), (AE)-hydramacrophyllol A (7), and (AE)-hydramacrophyllol B (8). All secondary metabolites were identified on the basis of physicochemical, spectroscopic, and mass-spectrometric data. The known compounds 5 -8 were isolated for the first time from this species.
Phytochemical composition of ethyl acetate fraction and total phenolic content, in vitro antioxidant, anti-inflammatory, antimicrobial activities of petroleum ether, chloroform, ethyl acetate and n-butanol fractions of the ethanol extract obtained from the subaerial parts of Scorzonera pygmaea Sibth. & Sm. (Asteraceae) were investigated. Nine compounds; scorzopygmaecoside (1), scorzonerol (2), cudrabibenzyl A (3), thunberginol C (4), scorzocreticoside I (5) and II (6), chlorogenic acid (7), chlorogenic acid methyl ester (8), 3,5-di-O-caffeoylquinic acid (9) were isolated and identified using spectroscopic methods. All substances were isolated for the first time from this species.Compounds 1 and 2 are new. The fractions showed high antioxidant capacity correlated with their phenolic content and no significant antimicrobial activity against tested bacteria and fungi. COX inhibition test was used to evaluate the anti-inflammatory activity and all the fractions showed low inhibition in comparison with indomethacin.
A phytochemical investigation of Scorzonera veratrifolia Fenzl (Asteraceae) yielded two new 3-benzylphthalides, scorzoveratrin (1) and scorzoveratrozit (2), together with five known compounds, chlorogenic acid (3), chlorogenic acid methyl ester (4), cryptochlorogenic acid (5), 4,5-dicaffeoylquinic acid (6) and 3,5-dicaffeoylquinic acid (7). All secondary metabolites were assigned using physicochemical and spectroscopic data. The known compounds 3-7 were isolated for the first time from this species.
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