Reversine increases the plasticity of lineage-committed preadipocytes to osteogenesis by inhibiting adipogenesis through induction of TGF-β pathway in vitro

Park, Jeong Geun; Lee, Dae-Hee; Moon, Yeonsil; Kim, Kee‐Hong

doi:10.1016/j.bbrc.2014.02.036

Cited by 22 publications

(20 citation statements)

References 33 publications

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“…On the other hand, osteogenesis and adipogenesis are regarded to be closely correlated with the capacity of the progenitor cells during bone regeneration, and many reagents have been demonstrated to have opposite impacts on osteogenesis and adipogenesis. [44][45][46][47][48] In this regard, we and others have recently reported that fullerol could inhibit the differentiation of marrow stromal cells and OP9 preadipocytes into adipocytes due to its scavenging activity against intracellular ROS. 26,49,50 Taken together, these findings highlighted fullerol as a novel pharmaceutical candidate for the purpose of producing augmented bone regeneration.…”

mentioning

confidence: 89%

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

Yang¹,

Li²,

Wan³

et al. 2014

IJN

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Antioxidants were implicated as potential reagents to enhance osteogenesis, and nano-fullerenes have been demonstrated to have a great antioxidative capacity by both in vitro and in vivo experiments. In this study, we assessed the impact of a polyhydroxylated fullerene, fullerol, on the osteogenic differentiation of human adipose-derived stem cells (ADSCs). Fullerol was not toxic against human ADSCs at concentrations up to 10 μM. At a concentration of 1 μM, fullerol reduced cellular reactive oxygen species after a 5-day incubation either in the presence or in the absence of osteogenic media. Pretreatment of fullerol for 7 days increased the osteogenic potential of human ADSCs. Furthermore, when incubated together with osteogenic medium, fullerol promoted osteogenic differentiation in a dose-dependent manner. Finally, fullerol proved to promote expression of FoxO1, a major functional isoform of forkhead box O transcription factors that defend against reactive oxygen species in bone. Although further clarification of related mechanisms is required, the findings may help further development of a novel approach for bone repair, using combined treatment of nano-fullerol with ADSCs.

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confidence: 89%

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

Yang¹,

Li²,

Wan³

et al. 2014

IJN

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“…Transforming growth factor β1 (TGFβ1) is a pleiotropic cytokine, that is ubiquitously expressed in most tissues with a wide range of biological functions including senescence [1], cell proliferation [2], apoptosis [3], tumor suppression [2], differentiation [4], migration [5], immunity [6], osteogenesis [7], adipogenesis [8], and wound healing [9]. …”

Section: Introductionmentioning

confidence: 99%

The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure

Matsuki¹,

Hathaway²,

Lawrence³

et al. 2015

CHYR

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Although human association studies suggest a link between polymorphisms in the gene encoding transforming growth factor (TGF) β1 and differing blood pressure levels, a causative mechanism for this correlation remains elusive. Recently we have generated a series of mice with graded expression of TGFβ1, ranging from approximately 10% to 300% compared to normal. We have found that blood pressure and plasma volume are negatively regulated by TGFβ1. Of note, the 10% hypomorph exhibits primary aldosteronism and markedly impaired urinary excretion of water and electrolytes. We here review previous literature highlighting the importance of TGFβ signaling as a natriuretic system, which we postulate is a causative mechanism explaining how polymorphisms in TGFβ1 could influence blood pressure levels.

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“…Transforming growth factor beta1 (TGFbeta1), the prototypic member of the TGFbeta superfamily, is a potent pleiotropic cytokine with effects on a broad range of biological processes including apoptosis[3], cell proliferation[4], tumor suppression[4], senescence[5], differentiation[6], migration[7], immunity[8], osteogenesis[9], adipogenesis[10], and wound healing[11]. In addition, a growing number of convincing evidence indicates that both angiotensin II and aldosterone activate TGFbeta signaling, which mediates many of the complications of RAAS-related hypertension including progressive renal dysfunction[2] and cardiac hypertrophy[12].…”

Section: Introductionmentioning

confidence: 99%

Transforming growth factor beta1 and aldosterone

Matsuki

Hathaway

Chang

et al. 2015

Current Opinion in Nephrology and Hypertension

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Purpose of review It is well established that blocking renin-angiotensin II-aldosterone system (RAAS) is effective for the treatment of cardiovascular and renal complications in hypertension and diabetes mellitus. Although the induction of transforming growth factor beta1 (TGFbeta1) by components of RAAS mediates the hypertrophic and fibrogenic changes in cardiovascular-renal complications, it is still controversial as to whether TGFbeta1 can be a target to prevent such complications. Here we review recent findings on the role of TGFbeta1 in fluid homeostasis, focusing on the relationship with aldosterone. Recent findings TGFbeta1 suppresses adrenal production of aldosterone and renal tubular sodium reabsorption. We have generated mice with TGFbeta1 mRNA expression graded in five steps from 10% to 300% normal, and found that blood pressure and plasma volume are negatively regulated by TGFbeta1. Notably, the 10 % hypomorph exhibits primary aldosteronism and sodium and water retention due to markedly impaired urinary excretion of water and electrolytes. Summary These results identify TGFbeta signaling as an important counterregulatory system against aldosterone. Understanding the molecular mechanisms for the suppressive effects of TGFbeta1 on adrenocortical and renal function may further our understanding of primary aldosteronism as well as assist in the development of novel therapeutic strategies for hypertension.

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Reversine increases the plasticity of lineage-committed preadipocytes to osteogenesis by inhibiting adipogenesis through induction of TGF-β pathway in vitro

Cited by 22 publications

References 33 publications

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure

Transforming growth factor beta1 and aldosterone

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Reversine increases the plasticity of lineage-committed preadipocytes to osteogenesis by inhibiting adipogenesis through induction of TGF-β pathway in vitro

Cited by 22 publications

References 33 publications

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

The Role of Transforming Growth Factor &#946;1 in the Regulation of Blood Pressure

Transforming growth factor beta1 and aldosterone

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The Role of Transforming Growth Factor β1 in the Regulation of Blood Pressure