Reversible Insensitivity to Androgens in Men With Untreated Gluten Enteropathy

Green, J.R.B.; Edwards, C. R. W.; Goble, Hilary; Dawson, A. M.

doi:10.1016/s0140-6736(77)91825-6

Cited by 48 publications

(19 citation statements)

References 7 publications

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“…In coeliac sprue there are deficient levels of plasma 5a-reductase, resulting in reduced conversion of testosterone to dihydrotestosterone. Cerebral 5a-reductase levels may also be low and this could explain the high levels of luteinizing hormone through a failure of the negative feedback effect of testosterone [18,24,25], It is likely that the enzyme 5a-reductase is to some extent produced by gut mucosa since supplements of androgenic hormones or glu ten restriction both result in normalization of the mucosa and reversal of these hormonal changes [18].…”

Section: Hormonal Changesmentioning

confidence: 99%

Infertility, Obstetric and Gynaecological Problems in Coeliac Sprue

Sher

Venkataraman

Probert

et al. 1994

Dig Dis

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There is now substantial evidence that coeliac sprue is associated with infertility both in men and women. In women it can also lead to delayed menarche, amenorrhoea, early menopause, recurrent abortions, and a reduced pregnancy rate. In men it can cause hypogonadism, immature secondary sex characteristics and reduce semen quality. The real mechanism by which coeliac sprue produces these changes is unclear, but factors such as malnutrition, iron, folate and zinc deficiencies have all been implicated. In addition in men gonadal dysfunction is believed to be due to reduced conversion of testosterone to dihydrotestosterone caused by low levels of 5α-reductase in coeliac sprue. This leads to derangement of the hypothalamicpituitary axis. Hyperprolactinaemia is seen in 25% of coeliac patients, which causes impotence and loss of libido. Gluten withdrawal and correction of deficient dietary elements can lead to a return of fertility both in men and women.

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Section: Hormonal Changesmentioning

confidence: 99%

Infertility, Obstetric and Gynaecological Problems in Coeliac Sprue

Sher

Venkataraman

Probert

et al. 1994

Dig Dis

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“…Earlier research suggests that CD is associated with androgen resistance (8,9) (lower levels of dihyrotestosterone and elevated LH [10]) and lower levels of dehydroepiandrosterone sulphate (11). In their study, Farthing et al describe two men with CD who had markedly reduced sperm motility (8).…”

mentioning

confidence: 99%

Celiac disease is not a risk factor for infertility in men

Zugna

Richiardi

Akre

et al. 2011

Fertility and Sterility

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“…In contrast 5 a-dihydrotestosterone concentrations are lower than normal. These changes revert to normal with a gluten free diet (Green et al, 1977) suggesting reversible androgen resistance. This is not seen in Crohn's disease for example, so is not just a manifestation of gastrointestinal illness and malnutrition.…”

Section: Gastrointestinal Diseasementioning

confidence: 92%