Celiac disease is not a risk factor for infertility in men

Zugna, Daniela; Richiardi, Lorenzo; Akre, Olof; Stephansson, Olof; Ludvigsson, Jonas F.

doi:10.1016/j.fertnstert.2011.01.132

Cited by 19 publications

(11 citation statements)

References 37 publications

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“…7 It is estimated that 10% of stillbirths are due to maternal factors including hypertension, diabetes, smoking, and obesity. 22, 23 Indeed our findings demonstrated that history of stillbirth and miscarriages 24 were associated with incident CHD, independent of established risk factors, other reproductive/pregnancy risk factors and SES.…”

Section: Discussionsupporting

confidence: 51%

Reproductive Risk Factors and Coronary Heart Disease in the Women’s Health Initiative Observational Study

et al. 2016

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Background Reproductive factors provide an early window into a woman’s coronary heart disease (CHD) risk, however their contribution to CHD risk stratification is uncertain. Methods and Results In the Women’s Health Initiative Observational Study, we constructed Cox proportional hazards models for CHD including age, pregnancy status, number of live births, age at menarche, menstrual irregularity, age at first birth, stillbirths, miscarriages, infertility ≥ 1 year, infertility cause, and breastfeeding. We next added each candidate reproductive factor to an established CHD risk factor model. A final model was then constructed with significant reproductive factors added to established CHD risk factors. Improvement in C-statistic, net reclassification index (or NRI with risk categories of <5%, 5–<10%, and ≥10% 10-year risk of CHD) and integrated discriminatory index (IDI) were assessed. Among 72,982 women [n=4607 CHD events, median follow-up=12.0 (IQR=8.3–13.7) years, mean (SD) age 63.2 (7.2) years], an age-adjusted reproductive risk factor model had a C-statistic of 0.675 for CHD. In a model adjusted for established CHD risk factors, younger age at first birth, number of still births, number of miscarriages and lack of breastfeeding were positively associated with CHD. Reproductive factors modestly improved model discrimination (C-statistic increased from 0.726 to 0.730; IDI=0.0013, p-value < 0.0001). Net reclassification for women with events was not improved (NRI events=0.007, p-value=0.18); and for women without events was marginally improved (NRI non-events=0.002, p-value=0.04) Conclusions Key reproductive factors are associated with CHD independently of established CHD risk factors, very modestly improve model discrimination and do not materially improve net reclassification.

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Section: Discussionsupporting

confidence: 51%

Reproductive Risk Factors and Coronary Heart Disease in the Women’s Health Initiative Observational Study

et al. 2016

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“…Subfertility in CD has been much debated. Three large papers have shown a normal overall fertility in women with CD 113–115 (and one paper in men with CD 116 ). In the largest of these studies, Zugna et al.…”

Section: Resultsmentioning

confidence: 99%

Support for patients with celiac disease: A literature review

et al. 2015

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“…Before treatment with a strict gluten-free diet, men may experience impaired pituitary regulation of gonadal endocrine function (186). The inflammatory response to gluten consumption in individuals with gluten intolerance creates an adverse environment for reproductive tissue maintenance and function (187). Available evidence does not show an increased risk of subfertility in men with CD, although auto-antibodies can be found in seminal fluid of men with unrecognized disease (187,188).…”

Section: Glutenmentioning

confidence: 99%

Nutrition, genetic variation and male fertility

Vanderhout¹,

Panah²,

García‐Bailo³

et al. 2021

Transl Androl Urol

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Infertility affects nearly 50 million couples worldwide, with 40−50% of cases having a male factor component. It is well established that nutritional status impacts reproductive development, health and function, although the exact mechanisms have not been fully elucidated. Genetic variation that affects nutrient metabolism may impact fertility through nutrigenetic mechanisms. This review summarizes current knowledge on the role of several dietary components (vitamins A, B 12 , C, D, E, folate, betaine, choline, calcium, iron, caffeine, fiber, sugar, dietary fat, and gluten) in male reproductive health. Evidence of genenutrient interactions and their potential effect on fertility is also examined. Understanding the relationship between genetic variation, nutrition and male fertility is key to developing personalized, DNA-based dietary recommendations to enhance the fertility of men who have difficulty conceiving.

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Celiac disease is not a risk factor for infertility in men

Cited by 19 publications

References 37 publications

Reproductive Risk Factors and Coronary Heart Disease in the Women’s Health Initiative Observational Study

Reproductive Risk Factors and Coronary Heart Disease in the Women’s Health Initiative Observational Study

Support for patients with celiac disease: A literature review

Nutrition, genetic variation and male fertility

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