Reversibility of lung function abnormalities in children with perennial asthma

Kraemer, Richard; Meister, Beat; Schaad, Urs B.; Rossi, E

doi:10.1016/s0022-3476(83)80646-5

Cited by 43 publications

(22 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The adults were all nonsmoking healthy subjects, with normal lung function and without history of cardiopulmonary or other diseases. The asthmatic children had a history of atopic disease and reversible bronchial obstruction and/or bronchial hyperreactivity (carbachol challenge test) [7]. Before test measurements were made, each subject received careful instructions on how to use the IFW and was allowed to use it up to 5 times in order to feel comfortable with the device.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

An Isoflow-Volume Technique for Assessing Airway Dynamics in Children and Adults

Schibler

Frey²,

Kraemer³

2001

Respiration

View full text Add to dashboard Cite

Background: We propose a new approach to the measurement of small airway function as an alternative to recordings of maximal expiratory flow-volume (MEFV) curves. Objectives: A newly developed technique to record isoflow-volume (IFV) curves to be tested against maximal respiratory flow curves. Methods: An isoflow whistle (IFW; Iflopen^®) measures the length of a constant expiration after full inspiration. The note of the whistle enables a subject to generate an even expiration, and the isoflow maintenance times at 1 l·s^–1 (IFMT₁) and 2 l·s^–1 (IFMT₂) are recorded. The accuracy and reproducibility of the IFV technique were evaluated in 17 healthy adults (age 17–55 years) and in 14 asthmatic children (age 6–14 years). Comparisons with standard lung function parameters, such as forced expiratory volume in 1 s (FEV₁), maximal expiratory flow at 50% (MEF₅₀) and 25% (MEF₂₅) vital capacity and peak expiratory flow (PEF), obtained with a Wright^® Peakflow Meter were undertaken in 102 healthy (aged 8–14 years) and 101 asthmatic children (aged 6–17 years). A bronchial challenge test was performed in 13 asthmatic children. Results: The expired volume measured by the IFW showed an acceptable agreement with that of a pneumotachograph (mean error of 4.32% for IFMT₁ and 5.93% for IFMT₂). In healthy and in asthmatic children, the correlations between FEV₁ and IFMT₁ or IFMT₂ (r = 0.92 and 0.94, respectively) were found to be greater than that between FEV₁ and PEF (r = 0.68). During bronchial challenge tests in 13 asthmatic children, the FEV₁ decreased to 69% of baseline and IFMT₁ to 58% of baseline. Conclusions: The IFV technique accurately measured airway obstruction and closely followed changes in standard parameters of the MEFV curve.

show abstract

Section: Methodsmentioning

confidence: 99%

“…Measurements were repeated five times to assess the intrasubject variability and the reproducibility of the measurements. All children had carbachol challenge test using an interrupter technique (Bronchoscreen ® from Jaeger) [10]. …”

Section: Methodsmentioning

confidence: 99%

An Isoflow-Volume Technique for Assessing Airway Dynamics in Children and Adults

Schibler

Frey²,

Kraemer³

2001

Respiration

View full text Add to dashboard Cite

show abstract

“…All patients were known to have asthma for more than 1 year with episodic dyspnea, positive skin tests, positive RAST results, well documented varying reversible bronchoconstriction (positive response to P-2-mimetics), bronchial hyperreactivity (histamine challenge test), and positive bronchial challenge test to one or more allergens. All patients were familiar with the lung function technique applied and were evaluated strictly during the symptom-free interval (9,23). Nevertheless, they had mild to severe occult lung function abnormalities.…”

Section: Methodsmentioning

confidence: 99%

“…TGV, thoracic gas volume TLC, total lung capacity VC, vital capacity VL, lung volume One of the epidemiological aspects of childhood asthma is the question of the reversibility of functional abnormalities (23) and in particular how this factor relates to the potential to develop chronic obstructive lung disease. In this paper, we describe some functional features which may serve as indicators of later lung damage.…”

mentioning

confidence: 99%

Lung Distensibility and Airway Function in Asthmatic Children

Kraemer¹,

Geubelle²

1984

Pediatr Res

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Lung distensibility and airway mechanics were evaluated in 24 asthmatic children and adolescents, ages between 7 and 21 years, by quasi-static pressurevolume curves and by the static recoil-lung conductance relationship. The measurements were obtained by the stepwise inflation technique and the pressure-volume curves were analyzed by a new sigmoid exponential curve-fitting model of the form: VL = Vm + [VM/(l + be-K.P*~)], where

show abstract

“…The technique has been described previously [15]. Lung function data were expressed as a percentage of predicted values [16].…”

Section: Baseline Lung Function Testsmentioning

confidence: 99%

Oscillatory pressure transients after flow interruption during bronchial challenge test in children

Frey¹,

Kraemer²

1997

Eur Respir J

View full text Add to dashboard Cite

The measurement of the conventional interrupter resistance (Rint) is dependent on pressure equilibration between alveolar and airway opening pressure, which is often not achieved in the presence of severe airways obstruction or in small children. The damping properties (d) of postocclusional oscillatory pressure transients after rapid flow interruption can be assessed independent of complete pressure equilibration, and we have previously shown them to be correlated to resistive properties of the respiratory system. We wanted to determine whether these transients were an expression of acoustic properties of the air in the airways, or whether they were caused by an interaction of gas and lung tissue, and whether d was more sensitive than Rint to changes in airway mechanics.Bronchial challenge tests were carried out with cumulative doses of inhaled carbachol in 10 healthy children (aged 7-14 yrs) and 50 asthmatic children (aged 5-15 yrs). The airflow interruptions were performed with a combined nebulizer-shutter head, allowing resistance measurements with each breath.The frequency, and the damping factor of the postocclusional pressure transients changed significantly during carbachol challenge in both groups of children. The provocation dose (PD) at which the damping factor (d) of the oscillatory pressure transients increased more than 2 SD above the baseline mean ("variancebased", PDvb) was lower than the PDvb of the end-interruption resistance (Rint,EI). These changes in frequency and damping factor were reversible after inhaling salbutamol.These findings suggest that the damping properties of the postocclusional pressure transients after flow interruption can be used as a sensitive parameter to assess changes in airway mechanics during bronchial challenge test in children in whom pressure equilibration is frequently not achieved during airflow interruption due to airways obstruction. Eur Respir J., 1997; 10: 75- The interrupter technique [1-6] has been shown to be a simple noninvasive method of measuring changes in airway mechanics in children [7] or patients with limited co-operation. However, the reliability of the measurements of the interrupter resistance (Rint) has been questioned in severe airway obstruction or in small children with a generally higher airway resistance, since the measurement of Rint depends on complete pressure equilibration between alveoli and airway opening. Different techniques to analyse the airway opening pressure curve after flow interrupter have been proposed. A comparison of these analytical techniques by PHAGOO et al. [8] showed that the end-interrupter resistance (Rint,EI) reflects changes in lung mechanics most sensitively.This Rint,EI is calculated from the airway opening pressure (time function) signal Pao(t ') as follows: based on the assumption that, during a brief period (100 ms) of airflow interruption, rapid equilibration between alveolar pressure (PA) and airway opening pressure (Pao) occurs, the Rint,EI is obtained by dividing the change in pressure 100 ms...

show abstract

Reversibility of lung function abnormalities in children with perennial asthma

Cited by 43 publications

References 20 publications

An Isoflow-Volume Technique for Assessing Airway Dynamics in Children and Adults

An Isoflow-Volume Technique for Assessing Airway Dynamics in Children and Adults

Lung Distensibility and Airway Function in Asthmatic Children

Oscillatory pressure transients after flow interruption during bronchial challenge test in children

Contact Info

Product

Resources

About