Lung Distensibility and Airway Function in Asthmatic Children

Kraemer, Richard; Geubelle, F

doi:10.1203/00006450-198411000-00020

Cited by 10 publications

(1 citation statement)

References 30 publications

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“…absent after bronchodilator administration (often performed in children). 8 As previously done by Kraemer et al, 3,9 we hypothesized that different functional phenotypes can be evidenced in asthmatic children, such as an involvement of both proximal (reflected by airflow limitation) and distal (reflected by hyperinflation) airways. The specific aim of the study was to test the hypothesis that the former can not predict the latter.…”

Section: Introductionmentioning

confidence: 84%

Abnormalities of plethysmographic lung volumes in asthmatic children

Mahut

Bokov

Delclaux

2010

Respiratory Medicine

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Section: Introductionmentioning

confidence: 84%

Abnormalities of plethysmographic lung volumes in asthmatic children

Mahut

Bokov

Delclaux

2010

Respiratory Medicine

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Lung recoil and the determination of airflow limitation in cystic fibrosis and asthma

Zapletal

Desmond

Demizio

et al. 1993

Pediatric Pulmonology

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A reduction of lung recoil pressure could aggravate any airflow limitation that might be present in patients with cystic fibrosis (CF) or asthma. In a group of 22 children and young adults (8 with cystic fibrosis, 8 with asymptomatic asthma, and 6 healthy controls) aged 8-24 years, lung recoil pressure (Pst) at 100%, 90%, and 60% of TLC and static lung compliance (Cst) were measured using an esophageal balloon. The indices of airflow limitation, including maximal expiratory flow at 25% VC (Vmax25), forced expiratory volume in 1 second (FEV1), and specific airway conductance (sGaw), were also measured. In all patients, Vmax25 was reduced, the airway obstruction being more pronounced in patients with CF. Pst was reduced in CF and asthma, again more in the patients with CF. Cst was normal in both groups because the pressure volume curve was shifted up and to the left. There were significant correlations between Pst at 60%, 90%, and 100% of TLC and both Vmax25 and FEV1 (P < 0.01). sGaw correlated with Pst90 and Pst60 (r = 0.47 and 0.53, respectively; P < 0.05 for both). No correlation was found between Cst and Pst at any lung volume. No correlations were observed between Cst and Vmax25, FEV1, or sGaw. These results suggest that loss of elastic lung recoil pressure is a factor in airflow limitation of children and young adults with CF or asthma.

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Interrelationship between postocclusional oscillatory pressure transients and standard lung function in healthy and asthmatic children

Frey¹,

Kraemer²

1995

Pediatric Pulmonology

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We studied the correlation between characteristics of the postocclusional oscillatory airway opening pressure transients after flow interruption and body height, the degree of pulmonary hyperinflation [measured by thoracic gas volume (TGV)], and the degree of airway obstruction [measured by airway resistance (Raw)] and maximal expiratory flow at 50% vital capacity (MEF50) in 10 healthy and 50 asthmatic children age 7-16 years. Focusing on the damped oscillatory change in pressure, the first derivative of the shutter curve was analyzed, featuring a natural frequency fO and damping factor d in the time domain, and frequency FFS and power AFS in the frequency domain. A maximal frequency was found at approximately 80 Hz without a two peak distribution as described in dogs. Multiple linear forward step analysis revealed that omega O (the undamped, natural frequency) and AFS were related to body height (P < 0.001). The damping factor d (independent of body height) was related to TGV and MEF50 (P < 0.001), and FFS to Raw (P < 0.001). The analysis of the postocclusional pressure transients after airflow interruption provides information on the resistive, elastic and inertive properties of the thoraco-pulmonary system. The measurements obtained are influenced by the end-expiratory resting level (or the degree of pulmonary hyperinflation) and the degree of airway obstruction.

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Lung Distensibility and Airway Function in Asthmatic Children

Cited by 10 publications

References 30 publications

Abnormalities of plethysmographic lung volumes in asthmatic children

Abnormalities of plethysmographic lung volumes in asthmatic children

Lung recoil and the determination of airflow limitation in cystic fibrosis and asthma

Interrelationship between postocclusional oscillatory pressure transients and standard lung function in healthy and asthmatic children

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