Reversibility of cachexia after bilateral lung transplantation

Habedank, Dirk; Ewert, Ralf; Hetzer, Roland; Anker, Stefan D.

doi:10.1016/j.ijcard.2007.11.077

Cited by 19 publications

(12 citation statements)

References 23 publications

(38 reference statements)

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“…In another study of 341 lung transplant recipients, patients had no change in weight at 6 months post‐transplantation, but gained a mean of 3.3 kg at 12 months post‐transplantation . Both of these studies found that a lower pre‐transplantation BMI was associated with greater weight gain, a finding confirmed by Habedank et al . Cachectic patients (defined as BMI ≤21 kg/m 2 ) gained weight at the first follow‐up 3 months post‐transplantation, and weight continued to increase through 24 months of follow‐up.…”

Section: Discussionmentioning

confidence: 70%

Determinants of pre‐transplantation pectoralis muscle area (PMA) and post‐transplantation change in PMA in lung transplant recipients

Hoang

Kao

et al. 2017

Clinical Transplantation

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Section: Discussionmentioning

confidence: 70%

Determinants of pre‐transplantation pectoralis muscle area (PMA) and post‐transplantation change in PMA in lung transplant recipients

Hoang

Kao

et al. 2017

Clinical Transplantation

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“…Patients with PH who experience loss of body weight have increased mortality rate after lung transplantation [31]. Loss of muscle mass is an important component of loss of body weight in chronic diseases [32]–[34].…”

Section: Discussionmentioning

confidence: 99%

Diaphragm Atrophy and Contractile Dysfunction in a Murine Model of Pulmonary Hypertension

et al. 2013

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Pulmonary hypertension (PH) causes loss of body weight and inspiratory (diaphragm) muscle dysfunction. A model of PH induced by drug (monocrotaline, MCT) has been extensively used in mice to examine the etiology of PH. However, it is unclear if PH induced by MCT in mice reproduces the loss of body weight and diaphragm muscle dysfunction seen in patients. This is a pre-requisite for widespread use of mice to examine mechanisms of cachexia and diaphragm abnormalities in PH. Thus, we measured body and soleus muscle weight, food intake, and diaphragm contractile properties in mice after 6–8 weeks of saline (control) or MCT (600 mg/kg) injections. Body weight progressively decreased in PH mice, while food intake was similar in both groups. PH decreased (P<0.05) diaphragm maximal isometric specific force, maximal shortening velocity, and peak power. Protein carbonyls in whole-diaphragm lysates and the abundance of select myofibrillar proteins were unchanged by PH. Our findings show diaphragm isometric and isotonic contractile abnormalities in a murine model of PH induced by MCT. Overall, the murine model of PH elicited by MCT mimics loss of body weight and diaphragm muscle weakness reported in PH patients.

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“…At two months, the heart recipients had a significant weight loss that could be attributed to the loss of fluid. However, it has been shown that early weight loss is related to poor outcome (37, 38). At two months, the energy intake was positively associated with BMI, which indicates a potential to improve dietary intake and suggest that the profit of dietary follow‐up earlier than two months could be worth investigating.…”

Section: Discussionmentioning

confidence: 99%

Disturbed energy metabolism after lung and heart transplantation

Førli¹,

Bollerslev²,

Simonsen³

et al. 2010

Clinical Transplantation

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Overweight, in combination with other cardiovascular risk factors, reduces survival after transplantation. The aim of this prospective study was to observe leptin, adiponectin, and energy intake as predictors of body mass index (BMI) and body composition and as risk factors associated with metabolic syndrome after lung and heart transplantation. After pre-operative baseline investigations, 35 lung and 59 heart recipients were followed and re-investigated two, six, and 12 months after transplantation. Linear regressions were performed to predict BMI and body composition. The lung recipients had a substantial weight gain after transplantation. Leptin increased, especially in the lung recipients and positively predicted BMI. Energy intake predicted BMI before and at two months after transplantation, but not after 12 months. Percentage trunk fat increased and lean mass decreased. Before transplantation, the dominant determinant of lean mass was adiponectin (positively associated), while after it was leptin (negatively associated), controlled for possible confounding variables (including prednisolone). Metabolic syndrome 12 months after transplantation was associated with higher leptin, greater weight gain without increased energy intake. After transplantation, a disturbed energy metabolism is indicated, where adiponectin and especially leptin are involved and a disadvantageous body composition is favored with increased body fat and decreased lean mass.

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Reversibility of cachexia after bilateral lung transplantation

Cited by 19 publications

References 23 publications

Determinants of pre‐transplantation pectoralis muscle area (PMA) and post‐transplantation change in PMA in lung transplant recipients

Determinants of pre‐transplantation pectoralis muscle area (PMA) and post‐transplantation change in PMA in lung transplant recipients

Diaphragm Atrophy and Contractile Dysfunction in a Murine Model of Pulmonary Hypertension

Disturbed energy metabolism after lung and heart transplantation

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