Determinants of pre‐transplantation pectoralis muscle area (PMA) and post‐transplantation change in PMA in lung transplant recipients

Abstract

Underlying diagnosis was a significant predictor of both pre-transplantation PMI and change in PMI post-transplantation. Further studies of PMI are needed to determine its clinical utility in predicting outcomes following lung transplantation.

Quantity and quality of antigravity muscles in patients undergoing living-donor lobar lung transplantation: 1-year longitudinal analysis using chest computed tomography images

“…Although several reports have shown the time course of muscle mass before and after LTx [6,15], the present report is the first to show the time course of both muscle quality and muscle quantity and the significant impacts on exercise capacity after LDLLT. Our additional important findings are the temporary decreases in and later recovery of antigravity muscle mass after LDLLT.…”

“…Although preoperative and postoperative therapeutic approaches are available to address early morbidities and various other physical issues [13,14], it is still not well known how muscle dysfunction changes over time after LTx. Skeletal muscle mass loss may not recover 1 year after LTx, the degree of recovery varies widely [15], and delayed recovery of skeletal muscles may lead to limited exercise performance [2,3]. Both muscle quantity and quality may contribute to physiological performance in LTx candidates, and consequently, pre-existing conditions may affect both the postoperative course and physical performance.…”

Preoperative Pectoralis Muscle Quantity and Attenuation by Computed Tomography Are Novel and Powerful Predictors of Mortality After Left Ventricular Assist Device Implantation

“…Because CT scans of the chest are often performed as part of LVAD surgical planning, we analyzed the pectoralis muscle as a potential predictor of outcomes based on previous studies in nonheart failure populations. [8][9][10] In this study, we report that unilateral pectoralis muscle attenuation 11 and quantity indexed to height (PHU m and PMI, respectively) were powerful predictors of mortality after LVAD and outperformed other traditional clinical variables tested in this data set.…”

Clinical outcomes associated with computed tomography‐based body composition measures in lung transplantation: a systematic review

“…Other image processing softwares were also employed, including one study that assessed psoas muscle composition using three‐dimensional (3D) imaging with a Synapse visualization software [29]. Pectoralis muscle for chest CT ( n = 3) [18–20], the psoas muscle from abdominal CT ( n = 6) [14,15,23,29–31], and paraspinal muscles from chest or abdominal CT ( n = 5) [19–22,31] were the most common muscles included among the selected studies, in comparison to the intercostals ( n = 3) [19,20,22], serratus anterior ( n = 1) [19] and latissimus dorsi muscles ( n = 2) [19,22], as shown in Table 1. The majority of studies utilized one axial slice ( n = 7) [18,20–23,30,31] with several studies taking the average of two to three slices [14,15,19].…”

“…The literature on CT‐based body composition in lung transplantation shows that various landmarks from thoracic and lumbar CT scans have been used to evaluate body composition. Investigators have evaluated muscle CSA of single muscles, such as the pectorals [16,18] or multiple muscles of the chest [19,20], whereas only a few studies have examined adipose depots from thoracic CT [21,22]. Also, several studies have evaluated the relationship of pretransplant muscle CSA from CT scans and their relationship with post‐transplant outcomes, such as days of mechanical ventilation (MV), hospital LOS, and mortality [19,20,23].…”