Reversed-phase ion-pair partition chromatography of phenylacetic, mandelic and pyridinecarboxylic acid derivatives

Wahlund, Karl-Gustav; Lund, Ulla

doi:10.1016/s0021-9673(00)82249-9

Cited by 54 publications

(10 citation statements)

References 8 publications

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“…This substitution, especially in studies involving tetrabutylammonium cation, desensitizes the mobile and stationary phases to fluctuations in ambient temperature, which could have a large effect on pentanol saturation levels (5,6). In addition, routine column cleanup procedures can be performed without a prolonged reequilibration step.…”

Section: Results a N D Discussionmentioning

confidence: 99%

“…In addition, routine column cleanup procedures can be performed without a prolonged reequilibration step. The stripping of pentanol from a reversed-phase stationary support was documented (6).…”

Section: Results a N D Discussionmentioning

confidence: 99%

“…The noncharged solutes such as meprobamate, carisoprodol, and methocarbamol had a wide range of retention times in methanolwater systems (k' = 0. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Increasing the polarity of the mobile phase (Solvents A -C) predictably increased the k' value for any selected neutral solute.…”

Section: Results a N D Discussionmentioning

confidence: 99%

“…Therefore, ion-pair formation with tetrabutylammonium cation was investigated, especially with mixtures containing aspirin. The use of tetrabutylammonium cation as a suitable counterion in HPLC was investigated previously (4)(5)(6). Ion-pair formation also was utilized (7-9) as a tool for effecting chromatographic analysis of selected organic ions.…”

Section: Referencesmentioning

confidence: 99%

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Liquid Chromatography in Pharmaceutical Analysis XI: Determination of Muscle Relaxant-Analgesic Mixtures Using Reversed-Phase and Ion-Pair Techniques

Stewart

Honigberg

Coldren

1979

Journal of Pharmaceutical Sciences

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Section: Results a N D Discussionmentioning

confidence: 99%

Section: Results a N D Discussionmentioning

confidence: 99%

Section: Results a N D Discussionmentioning

confidence: 99%

Section: Referencesmentioning

confidence: 99%

See 2 more Smart Citations

Liquid Chromatography in Pharmaceutical Analysis XI: Determination of Muscle Relaxant-Analgesic Mixtures Using Reversed-Phase and Ion-Pair Techniques

Stewart

Honigberg

Coldren

1979

Journal of Pharmaceutical Sciences

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“…Much of the theory and application of ion-pair techniques has been attributed to Schill and coworkers in Sweden (1)(2)(3)(4). One distinct advantage of using ion-pairing in pharmaceutical analysis is that the low detection response of some drugs can be Salicylic Acid greatly improved using counter-ions of high molar absorptivity or fluorescence intensity (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Flow Injection Analysis of Carboxylic Acid Drugs Using Cationic Dyes and On-Line Ion-Pair Extraction

Stewart¹,

Lang²,

Honigberg³

1988

Journal of Liquid Chromatography

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Journal of Liquid ChromatographyPublication details, including instructions for authors and subscription information:ABSTRACT A flow injection system containing an on-line ion-pair extractor has been designed for the analysis of carboxylic acid drugs using either spectrophotometric detection with gentian violet as counterion or fluorescence detection with acridine orange. Salicylic acid, valproic acid, and ibuprofen were selected as model drugs. phosphate buffer-absolute methanol was pumped through the system at 1 ml/min. A chloroform solution of the cationic dye was pumped into the mobile phase at 1.25 ml/min and the chloroform layer containing the dye-drug ion-pair separated prior to detection. Peak height and absorbance were linear €or salicylic acid, valproic acid, and ibuprofen in the 0.5-10, 5-50, and 1-10 pg/ml ranges, respectively. Peak height and fluorescence were linear for salicylic acid, valproic acid, and ibuprofen in the 0.13-5, 2.5-50, and 0.5-20 ug/ml ranges, respectively. Accuracy and precision for the spectrophotometric assays were in the 2-6% and 3.3-6.6% ranges, respectively, and in the 0.3-4% and 1.3-5.4% ranges, respectively, for the fluorescence assays. Peak height and absorbance were also shown to be linear in the A mobile phase of 9O:lO aqueous pH 7 3353 Copyright 0 1988 by Marcel Dekker, Inc. Downloaded by [University of Calgary] at 02:40 06 February 2015 3354 STEWART, LANG, AND HONIGBERG16-500 pg/ml range for prostaglandin PGF precision of 1-3% and 5 4 % . respectively?afor spiked samples.Commercial dosage forms containing valproic acid and ibuprofen were assayed by the spectrophotometric assay and found to be within acceptable USP limits. Spiked ibuprofen samples at the 5 and 10 pg/ml level were assayed using an octadecylsilane column inserted into the flow injection system. One to two percent accuracy and 2.5-5% precision were obtained for the drug using the FIA-column system. with accuracy and

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HPLC Sample Injection and Column Switching

Harvey¹,

Stearns²

1984

Liquid Chromatography in Environmental Analysis

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Reversed-phase ion-pair partition chromatography of phenylacetic, mandelic and pyridinecarboxylic acid derivatives

Cited by 54 publications

References 8 publications

Liquid Chromatography in Pharmaceutical Analysis XI: Determination of Muscle Relaxant-Analgesic Mixtures Using Reversed-Phase and Ion-Pair Techniques

Liquid Chromatography in Pharmaceutical Analysis XI: Determination of Muscle Relaxant-Analgesic Mixtures Using Reversed-Phase and Ion-Pair Techniques

Flow Injection Analysis of Carboxylic Acid Drugs Using Cationic Dyes and On-Line Ion-Pair Extraction

HPLC Sample Injection and Column Switching

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