Revelations from the Nematode<i>Caenorhabditis elegans</i>on the Complex Interplay of Metal Toxicological Mechanisms

Martinez-Finley, Ebany J.; Aschner, Michael

doi:10.1155/2011/895236

Cited by 46 publications

(35 citation statements)

References 78 publications

(89 reference statements)

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“…In a stressful environment, however, the expression of genes governing quantitative traits can be masked by the action of genes involved in detoxification (Hoffmann & Parsons, 1991). Indeed, C. elegans’ tolerance to several heavy metals, including uranium, is related to one or a few major genes (Aschner & Martinez‐Finley, 2011). These genes with major effects may mask the expression of genes for quantitative traits, such as life history traits.…”

Section: Discussionmentioning

confidence: 99%

Adaptation costs to constant and alternating polluted environments

Dutilleul

Réale

Goussen

et al. 2017

Evolutionary Applications

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Some populations quickly adapt to strong and novel selection pressures caused by anthropogenic stressors. However, this short‐term evolutionary response to novel and harsh environmental conditions may lead to adaptation costs, and evaluating these costs is important if we want to understand the evolution of resistance to anthropogenic stressors. In this experimental evolution study, we exposed Caenorhabditis elegans populations to uranium (U populations), salt (NaCl populations) and alternating uranium/salt treatments (U/NaCl populations) and to a control environment (C populations), over 22 generations. In parallel, we ran common‐garden and reciprocal‐transplant experiments to assess the adaptive costs for populations that have evolved in the different environmental conditions. Our results showed rapid evolutionary changes in life history characteristics of populations exposed to the different pollution regimes. Furthermore, adaptive costs depended on the type of pollutant: pollution‐adapted populations had lower fitness than C populations, when the populations were returned to their original environment. Fitness in uranium environments was lower for NaCl populations than for U populations. In contrast, fitness in salt environments was similar between U and NaCl populations. Moreover, fitness of U/NaCl populations showed similar or higher fitness in both the uranium and the salt environments compared to populations adapted to constant uranium or salt environments. Our results show that adaptive evolution to a particular stressor can lead to either adaptive costs or benefits once in contact with another stressor. Furthermore, we did not find any evidence that adaptation to alternating stressors was associated with additional adaption costs. This study highlights the need to incorporate adaptive cost assessments when undertaking ecological risk assessments of pollutants.

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Section: Discussionmentioning

confidence: 99%

Adaptation costs to constant and alternating polluted environments

Dutilleul

Réale

Goussen

et al. 2017

Evolutionary Applications

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“…Different experimental techniques have been devoted to investigate the metal complexes of GSH, such as electron paramagnetic resonance (EPR) [26,27], NMR [28,29], X-ray diffraction (X-ray) [30,31] and ESI-MS [32]. Nevertheless, it is difficult to explain the structures of the complexes at the atomic and electronic level.…”

Section: Introductionmentioning

confidence: 99%

Probing the coordination properties of glutathione with transition metal ions (Cr2+,Mn2+,Fe2+,Co2+, Ni2+,Cu2+,Zn2+,Cd2+,Hg2+) by density functional theory

Liu

et al. 2014

J Biol Phys

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Probing the coordination properties of glutathione with transition metal ions (Cr 2+,were larger than that of M-N and M-O; for Cr 2+ complexes, most of the WBIs of M-O in complexes were higher than that of M-S and M-N. Furthermore, the changes in the electron configuration of the metal cations before and after chelate reaction revealed that Cu 2+ , Ni 2+ , Co 2+ and Hg 2+ had obvious tendencies to be reduced to Cu + , Ni + , Co + and Hg + during the coordination process.

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“…Redox-inactive metals, including cadmium and zinc, also exert toxicity by binding with the sulfhydryl groups of proteins (Valko et al, 2016). Excess metals may also lead to the production of reactive species, including superoxide (O − 2 •), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO − ), hydroxyl radicals (OH•) and nitric oxide (NO), which may also produce damage in animal tissues (Stocker and Keaney, 2004;Aitken and Roman, 2008;Martinez-Finley and Aschner, 2011). In response, organisms have multiple different mechanisms for the detoxification of reactive oxygen or nitrogen species to minimize damage (Figure 3).…”

Section: Sub-lethal Impacts Of Chronic Exposure Should Be Consideredmentioning

confidence: 99%

Identifying Toxic Impacts of Metals Potentially Released during Deep-Sea Mining—A Synthesis of the Challenges to Quantifying Risk

et al. 2017

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In January 2017, the International Seabed Authority released a discussion paper on the development of Environmental Regulations for deep-sea mining (DSM) within the Area Beyond National Jurisdiction (the "Area"). With the release of this paper, the prospect for commercial mining in the Area within the next decade has become very real. Moreover, within nations' Exclusive Economic Zones, the exploitation of deep-sea mineral ore resources could take place on very much shorter time scales and, indeed, may have already started. However, potentially toxic metal mixtures may be released at sea during different stages of the mining process and in different physical phases (dissolved or particulate). As toxicants, metals can disrupt organism physiology and performance, and therefore may impact whole populations, leading to ecosystem scale effects. A challenge to the prediction of toxicity is that deep-sea ore deposits include complex mixtures of minerals, including potentially toxic metals such as copper, cadmium, zinc, and lead, as well as rare earth elements. Whereas the individual toxicity of some of these dissolved metals has been established in laboratory studies, the complex and variable mineral composition of seabed resources makes the a priori prediction of the toxic risk of DSM extremely challenging. Furthermore, although extensive data quantify the toxicity of metals in solution in shallow-water organisms, these may not be representative of the toxicity in deep-sea organisms, which may differ biochemically and physiologically and which will experience those toxicants under conditions of low temperature, high hydrostatic pressure, and potentially altered pH. In this synthesis, we present a summation of recent advances in our understanding of the potential toxic impacts of metal exposure to deep-sea meio-to megafauna at low temperature and high pressure, and consider the limitation of deriving lethal limits based on the paradigm Hauton et al.Identifying Toxic Impacts of Deep-Sea Mining of exposure to single metals in solution. We consider the potential for long-term and farfield impacts to key benthic invertebrates, including the very real prospect of sub-lethal impacts and behavioral perturbation of exposed species. In conclusion, we advocate the adoption of an existing practical framework for characterizing bulk resource toxicity in advance of exploitation.

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Revelations from the NematodeCaenorhabditis eleganson the Complex Interplay of Metal Toxicological Mechanisms

Cited by 46 publications

References 78 publications

Adaptation costs to constant and alternating polluted environments

Adaptation costs to constant and alternating polluted environments

Probing the coordination properties of glutathione with transition metal ions (Cr2+,Mn2+,Fe2+,Co2+, Ni2+,Cu2+,Zn2+,Cd2+,Hg2+) by density functional theory

Identifying Toxic Impacts of Metals Potentially Released during Deep-Sea Mining—A Synthesis of the Challenges to Quantifying Risk

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