Retrospective Study on the Prevalence and Antibiotic Resistance Pattern of Staphylococcus Aureus and Staphylococcus Epidermidis Among Patients Suspicious of Bacteremia During 2006 - 2011

Mohaghegh, Mohammad Ali; Ghazvini, Kiarash; Jafari, Rasool; Alikhani, Mohammad Yousef; Safari, Marzieh; Garamjan, Gholam Ali Azari; Falahi, Jamal; Bordbar, Davod

doi:10.17795/ijep22930

Cited by 9 publications

(8 citation statements)

References 22 publications

(16 reference statements)

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“…Unauthorized and illegal prescription of antibiotics is the main reason for the high prevalence of antibiotic resistance. Mohaghegh et al [18] reported that the prevalence of antibiotic resistance of the S. aureus strains against ampicillin, amoxicillin-clavulanic acid, cefepime, ceftazidime, nalidixic acid, and penicillin were 85%, 80%, 100%, 98.30%, 90.90%, and 90%, respectively. Moreover, the prevalence of resistance against tetracycline (51%), erythromycin (41.20%), oxacillin (97.70%), cephazolin (58.30), and norfloxacin (51.90%) was entirely high [18].…”

Section: Discussionmentioning

confidence: 99%

“…Mohaghegh et al [18] reported that the prevalence of antibiotic resistance of the S. aureus strains against ampicillin, amoxicillin-clavulanic acid, cefepime, ceftazidime, nalidixic acid, and penicillin were 85%, 80%, 100%, 98.30%, 90.90%, and 90%, respectively. Moreover, the prevalence of resistance against tetracycline (51%), erythromycin (41.20%), oxacillin (97.70%), cephazolin (58.30), and norfloxacin (51.90%) was entirely high [18]. Eladli et al [19] reported that the prevalence of antibiotic resistance of the S. epidermidis strains against amoxicillin-clavulanic acid, ciprofloxacin, clindamycin, erythromycin, gentamicin, levofloxacin, mupirocin, oxacillin, rifampin, tetracycline, and trimethoprim-sulfamethoxazole antibiotics was 100%, 100%, 37%, 0%, 33%, 16%, 0%, 80%, 0%, 80%, and 0%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran

Chabi

Momtaz

2019

Trop Med Health

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BackgroundResistant Staphylococcus epidermidis strains are considered to be one of the major causes of human clinical infections in hospitals. The present investigation was done to study the pattern of antibiotic resistance and the prevalence of virulence and antibiotic resistance genes amongst the S. epidermidis strains isolated from human hospital infections.MethodsOne hundred hospital infectious samples were collected and S. epidermidis strains were identified using culture and biochemical tests. Isolated strains were subjected to disk diffusion and PCR.ResultsForty-six out of 100 hospital infectious samples (46%) were positive for S. epidermidis. S. epidermidis strains harbored the highest prevalence of resistance against penicillin (95.65%), tetracycline (91.30%), erythromycin (82.60%), cefazolin (78.26%), and trimethoprim-sulfamethoxazole (73.91%). All S. epidermidis strains had resistance against at least three different types of antibiotics, while the prevalence of resistance against more than seven types of antibiotics was 17.39%. AacA-D (69.56%), tetK (56.52%), mecA (45.65%), msrA (39.13%), and tetM (39.13%) were most commonly detected antibiotic resistance genes. The prevalence of vatC (4.34%), ermA (8.69%), vatA (8.69%), vatB (13.04%), ermC (13.04%), and linA (10.86%) were lower than other detected antibiotic resistance genes. ClfA (32.60%), agrIII (17.39%), and etB (13.04%) were the most commonly detected virulence factors.ConclusionsThe presence of virulent and multi-drug resistance S. epidermidis strains showed an important public health issue in hospitals.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran

Chabi

Momtaz

2019

Trop Med Health

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“…The spreading of multi-drug resistant strains is one of the major challenges in healthcare all around the world, owing to difficult treatment. In a retrospective study by Mohaghegh et al in Iran from 2006 to 2011, antibiotic resistance increased among clinical S. aureus strains ( 34 ). In this study, the frequency of antimicrobial resistance was very high.…”

Section: Discussionmentioning

confidence: 99%

Distribution of tsst-1 and mecA Genes in Staphylococcus aureus Isolated From Clinical Specimens

Koosha

Hosseini

Aghdam

et al. 2016

Jundishapur J Microbiol

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Background: Staphylococcus aureus is a harmful pathogen known to express numerous virulence factors and cause severe infections. High levels of methicillin-resistant Staphylococcus aureus (MRSA) strains are one of the important healthcare problems because of the inefficient treatment of these infections. Objectives:The purpose of the current study is to evaluate the incidence of the toxic shock syndrome toxin (tsst-1) gene and its association with the prevalence of the mecA gene and drug resistance. Materials and Methods:The presence of the tsst-1 and mecA genes was investigated by polymerase chain reaction (PCR) among S. aureus isolated from 197 clinical samples. In addition, resistance tests to 12 antibiotics were carried out by the disc diffusion method. Results: Among the 197 isolates, 134 (68%) contained the tsst-1 genes and 172 (87.3%) contained the mecA genes. The prevalence of both genes was higher among male cases and samples purified from wounds and blood. We found no significant correlation between the presences of the two mentioned genes within isolates. The highest resistance we observed among our samples was to penicillin. None of isolates was resistant to vancomycin or linezolid. A significant correlation was observed between the presence of the mecA gene and resistance to oxacillin, gentamicin, kanamycin, erythromycin, tetracycline, cotrimoxazole, clindamycin, cephazolin and the multi-drug resistant property, which is resistance to more than three antibiotics (P < 0.05). Conclusions: Our outcomes showed elevated incidences of tsst-1 positive and MRSA strains with higher rates of antibiotic resistance. The conflict between our findings and other records may be due to differences in geographic regions.

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“…The research by Mohaghegh et al (2015) has demonstrated efficiency in using chloramphenicol against S. aureus isolates sampled from the patients with suspected bacteremia. In our study, the proportion of chloramphenicol-resistant isolates was high in both regions in certain years.…”

Section: Discussionmentioning

confidence: 99%

Hematological parameters and protein metabolism in the blood of pregnant rats under the effect of vanadium citrate

Klymets

Iskra

Svarchevska

2021

Regul. Mech. Biosyst.

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Dose-dependent changes in protein metabolism in the blood and hematological parameters of pregnant rats under the effect of vanadium citrate are presented in the article. The animals were divided into five groups: group I – non-pregnant females, II – pregnant females consuming pure water without additives, III, IV, V – females which during the mating and pregnancy period received the solution of vanadium citrate at concentrations of 0.03, 0.125 and 0.50 μg V/mL water. The research findings show that in pregnant animals of group II, the level of urea and alkaline phosphatase activity increased, meanwhile aspartate aminotransferase activity decreased, as compared to the non-pregnant females of group І. The levels of total protein and albumin decreased; however, the content of β-globulins increased in the pregnant animals of group II, as compared with that in group I. Also, in the rats of group II, there was a decrease in hemolysis time, total content of erythrocytes and hemoglobin, the content of old and mature erythrocytes, while the content of young erythrocytes increased, as compared to group I. The platelet content and thrombocrit in rats of group II increased in comparison with group I. The content of leukocytes and lymphocytes in pregnant animals of group II decreased, while the content of granulocytes increased, in contrast to non-pregnant rats. Under the effect of vanadium citrate at concentrations of 0.03–0.50 μg V/mL, there was a significant increase in the maximum number of prohemolized erythrocytes, the time of maximum hemolysis was delayed by 0.4–0.6 min, as compared with the pregnant rats of group II. This did not affect the time of total hemolysis in rats of groups III and V, as compared with the pregnant animals in group II. Under the effect of vanadium citrate, an increase in the content of young erythrocytes was observed, as compared with group II. The hemoglobin content decreased at the concentration of 0.125 μg V/mL, while at the concentration of 0.50 μg V/mL it increased, as compared to the pregnant animals of group II. Also, under the effect of vanadium citrate there was a decrease in the mean hemoglobin concentration in the erythrocyte. In pregnant animals fed with vanadium citrate solutions, the platelet content and thrombocrit, the relative width of platelet distribution by volume decreased, as compared with the pregnant rats of group II. The content of leukocytes, lymphocytes and granulocytes under the effect of vanadium citrate increased, as compared with the pregnant animals in group II. Under the effect of vanadium citrate at the concentration of 0.03 μg V/mL, the level of albumin, creatinine and aspartate aminotransferase activity increased in blood plasma in comparison with group II. Meanwhile, at the concentration of 0.125 μg V/mL, the relative content of γ-globulins and aspartate aminotransferase activity increased, alkaline phosphatase activity and urea level decreased in comparison with group II. However at the concentration of 0.50 μg V/mL, the relative α- and γ-globulins content and aspartate aminotransferase activity increased, at the same time, the relative β-globulins content and urea level decreased in comparison with group II. Therefore, vanadium citrate normalizes the indicators of protein metabolism during pregnancy, thus it can be considered as a potential dietary drug for the pregnant.

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Retrospective Study on the Prevalence and Antibiotic Resistance Pattern of Staphylococcus Aureus and Staphylococcus Epidermidis Among Patients Suspicious of Bacteremia During 2006 - 2011

Cited by 9 publications

References 22 publications

Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran

Virulence factors and antibiotic resistance properties of the Staphylococcus epidermidis strains isolated from hospital infections in Ahvaz, Iran

Distribution of tsst-1 and mecA Genes in Staphylococcus aureus Isolated From Clinical Specimens

Hematological parameters and protein metabolism in the blood of pregnant rats under the effect of vanadium citrate

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