Retrospective Study of Predictors of Bone Metastasis in Prostate Cancer Cases

Ho, Christopher C.K.; Seong, Poh Keat; Zainuddin, Zulkifli Md; Manaf, Mohd Rizal Abdul; Parameswaran, Muhilan; Razack, Azad Hassan Abdul

doi:10.7314/apjcp.2013.14.5.3289

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…However, according to our study, we can say that PSA levels below 10 ng/ mL do not pose a significant risk for bone metastasis and do not require bone scintigraphy, which also supports many other studies (8,(13)(14)(15).…”

Section: Discussionsupporting

confidence: 70%

Relationship Between Bone Scintigraphy Results and Gleason Scores and Prostate- Specific Antigen Levels

Şahin¹

2017

Istanbul Med J

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Prostate cancer (PCa) is the most common non-cutaneous cancer in men, especially in the U.S. and European countries, although it is seen at various frequencies depending on genetic and regional differences (1, 2). Because the surgical treatment is the most effective method for localized PCa, accurate staging in patients is very important in terms of treatment and therefore survival morbidity. The most common distant metastasis in PCa is bone metastases, and the majority of them have osteoblastic characteristics, and they can be detected with high accuracy through the whole-body bone scintigraphy with the technetium 99 m-methylene diphosphonate (Tc99m-MDP). Although scintigraphic method has advantages such as high sensitivity and a full body scanning in one step; due to their low specificity and cost disadvantages, there is still no clear consensus in all countries to use it in staging before the treatment in newly diagnosed patients with prostate cancer. If the prostate-specific antigen (PSA) is ≤20 ng/mL, the Gleason score (GS) is ≤7, and the patient has no additional complaint, there is no need for scintigraphic imaging for bone metastasis according to the guidelines of prostate cancer of the American and European Urology associations; however the prostate cancer guideline of the Japanese Urology Association does not accept this view (3-5). While the National Comprehensive Cancer Network (NCNN) recommends bone scintigraphy in clinical T3, T4 stage patients or in patients with bone symptoms, it has the opinion that bone scintigraphy should be performed if the PSA value is above 10 ng/mL or GS value is 8 or above in patients with the stage of T1 or T2 (6). As can be understood from these, it is controversial in which cases bone scintigraphy should be used in patients with PCa diagnosis.We aimed to reveal the relationship between bone scintigraphy results and the levels of GS and PSA in terms of the determination of metastasis in patients with PCa and to provide information about the necessity of using bone scintigraphy according to the results obtained. MethodsIn our study, scintigraphic images and file records (anamnesis, physical examination, PSA, GS, and radiological examination results, if any) of male patients who were histopathologically diagnosed with PCa and who came to our hospital's nuclear medicine department for whole-body bone scin- Relationship Between Bone Scintigraphy Results and Gleason Scores and Prostate-Specific Antigen LevelsIntroduction: We aimed to determine the relationship between bone scintigraphy results and Gleason score (GS) and prostate-specific antigen (PSA) levels in the detection of bone metastases in patients diagnosed with prostate cancer. Further, the predictive values of PSA levels and GSs were determined using bone scintigraphy.Methods: Seventy-three patients diagnosed with prostate cancer and who underwent bone scintigraphy for staging at our department between 2013 and 2015 were enrolled. The records of these patients were retrospectively reviewed for determining bone scin...

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Section: Discussionsupporting

confidence: 70%

Relationship Between Bone Scintigraphy Results and Gleason Scores and Prostate- Specific Antigen Levels

Şahin¹

2017

Istanbul Med J

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“…The demographic profile,clinical details, bone scan results of the patient population of our study matches numerous studies conducted in relation to prostatic carcinoma. [6][7][8][9][10][11][12][13][14][15][16][17] The mean pretreatment PSA levels in various studies was different with a wide range.A study by Alpeshpuri et al [18] found a low value, of about 20.33ng/ml while a study by Albasri et al [19] reported serum PSA as high as 363.4ng/ml in CaP.In our study mean PSA level in prostate carcinoma was 128ng/ml. We had one case below the cutoffsPSA value.…”

Section: Discussionmentioning

confidence: 99%

Histopathological Study of Prostatic Carcinoma in Relation to Gleason Grade, Serum PSA and Ki67 Immunomarker

Mahadev

Vani

Murthy

2018

APALM

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“…They found that PSA, GS, clinical stage, and percentage of positive biopsy cores were all associated with bone metastasis. Ho et al assessed 90 patients with bone metastasis and found that PSA level and nodal status were the two independent variables to predict bone metastasis in newly diagnosed PCa . In a more recent review article, the majority of the included studies showed that, GS, tPSA and clinical stage all had significant impact on metastasis to the skeletal system .…”

Section: Discussionmentioning

confidence: 99%

Perineural invasion in prostate biopsy specimens is associated with increased bone metastasis in prostate cancer

et al. 2015

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Retrospective Study of Predictors of Bone Metastasis in Prostate Cancer Cases

Cited by 9 publications

References 25 publications

Relationship Between Bone Scintigraphy Results and Gleason Scores and Prostate- Specific Antigen Levels

Relationship Between Bone Scintigraphy Results and Gleason Scores and Prostate- Specific Antigen Levels

Histopathological Study of Prostatic Carcinoma in Relation to Gleason Grade, Serum PSA and Ki67 Immunomarker

Perineural invasion in prostate biopsy specimens is associated with increased bone metastasis in prostate cancer

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