Histopathological Study of Prostatic Carcinoma in Relation to Gleason Grade, Serum PSA and Ki67 Immunomarker

Mahadev, Kanna Sandhyarani; Vani, BR; Murthy, Srinivas V

doi:10.21276/apalm.1996

APALM

2018

DOI: 10.21276/apalm.1996

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Histopathological Study of Prostatic Carcinoma in Relation to Gleason Grade, Serum PSA and Ki67 Immunomarker

Kanna Sandhyarani Mahadev

BR Vani

Srinivas V Murthy

Abstract: Samples-This study was conducted over a period of 18 months (Nov 2013 to April 2015).A total of 100 patients with diagnosis of prostatic carcinoma on biopsies and transrectal urethral resection specimens(TURP) were included in the study. All tumor samples were routinely processed. The patient's medical records were reviewed to

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2022

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Cited by 2 publications

References 25 publications

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Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

Varma¹,

Jindal²,

Sharda³

et al. 2022

ann urol oncol

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Background Prostate cancer (PCa) is the second most frequent malignancy (after lung cancer) in men worldwide .In prostate cancer, immunohistochemistry (IHC) has an important role in the diagnostic confirmation. Gleason score, tumour volume, surgical margins and Ki-67 index are the most significant prognostic factors. The value of different biomarkers like p53, Ki-67, PSMA, androgen receptor mutations, IGF, E-cadherin remains to be applied in clinical practice. In the present study we studied the expression of PSMA and Ki 67 IHC marker in prostatic carcinoma cases and its relation with Gleason score and Gleason grade group of tumour. Method A total of 52 cases of prostate carcinoma diagnosed on histopathology as adenocarcinoma in the Department of surgical pathology within 2.5 years duration were further studied immunohistochemically by PSMA and Ki 67 antibodies. Results At the time of presentation most of the cases have serum PSA level 11-50 ng/ml and with increasing Gleason score it can be ≥100ng/ml. Majority of cases have Gleason score 7 and the most common Gleason grade group is 2. PSMA and Ki 67 IHC marker is significantly correlated with Gleason score and Gleason grade group. PSMA expression is significantly correlated with perineural invasion and Ki 67 with bone metastasis. Conclusion PSMA and Ki 67 IHC marker can be used in conjunction with or as a substitute to Gleason scoring system for proper risk.

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Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

Varma¹,

Jindal²,

Sharda³

et al. 2022

ann urol oncol

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EVALUATION OF Ki-67 IN PROSTATIC CARCINOMA AND ITS CORRELATION WITH GLEASON'S SCORE AND OTHER PROGNOSTIC FACTORS

Singh¹,

Pant²,

Pandey³

et al. 2022

ijsr

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Background&Objectives: Prostate cancer is the second most commonly diagnosed malignancy and sixth leading cause of cancer death among men globally. Gleason system is the one recommended by World health organization and accepted by majority of urologists and radiotherapists. Proliferation marker Ki-67 reects the tumor cell proliferation rate as it correlates with progression, metastasis and prognosis in a number of different malignancies. The objective is to assess different histopathological grades and ki67 protein expression in prostate carcinoma and to correlate ki67 with Gleason's grade and other prognostic factors. Methods: The Prospective study was carried out in the Department of Pathology of SRMSIMS, Bareilly over a period of 1.5 years from November 2019 to April 2021.47 histologically conrmed prostatic carcinoma cases were included. They were subjected to immunohistochemical staining for ki67 and its activity was quantied using the labeling index. Result: In this study, expression of ki67 was markedly high in tumours with increased Gleason's grade group and was found to be statistically signicant( p value= 0.042). No statistically signicant correlation was seen with USG ndings, S. PSA, lymphovascular and perineural invasion.(p value= 0.452, 0.587, 0.051, 0.320). Interpretation&Conclusion: Ki67 expression is signicantly upregulated in aggressive and high grade prostatic carcinomas which reects its crucial relationship with the prognosis of these cancers.

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Histopathological Study of Prostatic Carcinoma in Relation to Gleason Grade, Serum PSA and Ki67 Immunomarker

Cited by 2 publications

References 25 publications

Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

Study of Immunohistochemical Marker Psma and Ki 67 Expression and Its Relation with Grading in Prostate Carcinoma

EVALUATION OF Ki-67 IN PROSTATIC CARCINOMA AND ITS CORRELATION WITH GLEASON'S SCORE AND OTHER PROGNOSTIC FACTORS

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