Retrospective Comparison of Diabetic Foot Ulcer and Venous Stasis Ulcer Healing Outcome Between a Dermal Repair Scaffold (PriMatrix) and a Bilayered Living Cell Therapy (Apligraf)

Karr, Jeffrey C.

doi:10.1097/01.asw.0000395038.28398.88

Cited by 33 publications

(14 citation statements)

References 25 publications

(20 reference statements)

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“…In contrast, the intact collagen is resistant to lymphocyte action and is retained longer in the wound bed acting as an exogenous matrix (55). Another shortcoming of fractionated and subsequently cross-linked collagen is its densely packed structure that prevents penetration of fibroblasts and their interaction with the collagen matrix (56).…”

Section: Collagenbased Medical Devices and Productsmentioning

confidence: 99%

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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The treatment of chronic wounds is a continuously developing research focus. The problems of excessive mechanical forces, infection, inflammation, reduced production of growth factors, and lack of collagen will affect the results of treatment. The purpose of this study was to analysse the elements that lead to long-term non-healing of chronic wounds and trophic ulcers, including diabetic foot syndrome, by determining the optimal treatment algorithm. The paper presents an analysis of the world literature on the etiopathogenesis and principles of chronic wound treatment in diabetic foot syndrome. The epidemiology of chronic wounds of different genesis is presented. The issues of physiological and metabolic disorders in chronic ulcers affecting the process of wound healing are discussed. Particular attention is paid to collagen, which is a protein that forms the basis of connective tissue; collagen ensures the strength and elasticity of the skin, which confirms the importance of its role not only in aesthetics but also in the process of wound healing. Different types of collagen and their roles in the mechanisms of chronic wound healing in diabetic foot syndrome are described. The results of clinical studies evaluating the effectiveness of medical products and preparations, consisting of collagen with preserved (native collagen) and fractionated structures, in treating chronic wounds of diabetic foot syndrome are analysed. It has been shown that the use of native collagen preparations is a promising treatment for chronic ulcers and wounds, including diabetic foot syndrome, which makes it possible to increase the effectiveness of treatment and reduce the economic costs of managing these patients.

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Section: Collagenbased Medical Devices and Productsmentioning

confidence: 99%

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Stupin

Gabitov

Sinel’nikova

et al. 2018

Serbian Journal of Experimental and Clinical Research

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“…Both terminally differentiated dermal cells and stem cells have been used extensively in skin and hair follicle regeneration. The FDA-approved product Apligraf (Organogenesis, Canton, MA, http://www.organogenesis.com) consists of dermal fibroblasts seeded onto collagen type I and overlaid by keratinocytes and showed promising results in clinical trials for treatment of chronic skin wounds associated with diabetes [81]. Many current efforts also use HFP and bulge cells (Fig.…”

Section: Dscs In Tissue Engineering and Regenerative Medicinementioning

confidence: 99%

Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine

Vapniarsky

Arzi

et al. 2015

Stem Cells Translational Medicine

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“…It is FDA approved for chronic wound conditions like venous leg ulcers and diabetic foot ulcers [69]. However it is an allogeneic product and is prone to immune-mediated rejection.…”

Section: Therapeutic Indicationsmentioning

confidence: 99%

Alteration of Skin Properties with Autologous Dermal Fibroblasts

Thangapazham

Darling

Meyerle

2014

IJMS

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Dermal fibroblasts are mesenchymal cells found between the skin epidermis and subcutaneous tissue. They are primarily responsible for synthesizing collagen and glycosaminoglycans; components of extracellular matrix supporting the structural integrity of the skin. Dermal fibroblasts play a pivotal role in cutaneous wound healing and skin repair. Preclinical studies suggest wider applications of dermal fibroblasts ranging from skin based indications to non-skin tissue regeneration in tendon repair. One clinical application for autologous dermal fibroblasts has been approved by the Food and Drug Administration (FDA) while others are in preclinical development or various stages of regulatory approval. In this context, we outline the role of fibroblasts in wound healing and discuss recent advances and the current development pipeline for cellular therapies using autologous dermal fibroblasts. The microanatomic and phenotypic differences of fibroblasts occupying particular locations within the skin are reviewed, emphasizing the therapeutic relevance of attributes exhibited by subpopulations of fibroblasts. Special focus is provided to fibroblast characteristics that define regional differences in skin, including the thick and hairless skin of the palms and soles as compared to hair-bearing skin. This regional specificity and functional identity of fibroblasts provides another platform for developing regional skin applications such as the induction of hair follicles in bald scalp or alteration of the phenotype of stump skin in amputees to better support their prosthetic devices.

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Retrospective Comparison of Diabetic Foot Ulcer and Venous Stasis Ulcer Healing Outcome Between a Dermal Repair Scaffold (PriMatrix) and a Bilayered Living Cell Therapy (Apligraf)

Abstract: Although both treatments were highly effective, the study results of 68 ulcers in 48 patients demonstrated that patients treated with PriMatrix healed faster than patients treated with Apligraf despite larger wound sizes.

Cited by 33 publications

References 25 publications

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Biological Mechanisms of Chronic Wound and Diabetic Foot Healing: The Role of Collagen

Concise Review: Human Dermis as an Autologous Source of Stem Cells for Tissue Engineering and Regenerative Medicine

Alteration of Skin Properties with Autologous Dermal Fibroblasts

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