The treatment of chronic wounds is a continuously developing research focus. The problems of excessive mechanical forces, infection, inflammation, reduced production of growth factors, and lack of collagen will affect the results of treatment. The purpose of this study was to analysse the elements that lead to long-term non-healing of chronic wounds and trophic ulcers, including diabetic foot syndrome, by determining the optimal treatment algorithm. The paper presents an analysis of the world literature on the etiopathogenesis and principles of chronic wound treatment in diabetic foot syndrome. The epidemiology of chronic wounds of different genesis is presented. The issues of physiological and metabolic disorders in chronic ulcers affecting the process of wound healing are discussed. Particular attention is paid to collagen, which is a protein that forms the basis of connective tissue; collagen ensures the strength and elasticity of the skin, which confirms the importance of its role not only in aesthetics but also in the process of wound healing. Different types of collagen and their roles in the mechanisms of chronic wound healing in diabetic foot syndrome are described. The results of clinical studies evaluating the effectiveness of medical products and preparations, consisting of collagen with preserved (native collagen) and fractionated structures, in treating chronic wounds of diabetic foot syndrome are analysed. It has been shown that the use of native collagen preparations is a promising treatment for chronic ulcers and wounds, including diabetic foot syndrome, which makes it possible to increase the effectiveness of treatment and reduce the economic costs of managing these patients.
Burn Center 2 ; Head of the 2 nd Burn Unit 2 ; G.V. Mirzoyan, Pediatric Surgeon, the 2 nd Burn Unit 2 ; R.B. Gabitov, Scientific Consultant, Department of Surgical Diseases and Clinical Angiology 3 ; M.A. Brazol, MD, PhD, Head of the Burn Unit; Deputy Chief Surgeon 4 ; P.V. Salistyj, Head of the Burn Unit 5 ; Y.V. Chikinev, MD, DSc, Professor, Head of the Department of Hospital and Pediatric Surgery 6 ; A.A. Shmyrin, Head of the Unit of Combustiology 7 ; A
The review of the world literature, is devoted to the role of collagen in the process of wound healing. The problems of epidemiology of chronic wounds and ulcers of various genesis, physiology and pathophysiology of wound healing phases are considered. The pathogeneticrole of different types of collagen, as well as the mechanisms of collagen, macrophage, fibroblasts, matrix metalloproteinases and other cytokines in healing ulcers are discussed. The prospects of development and use of medical products and preparations based on collagen in the treatment of patients with chronic wounds and ulcers are shown. The results of clinical studies on the effectiveness of collagen with preserved (native) and unsaved (fractionated) structure are presented. The advantages of using native collagen in the treatment of diabetic foot syndrome are demonstrated.
The results of an international prospective multicenter observational study are presented. Its purpose was to compare the dynamics of a wound process when using various forms of Collost medical device (gel 7%, membranes, powder) and traditional local conservative treatment with hydrocolloid dressings in children with burns of II–III degrees (ICD-10). 94 patients aged 1 to 12 years old with a mosaic thermal injury were included. The patients were divided into 3 groups depending on the type of collagen material. The fourth group (comparison group) was composed of patients with traditional local conservative management of wounds. The obtained results were compared. It was proven that the dynamics of wound area reduction and rate of its epithelization were the best when Collost collagen material was used. Collost as gel and as powder produces a special favorable effect on the course of the wound process in the presence of secondand third-degree burns.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.