Retrospective Analysis of the Beijing Family of Mycobacterium tuberculosis in Preserved Lung Tissues

Abstract

Direct repeat spoligotyping of 85 paraffin-embedded lung biopsies was used to investigated the occurrence around Beijing of the Beijing family of Mycobacterium tuberculosis. Samples ranged in time from 1956 to 1990. Hybridization patterns were found with 49 (58%) samples, and 45 (92%) produced typical Beijing family patterns extending over the 34-year period.

Drug resistance and genotypic analysis of Mycobacterium tuberculosis strains from Thai tuberculosis patients

“…However, there was a somewhat increased frequency of DR among the Beijing strains as compared with non-Beijing strains in our material. No difference of bacillary load between patients infected by Beijing compared with non-Beijing strains was noted, in contrary to what was indicated in a previous report (19). In a recent report from Thailand, 79% of RIF R strains were of Beijing genotype (20).…”

Laboratory Investigation of a Nosocomial Transmission of Tuberculosis at a District General Hospital

“…25 It is not surprising that Taiwan is geographically and economically closely related to Mainland China, which has a high prevalence rate of the Beijing genotype of M. tuberculosis. 26 Close surveillance of this prevalent strain is necessary to prevent any possible outbreaks in future. Nosocomial transmission of TB has been frequently reported, especially after the observed resurgence of the disease and the increased incidence of multidrug-resistant (MDR) TB in the 1990s.…”

The emergence of Beijing family genotypes ofMycobacterium tuberculosisand low-level protection by bacille Calmette–Guérin (BCG) vaccines: is there a link?

“…The study of Qian et al . [57], in which spoligotype was performed on paraffin-embedded material, indicated that the Beijing genotype was presumably already prevalent in the Beijing region 30-40 years ago.…”