Retrospective analysis of prognostic value of the neutrophil-to-lymphocyte ratio in early miscarriages

Kim, Youngsun

doi:10.1097/md.0000000000020888

Cited by 10 publications

(11 citation statements)

References 10 publications

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“…3,4 The physical and emotional health of a woman can be severely impacted by a miscarriage, and many studies have been conducted on the prediction and prevention. 5,6 A novel index called the systemic immune-inflammation index (SII) was developed based on the peripheral lymphocyte, neutrophil, and blood platelet counts evaluated for the prediction of adverse pregnancy outcomes. 7 In this study, we evaluate the clinical significance of the SII values of patients who had miscarriages.…”

Section: Introductionmentioning

confidence: 99%

“…Maternal age, ethnic origin, a very low or very high body mass index (BMI), stress, infection, drug use, smoking, and alcohol consumption have also been associated with miscarriage 3,4 . The physical and emotional health of a woman can be severely impacted by a miscarriage, and many studies have been conducted on the prediction and prevention 5,6 . A novel index called the systemic immune‐inflammation index (SII) was developed based on the peripheral lymphocyte, neutrophil, and blood platelet counts evaluated for the prediction of adverse pregnancy outcomes 7 .…”

Section: Introductionmentioning

confidence: 99%

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Predicting miscarriage using systemic immune‐inflammation index

Turgut

Yıldırım

Sakcak

et al. 2022

J of Obstet and Gynaecol

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Aim: To evaluate the clinical significance of the systemic immune-inflammation index (SII) for patients who had miscarriages. Materials: The retrospective study included 709 pregnant women who had a miscarriage (nonviable intrauterine pregnancy up to 20 weeks of gestation) and 676 women who carried a viable intrauterine pregnancy up to 20 weeks of gestation-serving as the control group. The study and the control group were compared in terms of demographic characteristics, laboratory test results, and SII values. Furthermore, laboratory test results and SII values were compared between patients in the study group and the control group with a history of genital bleeding (threatened abortion). Results: The mean gestational week of pregnancy was 9.5 AE 3 for the control group and 8.3 AE 2.5 for the study group (p = 0.150). The SII values were higher in the study group than in the control group (p = 0.030). In all participants with a clinical history of genital bleeding, the leukocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and SII values were higher in the miscarriage group than the group with viable fetus (p = 0.031, p = 0.003, p = 0.002, p < 0.001). Based on a receiver operating characteristic (ROC) curve analysis, the SII cutoff value for miscarriage was 883.95 (10 9 /L) (62.6% sensitivity, 62% specificity) in patients with a clinical history of threatened abortion. Conclusion: High SII values in early pregnancy may be used as an additional marker for the prediction of miscarriage, in pregnant women with threatened abortion. Further prediction models including maternal risk factors and multiple markers may be more valuable for clinical practice.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting miscarriage using systemic immune‐inflammation index

Turgut

Yıldırım

Sakcak

et al. 2022

J of Obstet and Gynaecol

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“…Conversely, the study of Kim (17) , revealed significantly lower NLR in patients with missed abortion when compared to patients with threatened abortion. However, Biyik et al (18) reported significantly higher NLR in missed abortion group as compared to normal pregnancy group (P 0.038).…”

Section: Discussionmentioning

confidence: 85%

Role of Inflammatory Markers in the Differential Diagnosis of Bleeding in Early Pregnancy

Ahmedy¹,

Solyman²,

Hosni³

2021

The Egyptian Journal of Hospital Medicine

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Background: Defective placentation as a cause of many pregnancy-related conditions including abortion and ectopic pregnancy will involve abnormal inflammatory response. Assessment of different inflammatory markers as neutrophillymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR) may aid in the differentiation of causes of bleeding in early pregnancy. Objective: To verify the ability of NLR, PLR, and LMR to differentiate cases of miscarriage or ectopic pregnancy from normal pregnancy in patients presenting with bleeding in the first trimester. Patients and Method: A prospective observational study of 150 patients presenting with bleeding in the first trimester were enrolled in the study. After history taking, clinical examination, ultrasound, quantitative beta-human chorionic gonadotropin (B-hCG), or laparoscopy, patients were allocated into three groups: miscarriage group (60 patients), ectopic pregnancy group (30 patients), and control group (60 patients) who continued their pregnancy beyond 20 weeks. For all patients NLR, PLR, and LMR were calculated. Results: NLR was significantly higher and LMR was significantly lower in ectopic pregnancy group when compared to the miscarriage group or the normal pregnancy group. A cutoff level of > 2.7 for NLR and < 3.7 for LMR has a sensitivity of 80% and 70%, and a specificity of 60 % and 80 %, respectively. Conclusion: Utilization of both NLR and LMR will aid in the differentiation of cases of ectopic pregnancy from normal pregnancy or miscarriage with an acceptable sensitivity and specificity.

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“…Biyik et al 35 showed that NLR and PLR values were higher in the missed miscarriage group than in the healthy pregnant women group. Kim et al 36 showed that NLR was the prognostic factor for distinguishing between the missed abortion and threatened abortion. In contrast to these studies, we found that the NLR and PLR values were similar in missed miscarriage and normal pregnancy group ( p > 0.05).…”

Section: Discussionmentioning

confidence: 99%

Predictive value of NLR and PLR in missed miscarriage

Liú

Huang

et al. 2022

Clinical Laboratory Analysis

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Background:The aim of the study was to investigate the predictive value of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in missed miscarriage. Methods:In this retrospective cohort study, a total of 400 women (involving 200 with missed early miscarriage and 200 with normal pregnancy but terminate by artificial abortion) were included. General clinical data and complete blood count (CBC) such as white blood cells (WBC), red blood cells (RBC), platelet (PLT), red blood cell distribution width-standard deviation (RDW-SD), platelet distribution width (PDW), mean platelet volume (MPV), neutrophil count, and lymphocyte count were collected, and the NLR and PLR were calculated for both groups. Receiver operating characteristic curve (ROC) was used to calculate the predictive value.Results: There was no significant difference in the WBC, RBC, PLT, RDW-SD, PDW, neutrophil, lymphocyte, NLR, and PLR between the two groups (p > 0.05).But MPV was lower in the missed early miscarriage group than in the control group (p < 0.05), and the area under the working curve (AUC) of ROC was 0.58, specificity and sensitivity was 69% and 47%, respectively. Conclusion:NLR and PLR were not the suitable indictor for missed miscarriage, but MPV should be a concern in the first trimester.

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Retrospective analysis of prognostic value of the neutrophil-to-lymphocyte ratio in early miscarriages

Cited by 10 publications

References 10 publications

Predicting miscarriage using systemic immune‐inflammation index

Predicting miscarriage using systemic immune‐inflammation index

Role of Inflammatory Markers in the Differential Diagnosis of Bleeding in Early Pregnancy

Predictive value of NLR and PLR in missed miscarriage

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