Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

Abstract

Background: Soft tissue sarcomas (STS) must be managed with a team involving pathologists, radiologists, surgeons, radiation therapists and medical oncologists. Treatment modalities and demographic charasteristics of Turkish STS were analysed in the current study. Material-Methods: Primary adult STS followed between 1999-2010 in Cukurova University Medical Faculty Department of Medical Oncology were analzied retrospectively Results: Of the total of 498 patients, 238 were male and 260 female. The most seen adult sarcomas were leomyosarcoma (23%). Localization of disease was upper extremity (8.8%), lower extremity (24.7%), head-neck 8.2%, thoracic 8%, retroperitoneal 5.6%, uterine 12.4%, abdominal 10%, pelvic region 3.6 and other regions 10%. Some 13.1% were early stage, 10.2% locally advanced, 8.2% metastatic and 12.2% recurrent disease. Patients were treated with neoadjuvant/adjuvant (12%) or palliative chemotherapy (7.2%) and 11.4% patients did not receive chemotherapy. Surgery was performed as radical or conservative. The most preferred regimen was MAID combination chemotherapy in the rate of 17.6%. The most common metastatic site was lung (18.1%). The overall survival was 45 months (95%CI 30-59), 36 months in men and 55 months in women, with no statistically significant difference (p=0.5). The survival rates were not different between the group of adjuvant and palliative chemotherapy (respectively 28 versus 18 months) (p=0.06), but radical surgery at 37 months was better than 22 months for conservative surgery (p=0.0001). No differences were evident for localization (p=0.152). Locally advanced group had higher overall survival rates (72 months) than other stages (p=0.0001). Conclusion: STS can be treated successfully with surgery, chemotherapy and radiotherapy. The survival rates of Turkish people were higher in locally advanced group; these results show the importance of multimodality treatment approach and radical surgery.

Clinicopathologic characteristics, treatment outcomes, and prognostic factors of primary thoracic soft tissue sarcoma: A multicenter study of the Anatolian Society of Medical Oncology (ASMO)

“…Meanwhile, resectability has emerged as an important prognostic factor in thoracic STS, as well as all other types of STS. 28 Other prognostic factors, such as tumor grade, diameter, and stage were similar to those detected in previous large STS series. 2 , 4 , 20 , 21 , 26 However, among patients with resectable tumors, thoracic STS patients might have better prognostic characteristics.…”

Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma

“…Endostar combined with chemotherapy resulted in a higher disease control rate and longer progression-free survival (Zhang et al, 2013). In the study of Asia-Pacific region, specialists suggest RPLS be multi-disciplinarily managed with a team involving pathologists, radiologists, surgeons, radiation therapists and medical oncologists because of the different histotypes, sites, and disease stages assessed (Duman et al, 2012).…”

The Concomitant Use Of Proton Pump Inhibitors And Pazopanib In Patients With Soft-Tissue Sarcoma: Is It Really To Be Avoided?

“…When we searched the literature on this issue, we could not obtain precise data on the prognostic value of uterine localization of the tumor in patients with STS. In a retrospective of patients with STS, it was reported that there was no relationship between localization of the tumor and survival 20 . However, leiomyosarcoma is the most common histological subtype of STS located at the uterus, and it has been reported that patients receiving pazopanib for leiomyosarcoma have better results than the patients with other histological subtypes in terms of PFS and OS 19 .…”