Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma

Lü, Jing; Qin, Qin; Zhan, Liang-Liang; Yang, Xi; Qing, XU; Yu, Jing; Lina, Dou; Zhang, Hao; Yang, Yan; Chen, Xiaochen; Yu, Yan; Cheng, Hongyan; Sun, Xinchen

doi:10.7314/apjcp.2014.15.15.6041

Cited by 11 publications

(15 citation statements)

References 27 publications

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“…Our findings agree with Kim and colleagues, who concluded based on pathology in 4 of 10 patients that ground-glass nodules may be related to myxoid components 24 . It is known that a combination of water density and high-density areas, similar to that in the adjacent muscle, may be related to a fibromyxoid/myxoid component 29, 36 and not necessarily dedifferentiation and this correlated with our results.…”

Section: Discussionsupporting

confidence: 89%

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Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma?

Bhosale

Wang

Varma

et al. 2016

Journal of Computer Assisted Tomography

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Purpose To assess the ability of CT to differentiate an atypical lipomatous tumor (ALT)/well-differentiated liposarcoma (WDLPS) from a WDLPS with a dedifferentiated component (DDLPS) within it. Materials and Methods Forty-nine untreated patients with abdominal atypical lipomatous tumors/well-differentiated liposarcomas who had undergone contrast-enhanced CT were identified using an institutional database. Three radiologists who were blinded to the pathology findings evaluated all the images independently to determine whether a dedifferentiated component was present within the WDLPS. The CT images were evaluated for fat content (≤25% or >25%); presence of ground-glass density, enhancing and/or necrotic nodules; presence of a capsule surrounding the mass; septations; and presence and pattern of calcifications. A multivariate logistic regression model with generalized estimating equations was used to correlate imaging features with pathology findings. Kappa statistics were calculated to assess agreement between the three radiologists. Results On the basis of pathological findings, 12 patients had been diagnosed with DDLPS within a WDLPS and 37 had been diagnosed with WDLPS. The presence of an enhancing or a centrally necrotic nodule within the atypical lipomatous tumor was associated with dedifferentiated liposarcoma (p = 0.02 and p = 0.0003, respectively). The three readers showed almost perfect agreement in overall diagnosis (kappa r = 0.83; 95% confidence-interval 0.67 to 0.99). Conclusion An enhancing or centrally necrotic nodule may be indicative of a dedifferentiated component in well-differentiated liposarcoma. Ground-glass density nodules may not be indicative of dedifferentiation.

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Section: Discussionsupporting

confidence: 89%

“…Imaging can help identify appropriate areas for biopsy 39 . In addition, our findings (and the findings of others) indicate that if a ground-glass density area is biopsied with a negative pathology result for dedifferentiation, the biopsy may still be accurate as this nodule may represent a fibromyxoid component of ALT 29, 36 .…”

Section: Discussionsupporting

confidence: 65%

Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma?

Bhosale

Wang

Varma

et al. 2016

Journal of Computer Assisted Tomography

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“…Liposarcoma is a malignant tumor that consists of differentiated fat cells and the second highest soft tissue sarcoma in adults. 1,2 Prevalence of liposarcoma reached 15% to 25% of all sarcomas. 3 Histologically, the World Health Organization (WHO) classifies liposarcoma into five subtypes, namely atypical lipomatous tumor/well differentiated, dedifferentiated, myxoid, pleomorphic and liposarcoma not otherwise specified.…”

Section: Introductionmentioning

confidence: 99%

“…4 Clinically, liposarcoma is difficult to be diagnosed because it grows slowly and silently with no typical symptoms. 1 Hence, a pathology examination is very important to diagnose liposarcoma. Liposarcoma usually occurs in the retroperitoneum and extremities.…”

Section: Introductionmentioning

confidence: 99%

“…Liposarcoma usually occurs in the retroperitoneum and extremities. 1,[5][6][7][8] Retroperitoneal liposarcomas are difficult to treat and have higher rates of local recurrence, moreover it may cause death from uncontrolled local effects. 6,9 If the tumor is very large, it may cause abdominal discomfort, abdominal pain, weight loss, gastrointestinal bleeding, even kidney failure.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of Liposarcoma Patients: 5-Year Data

Rahmah

Afiati

Sugiri

2018

amj

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Background: Liposarcoma is the second highest soft tissue sarcoma in adults with prevalence of 15% to 25%. If the size of liposarcoma is very large, it may cause abdominal pain, weight loss, gastrointestinal bleeding, even kidney failure. Therefore, for early detection of liposarcoma, the characteristics of liposarcoma should be investigated. This study aimed to determine liposarcoma characteristics based on age, sex, location and histopathologic type according to WHO (World Health Organization) Classification of Tumors 2013.

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Incidentally discovered well-differentiated retroperitoneal liposarcoma with inguinal canal herniation: report of 2 cases

Fiaschetti

Castellani

Croce

et al. 2017

Radiology Case Reports

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Computed Tomography Manifestations of Histologic Subtypes of Retroperitoneal Liposarcoma

Cited by 11 publications

References 27 publications

Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma?

Can Abdominal Computed Tomography Imaging Help Accurately Identify a Dedifferentiated Component in a Well-Differentiated Liposarcoma?

Characteristics of Liposarcoma Patients: 5-Year Data

Incidentally discovered well-differentiated retroperitoneal liposarcoma with inguinal canal herniation: report of 2 cases

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