Retroperitoneal Schwannomas of Renal and Pararenal Origin: Presentation of Two Case Reports

Herden, Jan; Drebber, Uta; Ural, Yasemin; Zimmer-Chevret, Sandra; Wille, Sebastian; Engelmann, U.

doi:10.4081/rt.2015.5616

Cited by 7 publications

(12 citation statements)

References 13 publications

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“…Herden et al reported 27 cases of retroperitoneal schwannoma [8]. Malignant schwannomas can also occur in the stomach, the retroperitoneum and the head, and they can also be part of the Carney complex.…”

Section: Discussionmentioning

confidence: 99%

“…In asymptomatic cases or patients whose surgery poses a high risk, radiologic surveillance or radiofrequency ablation could be an option of therapy [8]. Strauss et al reported a study of eight patients undergoing a biopsy with conservative treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Nuclear-free zones can also be found within the regions of nuclear palisading (Verocay's bodies). Other features suggestive of schwannoma are the presence of hyalinised vessels and infiltration of macrophages [8,9,12]. Adrenal schwannomas present nuclear atypia which should not be confused with malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…Definitive diagnosis is based on surgically resected specimens [8]. Macroscopically, schwannomas are a well-circumscribed solid mass attached to a peripheral nerve.…”

Section: Discussionmentioning

confidence: 99%

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Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Fernández

Villamil

Fernández-Pello

et al. 2016

World J Nephrol Urol

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Schwannoma is a rare slow-growing neurogenic tumor of the nerve sheath origin. They are commonly seen in middle-aged with a female to male ratio of 1:1.2. Here we present three cases of retroperitoneal schwannoma in our urology department. In two cases, we decided surgery management and in one case, we used watchful waiting. After a 3-year follow-up, case 1 was asymptomatic without changes in the lesion. Keywords: Schwannoma; Retroperitoneal malignance; Neurogenic tumor IntroductionSchwannoma is a slow-growing neurogenic tumor of the nerve sheath origin. They are commonly seen in middle-aged with a female to male ratio of 1:1.2. Visceral schwannomas are infrequent. Computerized tomography (CT) images present areas of cystic degeneration, calcification or hemorrhage. Extension of the mass along the nerve may indicate the neural origin of the mass. It is important to exclude a malignant retroperitoneal tumor to choose the correct treatment.Here we present three cases of retroperitoneal schwannoma in our urology department. Case Reports Case 1A 54-year-old female smoker presented in our department with back pain on the right. Abdominal ultrasound and CT with contrast revealed a 4.2 × 3.2 cm mass located in the retrocaval area and medial to the right kidney (Fig. 1). The findings of the images were compatible with pheochromocytoma or paraganglioma. Biochemical workup included plasma and urine catecholamine. All studies were normal. The imagingguided biopsy was done. Microscopic findings showed a mass composed of fusiform cells with abundant collagen and spaces with macrophages. No mitoses were observed. Immunohistochemistry showed that the tumor cells were positive for S-100, BCL2, CD56, CD99 and negative for CD34 and muscle specific actin and desmin. The Ki67 activity was 1%. These findings were consistent with benign schwannoma.Because it was a benign case with small mass and the patient was asymptomatic, we decided watchful waiting with radiological periodic controls. Case 2A 56-year-old woman smoker was dispatched to the hematology department with thrombocytopenia after a routine health

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Definitive diagnosis is based on surgically resected specimens [8]. Macroscopically, schwannomas are a well-circumscribed solid mass attached to a peripheral nerve.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Fernández

Villamil

Fernández-Pello

et al. 2016

World J Nephrol Urol

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“…The Antony A pattern is characterized by a cell-rich structure with cell nuclei running parallel to each other while the Antony B pattern has a loose distribution of the cells with varying degrees of myxoid and hyaline degeneration. Immunohistochemically, S100 is an important marker for the diagnosis of schwannomas (8).…”

Section: Discussionmentioning

confidence: 99%

Giant posterior pararenal schwannoma: A�case report and review of literature

Peng

Zhou

et al. 2018

mol clin onc

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Schwannomas, arising from Schwann cells of peripheral nerve sheaths, are primarily benign tumors. They are rarely found in the retroperitoneal space. To date, ~30 cases on giant retroperitoneal schwannomas have been reported. Those with a location of pararenal space are even rarer. Clinically, they are often misdiagnosed as malignancies. In the present study, a case of a 35-year-old woman with a giant schwannoma measuring 13 × 8.5 × 6.5 cm in the posterior pararenal space of left retroperitoneum was presented, which was thought to be a malignant tumor from the result of computed tomography scan. Later postoperative pathology and immunohistochemistry were consistent with benign schwannoma. To the best of our knowledge, this was the largest posterior pararenal schwannoma reported in literature. It is significant to report this case, and summarize the characteristics, diagnosis, treatment and prognosis of the similar cases. Furthermore, a brief review of the previously published cases in literature is provided.

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Juxta-adrenal schwannoma presenting as a giant adrenal tumor: A case report and a literature review

Abdessater

Mokdad

Gas

et al. 2018

International Journal of Surgery Case Reports

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Retroperitoneal Schwannomas of Renal and Pararenal Origin: Presentation of Two Case Reports

Abstract: Retroperitoneal schwannomas are a rare entity. They originate from the Schwann cells of the nerve sheaths and may be of renal or pararenal origin. We report on two patients with retroperitoneal schwannomas, who received surgery under the suspicion of renal cell carcinoma.

Cited by 7 publications

References 13 publications

Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Management of Retroperitoneal Schwannoma: Case Reports and Review of the Literature

Giant posterior pararenal schwannoma: A�case report and review of literature

Juxta-adrenal schwannoma presenting as a giant adrenal tumor: A case report and a literature review

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