Retracted: The human placenta is a hematopoietic organ during the embryonic and fetal periods of development

Bárcena, Alicia; Kapidzic, Mirhan; Muench, Marcus O.; Gormley, Matthew; Scott, Jake; Weier, Jingly F.; Ferlatte, Christy; Fisher, Susan J.

doi:10.1016/j.ydbio.2008.11.017

Cited by 53 publications

(50 citation statements)

References 49 publications

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“…The contribution of the avian embryo model was pivotal in revealing the critical role of the embryonic compartment and the aorta in the generation of adult type HSCs, thereafter demonstrated in the mouse and human embryo (Godin et al, 1993;Medvinsky et al, 1993;Tavian et al, 1996). It has also pointed to the allantois as a new hematopoietic organ (Caprioli et al, 1998;Caprioli et al, 2001) a finding confirmed in the mouse embryo (Alvarez-Silva et al, 2003;Corbel et al, 2007;Gekas et al, 2005;Ottersbach and Dzierzak, 2005;Zeigler et al, 2006) and very recently in the human embryo (Barcena et al, 2009;Robin et al, 2009). Finally it has allowed demonstrating the role of the somite in shaping the aorta and controlling hematopoiesis.…”

Section: Resultsmentioning

confidence: 78%

Aortic remodelling during hemogenesis: is the chicken paradigm unique?

Jaffredo

Richard²,

Pouget³

et al. 2010

Int. J. Dev. Biol.

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Since the era of the ancient Egyptians and Greeks, the avian embryo has been a subject of intense interest to visualize the first steps of development. It has served as a pioneer model to scrutinize the question of hematopoietic development from the beginning of the 20th century. It's large size and easy accessibility have permitted the development of techniques dedicated to following the origins and fates of different cell populations. Here, we shall review how the avian model has brought major contributions to our understanding of the development of the hematopoietic system in the past four decades and how these discoveries have influenced our knowledge of mammalian hematopoietic development. The discovery of an intra-embryonic source of hematopoietic cells and the developmental link between endothelial cells and hematopoietic cells will be presented. We shall then point to the pivotal role of the somite in the construction of the aorta and hematopoietic production and demonstrate how two somitic compartments cooperate to construct the definitive aorta. We shall finish by showing how fatemapping experiments have allowed the identification of the tissue which gives rise to the subaortic mesenchyme. Taken together, this review aims to give an overview of how and to what extent the avian embryo has contributed to our knowledge of developmental hematopoiesis.

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Section: Resultsmentioning

confidence: 78%

Aortic remodelling during hemogenesis: is the chicken paradigm unique?

Jaffredo

Richard²,

Pouget³

et al. 2010

Int. J. Dev. Biol.

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“…All these approaches have suggested that discrete subsets of vascular ECs transiently exhibit blood-forming potential during vertebrate development. Recently a novel perspective to HSCs development came with the discovery that the human and murine placenta harbor a large pool of multipotential hematopoietic progenitors and stem cells, indicating that the placenta could play an important role in the establishment of hematopoiesis (Barcena et al, 2009;Robin et al, 2009;Mikkola et al, 2005; see also Ottersbach and Dzierzak; Mikkola, Dieterlen-Lièvre et al, in this issue). This process of HSCs emergence in the placenta is also intimately associated with large vessels (Rhodes et al, 2008) and therefore do highlight the role of vascular ECs in the generation of HSCs in vertebrates not only in the AGM, the umbilical and vitelline arteries but also in the placenta.…”

Section: Introductionmentioning

confidence: 98%

Definitive human and mouse hematopoiesis originates from the embryonic endothelium: a new class of HSCs based on VE-cadherin expression

Oberlin¹,

Hafny²,

Petit³

et al. 2010

Int. J. Dev. Biol.

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Hematopoietic stem cells (HSCs) arise first in the third week of human ontogeny inside yolk sac developing blood vessels, and independently, from the wall of the embryonic aorta and vitelline arteries one week later. HSCs produced in the yolk sac and in the embryonic truncal arteries migrate to and transiently colonize the embryonic liver (EL), and thereafter the bone marrow (BM), their permanent site of residence. At the moment, the origin of human HSCs is still controversial; one of the main hypotheses being that they are generated by hemogenic endothelial cells (ECs). To proove definitively the endothelial origin of HSCs that arise within the human embryo, we previously purified ECs from either the yolk sac or the truncal arteries and reported that they were able to produce blood cells in vitro. We then found that some of the HSCs present in the human EL were co-expressing vascular endothelial (VE)-cadherin, an endothelial marker, CD45, a pan-hematopoietic marker, and CD34, a common endothelial and hematopoietic marker, and demonstrated that these HSCs bearing a dual hemato-endothelial phenotype were endowed with remarkably high self renewal and proliferative potentials. Furthermore, a transgenic mouse model based on the VE-cadherin cis-regulating elements that we engineered to trace the fate of the first VE-cadherin expressing cells allowed us to clearly demonstrate that a majority of adult BM HSCs derived from a VE-cadherin ancestor. Altogether our studies strongly suggest that at least a part of both the human and the murine hematopoietic systems arise from an endotheliumlike ancestor.

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“…MSCs isolated from placenta showed features comparable to those isolated from bone marrow 14 . These placenta-derived cells seem to be able to differentiate into endothelial cells as well as mesenchymal cells, suggesting the existence of resident endothelial progenitors during embryonic development 34 . Furthermore, it appears that the tissues of the placenta located between the vitelline yolk and aorta are an independent site for the regeneration of CD34+ hematopoietic stem cells 35 , which together with the CD31+ and CD133+ endothelial progenitors, support angiogenesis in the fetus 34 .…”

Section: Placentamentioning

confidence: 99%