RETRACTED: Kidney Function and Rate of Bone Loss at the Hip and Spine: The Canadian Multicentre Osteoporosis Study

Jamal, Sophie A.; Swan, Victoria; Brown, Jacques P.; Hanley, David A.; Prior, Jerilynn C.; Παπαϊωάννου, Αλεξάνδρα; Langsetmo, Lisa; Josse, Robert G.

doi:10.1053/j.ajkd.2009.10.049

Cited by 55 publications

(46 citation statements)

References 28 publications

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“…Some studies have shown that low BMD measurements were more prevalent in patients with CKD like our findings while several other studies have reported no relationship between CKD and low BMD measurements [22][23][24][25]. In our study, except Z score at Ward's triangle, all of the T and Z scores were found statistically significantly lower in CKD patients especially T and Z scores at lumbar 3 and 4 [7,[26][27][28].…”

Section: Discussionsupporting

confidence: 64%

Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels

Peynirci

Ersoy

Gürsoy

et al. 2019

The European Research Journal

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Objectives: Although bone biopsy is considered the gold standard for the definitive diagnosis of renal osteodystrophy; it is not suitable for routine clinical practice due to its invasive nature. The present study was aimed to evaluate and compare the bone mineral status using dual energy X-ray absorptiometry of patients with or without chronic kidney disease in young population with elevated parathyroid hormone levels. Methods: This was a single center, cross-sectional, retrospective study conducted in patients younger than 45 years of age. The study was performed in the outpatient clinic of a university hospital. Patients with elevated parathyroid hormone levels were included. Results: Among them, 29 had renal insufficiency, 158 had normal renal function. Measured bone mineral density with dual energy X-ray absorptiometry and laboratory values were collected from patient files. The primary end point was to assess the efficiacy of dual energy X-ray absorptiometry in patients with or without renal failure. Except Z score at Ward's triangle, all of the T and Z scores at lomber, femur neck, trochanteric, and intertrochanteric areas were found significantly lower in patients with chronic kidney disease compared to those without (p < 0.001). Conclusion: Dual energy X-ray absorptiometry seemed to be a reliable method for detection of osteoporosis in premenopausal female and male patients younger than 45 years of age with or without renal failure with elevated parathyroid hormone levels.

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Section: Discussionsupporting

confidence: 64%

Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels

Peynirci

Ersoy

Gürsoy

et al. 2019

The European Research Journal

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“…Measurements were performed on a QRD 2000 bone densitometer (Hologic Inc.), using dual-energy X-ray absorptiometry (DXA). The results are expressed as T-scores and Z-scores and in absolute values (g/cm 2 ). T-scores and Z-scores reflect the number of standard deviations by which a patient value differs from the sexmatched young adult reference mean or from the sex-and age-matched mean, respectively.…”

Section: Bone Mineral Density Measurementsmentioning

confidence: 99%

“…1 ). Men and women with impaired kidney function are at increased risk of bone loss, even with minimal reduction in kidney function 2 . It is reasonable to assume that many patients with chronic kidney disease (CKD) have other disorders of bone that contribute to the final picture of renal osteodystrophy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of biochemical markers and bone mineral density in patients with chronic kidney disease stage 5D at the start of hemodialysis treatment

Valkovský¹,

R²,

Tvrdík³

et al. 2015

BIOMED PAP

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Background. Patients with chronic kidney disease (CKD) have significant disorders of bone and mineral metabolism. In addition, they can also develop other bone disorders including osteoporosis. This study evaluated the bone mineral density (BMD) of patients at the start of hemodialysis treatment as well as the relationship between BMD and possible risk factors or biochemical markers. Methods. The study was performed in 82 patients (28 females, 54 males). BMD was measured by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and the proximal femur. Results. We found a high prevalence of 25-hydroxyvitamin D deficiency (96%; mean levels 30.0 ± 17.7 nmol/L) and a reduction of BMD in comparison with gender-and age-matched normal population values at the total hip (Z-score = -0.31 ± 1.11) and the femoral neck (Z-score = -0.48 ± 1.16), but not at the lumbar spine (Z-score = 0.68 ± 1.81). The prevalence of T-scores ≤ -2.5 SD in the group of patients over 50 years was 52.0% in females and 33.3% in males. BMD positively correlated: with male gender and calcium levels at all measured sites, with age at the lumbar spine and with weight or BMI at the proximal femur. Conclusion. CKD patients at the start of hemodialysis treatment had a high prevalence of low T-score values, corresponding to values for osteoporosis in the general population. BMD at the proximal femur was below the expected average for age and gender, but at the lumbar spine, BMD in hemodialysis patients was above average in persons without known CKD.

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“…Elevated PTH levels cause an anabolic effect on trabecular bone and catabolic effects on cortical bone and it is progressively increased as kidney function declines (5). Patients with CKD are at increased risk of bone loss, even with minimal reduction in kidney function (7). The effects of the hemodialysis period on BMD and biochemical markers of bone metabolism in developing countries have not been well studied (8).…”

Section: Introductionmentioning

confidence: 99%

Bone mineral density and bone metabolism biochemical markers in patients with chronic kidney disease at the hemodialysis treatment

Tamadon¹,

Moghimi²,

Semnani³

2017

J Parathyr Dis

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Introduction: Chronic kidney disease (CKD) is associated with bone and mineral metabolism disorders. Objectives: This study investigated the bone mineral density (BMD) and bone metabolism biochemical markers in patients with CKD at the hemodialysis treatment among Iranian adults as well as the relationship between possible risk factors or biochemical markers with BMD. Patients and Methods:In this cross-sectional study, 77 patients with CKD stage 5D at the hemodialysis treatment were selected from September 2016 to February 2016. BMD was measured by dual-energy X-ray absorptiometry (DEXA) at the anteroposterior lumbar spine (LS) (L1-L4) and left proximal femur. Biochemical markers including calcium (Ca), phosphorus (P), intact parathyroid hormone (iPTH), serum specific alkaline phosphatase (serum AP) and 25-hydroxy-vitamin D (25hD) were used for the prediction of BMD loss. Results: Two (2.6%) patients had normal levels of 25hD (mean levels 17.67 ± 11.66 µg/L). We found a reduction of BMD in comparison with age-and gender-matched normal population values at the femoral neck (FN) (T-score = -1.92 ± 1.29), at the total hip (TH) (T-score = -1.79 ± 1.25) and at the LS (T-score = -1.55 ± 1.84). The prevalence of T-scores ≤-2.5 SD was 28.6%, 35.1% and 13.0% according to the LS, FN and three bone sites T scores respectively. BMD negatively correlated with age at the proximal femur, with serum AP at the LS and with age of menopause at the FN. Conclusions:Patients with CKD at the hemodialysis treatment had a high prevalence of osteoporosis in the general population. BMD at the all bone sites was below the expected average for gender and age. Keywords: Bone mineral density, Chronic kidney disease, Hemodialysis, Biochemical markers, Osteoporosis Please cite this paper as: Tamadon MR, Moghimi J, Semnani V. Metabolic bone disease in end-stage renal disease patients under regular hemodialysis. J Parathyr Dis. 2018;6(2):50-56.

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RETRACTED: Kidney Function and Rate of Bone Loss at the Hip and Spine: The Canadian Multicentre Osteoporosis Study

Cited by 55 publications

References 28 publications

Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels

Comparison of laboratory and imaging methods associated with bone metabolism in patients with or without renal failure under the age of 45 years with elevated parathyroid hormone levels

Evaluation of biochemical markers and bone mineral density in patients with chronic kidney disease stage 5D at the start of hemodialysis treatment

Bone mineral density and bone metabolism biochemical markers in patients with chronic kidney disease at the hemodialysis treatment

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