RETRACTED ARTICLE: The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis

Farrokhi, Mehrdad; Masoudifar, Aria; Derakhshan, Ali; Saadatmand, Samira; Rouhi-Boroujeni, Hojjat; Etemadifar, Masoud; Rezaei-Zarji, Saeid; Javid, Ameneh; Nobakht, Reza; Deyhimi, Mitra Sadat; Ekramnia, Afagh; Ebrahimi, Milad; Sheikh, Sheema; Ansaripour, Sadra; Amani-Beni, Ali; Jahanbani-Ardakani, Hamidreza

doi:10.1080/08820139.2016.1268154

Cited by 14 publications

(10 citation statements)

References 27 publications

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“…Previous studies have not observed an association between rs4072111 and osteoporosis [40], osteosarcoma [42], endometriosis [34] and Graves' disease [50]. However, this polymorphism was a risk factor for systemic erythematic lupus among Chinese [49] and multiple sclerosis in Iranians [45].…”

Section: Plos Onementioning

confidence: 79%

“…Similar results were found in two previous studies conducted in 2005 and 2018 in an Iranian adult population with PD [ 23 , 24 ]. An association was also not found between this SNP and other diseases, such as asthma [ 43 , 44 ], osteosarcoma [ 42 ], multiple sclerosis [ 45 ], endometriosis [ 46 ] and autoimmune thyroid disease [ 47 ]. On the other hand, this polymorphism was associated with an increased risk for Graves' disease [ 48 ] and systemic lupus erythematosus [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

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Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

et al. 2020

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Periodontitis (PD) is a chronic inflammatory process resulting from the relationship of the immune response with the components in dental plaque. Cytokines and their genetic polymorphisms seem to be involved in the immunopathogenesis of this disease. This study aimed to evaluate the correlation of IL16 polymorphism with PD. A case-control study was conducted in a sample of individuals from southern Brazil. The genotyping of IL16, rs11556218 T>G, rs4072111 C>T e rs4778889 T>C, was performed using the PCR-RFLP methodology. The serum level of IL-16 was determined using an IL-16 ELISA kit for humans. SNPStats and OpenEpi software and Wilcoxon's U test were used to perform statistical analysis. IL16 rs11556218 polymorphism was significantly associated to PD in nonsmoking patients: individuals with G/G genotype were less likely to develop PD compared to the T/T genotype (OR = 0.10; Pc = 0.019, codominant model). In addition, the TTT haplotype was associated with a high risk for PD (OR = 2.45; P = 0.01). A low IL-16 serum level was observed among individuals with PD when compared to controls (P = 0.027). Thus, the IL16 rs16556218 polymorphism and the serum levels of IL-16 were associated with periodontitis in a Brazilian sample, and this was influenced by environmental factors such as smoking.

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Section: Plos Onementioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

et al. 2020

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“…This SNP was previously identified as a marker candidate for aggressive prostate cancer [64], although this was not confirmed for an African American population [46,65]. This polymorphism was also correlated with better prognosis for chronic lymphoid leukemia in an English population [66], associated with the risk of liver cancer [40], colorectal and gastric cancer [67,68], autoimmunity [49,50], endometriosis [51], and knee osteoarthritis [52,53].…”

Section: Discussionmentioning

confidence: 99%

“…in Caucasians [47], diabetes mellitus [48], autoimmune diseases [49,50], endometriosis [45,51], and knee osteoarthritis [52,53]. A meta-analysis published in 2019 focusing only on renal cancer association studies also found no association between rs4778889 and rs11556218 and this disease [54].…”

Section: Discussionmentioning

confidence: 99%

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

et al. 2020

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Introduction: Interleukin-16 (IL-16) is a chemotactic cytokine that is found to increase in Cancer and cardiovascular diseases (CVD). Single nucleotide polymorphisms (SNPs) in IL16 were associated with diseases. Thus, we conducted a systematic review and meta-analysis to evaluate possible associations between IL16 rs4778889, rs11556218, rs4072111, and rs1131445 SNPs and the risk for cancer or CVD. Materials and Methods: This study was performed according to the PRISMA statement. Medline, Web of Science, and Scopus databases were systematically reviewed, and a meta-analysis was conducted. Results: The analysis comprised 6386 individuals with cancer and 2415 with CVD. The SNP rs11556218 was significantly associated with an increased risk for cancer in Chinese in different genetic inheritance models. Also, to the best of our knowledge, this is the first meta-analysis to show an association of rs4778889 with an increased risk of gastric cancer and rs11556218 with an increased risk of CVD in Chinese. Conclusions: Our meta-analysis suggested that the SNPs rs11556218 and rs4778889 of IL16 were associated with an increased risk for cancer in Chinese and rs11556218 with increased risk for CVD in Chinese, highlighting the need for further studies on the impact of these polymorphisms on cancer treatment and surveillance.

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“…So far, many efforts have been conducted to study the genetic architecture of MS in different populations like Iran. 4,[12][13][14][15] http://ijnl.tums.ac.ir 04 April However, these attempts have only been able to identify a small proportion of the causes of disease, highlighting the need to assess non-genetic factors as well as the interplay between environmental and genetic factors. In addition, genetic effect alone does not justify the low MS concordance rate between monozygotic twins.…”

Section: Discussionmentioning

confidence: 99%

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

Yazdanpanahi

Etemadifar

Shams

2019

CJN

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Background: Deoxyribonucleic acid (DNA) methyltransferase 3 beta (DNMT3B) gene encodes an MT enzyme involving in de novo methylation of DNA. The present investigation aimed to explore the association of DNMT3B-579G>T (rs1569686) polymorphism with multiple sclerosis (MS). Methods: 130 Iranian patients with MS and 130 controls were genotyped for the DNMT3B-579G>T using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: There was no statistically significant association between DNMT3B-579G>T and susceptibility to MS. The alleles and genotypes of DNMT3B-579G>T did not have different risks of MS development under various models [T vs. G (P = 0.86); GTvs. GG (P = 0.48); TT vs. GG (P > 0.99); GT+TT vs. GG (P = 0.60), and TT vs. GG+GT (P = 0.87)]. Also, there was no statistically significant association between genotypes and clinical and demographic characteristics of patients (P > 0.05). Conclusion: The current findings suggest that DNMT3B-579G>T is probably not a crucial potential risk marker in molecular diagnostics of MS among Iranian. However, to the best of our knowledge, this is the ﬁrst genetic association study about the DNMT3B polymorphisms and MS. Therefore, further surveys should be included to estimate the exact relevance of DNMT3B gene to the development of autoimmune disorders like MS.

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RETRACTED ARTICLE: The Association of Interleukin-16 Gene Polymorphisms with IL-16 Serum Levels and Risk of Multiple Sclerosis

Cited by 14 publications

References 27 publications

Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

Association of functional IL16 polymorphisms with cancer and cardiovascular disease: a meta-analysis

DNMT3B-579G>T (rs1569686G>T) polymorphism and the risk of multiple sclerosis in a subset of Iranian population

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