Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

Souza, Victor Hugo de; Visentainer, Jeane Eliete Laguila; Zacarias, Joana Maira Valentini; Alencar, Josiane Bazzo de; Tsuneto, Patrícia Yumeko; Silva, Cléverson O.; Salmeron, Samira; Colli, Cristiane Maria; Sell, Ana Maria

doi:10.1371/journal.pone.0239101

Cited by 4 publications

(4 citation statements)

References 48 publications

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“… 19 In the Brazilians population, more rs4072111 CT genotype carriers are detected in individuals with periodontitis than that in the healthy control group. 13 These results are consistent with our findings in patients with PI. It was concluded that the PI susceptibility in patients with rs4072111 T allele may be related to the relationship between this SNP and inflammation.…”

Section: Discussionsupporting

confidence: 93%

“… 19 Notably, IL-16 gene SNPs have been identified to be related to the development of periodontitis in several study populations. 13 , 20 , 21 In the present study, two common SNPs in IL-16 gene, including rs11556218 and rs4072111, were selected, and genotype and allele distribution in PI cases were analyzed in 162 healthy implants and 162 PI cases. The case and control groups were age and gender matched.…”

Section: Discussionmentioning

confidence: 99%

“… 11 , 12 The two SNPs have been reported to be related to the genetic susceptibility of periodontitis. 13 In light of the important role of periodontitis in PI, the genetic correlation between IL-16 gene and PI should be investigated. Therefore, this study was designed to explore the genetic association of IL-16 gene rs11556218 and rs4072111 SNPs with PI at the gene level.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population

Chen¹,

Chen²

2021

PGPM

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Purpose Peri-implantitis (PI) is a major contributor to dental implant failure. Genetic predisposition plays an essential role in the development of PI. The purpose of this study was to investigate the correlation of IL-16 gene single nucleotide polymorphisms (SNPs), rs11556218 and rs4072111, with PI at the gene level. Patients and Methods A total of 162 patients with PI and 162 cases with healthy implants were recruited as the case and control groups, respectively. The genotypes were analysed using direct sequencing. The genotype and allele proportion between the case and control groups were compared using the chi-square test. The periodontal status of patients carrying different genotypes was analysed, including gingival index, plaque index, calculus index, peri-implant pocket depth (PPD), and clinical attachment level (CAL). Results The case and control groups were age- and gender-matched. In the case group, the rs4072111 CT genotype was majorly observed, and the T allele carriers showed a high PI risk. Patients with the rs4072111 CT genotype had worse periodontal status, which was reflected by the higher levels of the gingival index, plaque index, calculus index, PPD and CAL. The distribution of the rs11556218 genotype and T allele showed no significant difference between the case and control groups ( P > 0.05). Conclusion The CT genotype of IL-16 gene rs4072111 SNP can be used as a factor assessing PI risk. Therefore, IL-16 genetic variation may be related to PI susceptibility in the Chinese Han population.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population

Chen¹,

Chen²

2021

PGPM

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“…Genetic variations in the DEFB1 gene could affect gene expression and increase the susceptibility to periodontitis by having reduced capability to attack the pathogens, hence leading to the disease. Several polymorphism studies in periodontitis including matrix metalloproteinase 3 [ 10 ], interleukin 16 (IL-16) [ 11 ], IL1α [ 12 ], and tumor necrosis factor α (TNFα) [ 13 ] have been carried out. Our study analyzed the effect of genetic variations in 5’ UTR (rs11362 (-20G>A), rs1800972 (-44C>G), and rs1799946 (-52G>A)) of the DEFB1 gene on the susceptibility to periodontitis associated with T2DM in the south Indian population and their influence on gene expression.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphism and Gene Expression of β-Defensin-1 in Periodontitis Associated With Type 2 Diabetes Mellitus

Venkata Subbiah,

Ramesh Babu,

Subbiah

2023

Cureus

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Introduction Periodontitis is a multifactorial disease caused by periodontopathic bacteria and influenced by both genetic and environmental factors. Genetic predispositions are found to play a crucial part in the onset and progression of periodontal disease. There is a two-way relationship between diabetes and periodontitis with severe periodontal tissue destruction seen in diabetic patients. Antimicrobial peptide, β-defensin-1 ( DEFB1 gene), plays an important role in the innate immune responses and forms the first line of host defense against periodontal pathogens. Single nucleotide polymorphisms (SNPs) in the specific genetic loci of the DEFB1 gene and its expression level could confer a degree of risk or protection from periodontitis associated with diabetes. The present study determined the association between SNPs at the 5’ untranslated region (UTR) in the DEFB1 gene and susceptibility to periodontitis associated with type 2 diabetes mellitus (T2DM) and analyzed the effect of 5’ UTR polymorphisms on DEFB1 gene expression . Methods SNPs in the 5’ UTR of the DEFB1 gene (-20G>A (rs11362), -44C>G (rs1800972), and -52G>A (rs1799946)) were genotyped by polymerase chain reaction (PCR) followed by Sanger sequencing. The study group included periodontitis (n = 40), periodontitis with T2DM (n = 20), and periodontally and systemically healthy as controls (n = 40). DEFB1 gene expression was determined by real-time PCR in the study group comprising periodontitis (n = 20), periodontitis with T2DM (n = 15), and healthy controls (n = 20). The effect of 5’ UTR polymorphisms on the expression was analyzed by statistical tools. Results Statistically significant higher prevalence of the variant AA genotype of rs11362 was observed in periodontitis (odds ratio (OR) = 3.64, 95% confidence Interval (CI) = 1.16-11.43, p = 0.04) and periodontitis with T2DM (OR = 5.14, 95% CI = 1.29-20.5, p = 0.03) in comparison with healthy controls. Moreover, there was a significant increase of the variant AA genotype of rs1799946 in periodontitis (OR = 3.88, 95% CI = 1.19-12.68, p = 0.04) compared to healthy controls. DEFB1 gene expression was downregulated in periodontitis and upregulated in periodontitis with T2DM patients when compared to healthy controls but was not statistically significant. No significant association was found for the effect of SNPs of the DEFB1 gene on its expression. Conclusion From the SNP analysis, it can be inferred that the presence of SNPs at the 5’ UTR (rs11362 and rs1799946) in the DEFB1 gene may be an important predictive factor for periodontitis.

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Clinical diagnostic value of IL-14, 1L-16 and SAA in periodontitis

Lu,

Li,

et al. 2023

Clin Oral Invest

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Association of IL16 polymorphisms with periodontitis in Brazilians: A case- control study

Cited by 4 publications

References 48 publications

Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population

Interleukin-16 rs4072111 Polymorphism is Associated with the Risk of Peri-Implantitis in the Chinese Population

Genetic Polymorphism and Gene Expression of β-Defensin-1 in Periodontitis Associated With Type 2 Diabetes Mellitus

Clinical diagnostic value of IL-14, 1L-16 and SAA in periodontitis

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