RETRACTED ARTICLE: Mesenchymal stem cells-derived exosomal microRNA-139-5p restrains tumorigenesis in bladder cancer by targeting PRC1

Jia, Yuefeng; Ding, Xuemei; Zhou, Lihua; Zhang, Li; Yang, Xuecheng

doi:10.1038/s41388-020-01486-7

Cited by 73 publications

(40 citation statements)

References 34 publications

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“…It directly targets and downregulates the expression of UbiA prenyltransferase domain-containing protein 1 (UBIAD1), and then stimulating BCa cell proliferation ( 53 ). Conversely, miR-139-5p and miR-133b are downregulated in serum exosomes and inhibited the BCa cell multiplication ( 54 , 55 ).…”

Section: The Biological Roles Of Exosome-derived Ncrnas In Bcamentioning

confidence: 99%

“…revealed that miR-29c induced the apoptosis of bladder cancer BIU-87 cells by downregulating two well-known antiapoptotic genes, BCL-2 and MCL-1 ( 81 ). Exosomal miR-139-5p and miR-375-3p also expedited cell apoptosis by targeting PRC1 and FZD8, respectively ( 54 , 65 ). In addition to miRNAs, exosomal lncRNA PTENP1 accelerates the bladder cancer EJ and J82 cell apoptosis ( 82 ).…”

Section: The Biological Roles Of Exosome-derived Ncrnas In Bcamentioning

confidence: 99%

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Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

et al. 2021

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Bladder cancer (BCa) is a common heterogeneous urinary system tumor with high malignancy and limited advancement in treatment. Limited understanding of BCa has not contributed to any significant progress in diagnosis or treatment, exploring the mechanisms underlying BCa has become an urgent research focus. Exosomes, a type of extracellular vesicle (EV), have drawn substantial interest for their important roles in mediating intracellular communication. Exosomes shuttle numerous bioactive molecules, and noncoding RNAs (ncRNAs) are among the most numerous. ncRNAs including microRNA, long noncoding RNA, and circular RNA are sorted and packaged into exosomes selectively and transferred into recipient cells to regulate their function. Exosomal ncRNAs are associated with hallmarks of BCa, such as proliferation, apoptosis, epithelial-mesenchymal transition (EMT), cell cycle arrest, lymphangiogenesis, and chemotherapy resistance. Exosomal ncRNAs can also be detected in urine and serum, making them encouraging biomarkers for BCa diagnosis and prognosis. More importantly, exosomes exhibit excellent biocompatibility and potential for diversified applications. The delivery of bioactive substances and drugs into specific cells has become a promising approach for precision therapy for BCa patients. In addition, cancer vaccines have also received increasing attention. In this review, we summarize the current research on the regulatory roles of exosomal ncRNAs in BCa tumorigenesis and progression, as well as their potential clinical value in accelerating the diagnosis and therapy of BCa.

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Section: The Biological Roles Of Exosome-derived Ncrnas In Bcamentioning

confidence: 99%

Section: The Biological Roles Of Exosome-derived Ncrnas In Bcamentioning

confidence: 99%

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

et al. 2021

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“…miR-139-5p is down-regulated in bladder cancer, and acts by reducing the expression of the polycomb repressor complex 1 (PRC1) gene. It was demonstrated that upon exosomal miR-139-5p transfer into bladder cancer cells, cell proliferation, migration and invasion potentials were inhibited [255]. The same effect was evidenced by transfecting miR-381 loaded on exosomes isolated from adipose tissue-derived mesenchymal stem cells into TNBC cells.…”

Section: Potential Role Of Exosomes In Cancer Treatmentmentioning

confidence: 81%

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

et al. 2021

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Exosomes are extracellular vesicles released by cells, both constitutively and after cell activation, and are present in different types of biological fluid. Exosomes are involved in the pathogenesis of diseases, such as cancer, neurodegenerative diseases, pregnancy disorders and cardiovascular diseases, and have emerged as potential non-invasive biomarkers for the detection, prognosis and therapeutics of a myriad of diseases. In this review, we describe recent advances related to the regulatory mechanisms of exosome biogenesis, release and molecular composition, as well as their role in health and disease, and their potential use as disease biomarkers and therapeutic targets. In addition, the advantages and disadvantages of their main isolation methods, characterization and cargo analysis, as well as the experimental methods used for exosome-mediated drug delivery, are discussed. Finally, we present potential perspectives for the use of exosomes in future clinical practice.

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“…Fu et al [53] extracted BM-MSC-EXs for an miR-19b-1-5p inhibition and elevation test and found that BM-MSC-derived exosomal miR-19b-1-5p could inhibit the growth of bladder cancer by downregulating nonreceptor protein tyrosine kinase Arg (ABL2). Similarly, Jia et al [54] found that hUC-MSCderived exosomal miR-139-5p could inhibit the progression of bladder cancer through targeting and downregulating PRC1.…”

Section: Effects On Bladder Cancermentioning

confidence: 91%

Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy

Sun

Zhang

et al. 2021

Stem Cells International

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Exosomes have emerged as a new drug delivery system. In particular, exosomes derived from mesenchymal stem cells (MSCs) have been extensively studied because of their tumor-homing ability and yield advantages. Considering that MSC-derived exosomes are a double-edged sword in the development, metastasis, and invasion of tumors, engineered exosomes have broad potential use. In this review, we focused on the latest development in the treatment of tumors using engineered and nonengineered MSC-derived exosomes (MSC-EXs). Nonengineered MSC-EXs exert an antitumor effect on several well-studied tumors by affecting tumor growth, angiogenesis, metastasis, and invasion. Furthermore, engineered exosomes have promising research prospects as drug-carrying tools for the transport of miRNAs, small-molecule drugs, and proteins. Although exosomes lack uniform standards in terms of definition, separation, and purification, they still have great research value because of their unique advantages, such as high biocompatibility and low toxicity. Future studies on MSC-EXs should elucidate the mechanisms underlying their anticancer effect and the safety of their application.

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RETRACTED ARTICLE: Mesenchymal stem cells-derived exosomal microRNA-139-5p restrains tumorigenesis in bladder cancer by targeting PRC1

Cited by 73 publications

References 34 publications

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

Biological Roles and Clinical Significance of Exosome-Derived Noncoding RNAs in Bladder Cancer

Exosomes: Potential Disease Biomarkers and New Therapeutic Targets

Roles of Mesenchymal Stem Cell-Derived Exosomes in Cancer Development and Targeted Therapy

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