Retinopathy of prematurity in Indonesia: Incidence and risk factors

Siswanto, Johanes Edy; Sauer, Pieter

doi:10.3233/npm-915142

Cited by 27 publications

(24 citation statements)

References 20 publications

(25 reference statements)

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“…[ 16 17 ] A study conducted in Indonesia concluded a similar prevalence. [ 18 ] A study conducted in Kenya[ 19 ] showed that the majority of retinopathy were Stage 1 and 2 and are similar to the current findings. However, in our study, We are surprising to observe that, despite many cases of visionthreatening retinopathy of prematurity (ROP stages that require intervention), only 8.3% received interventional treatment by referral them to higher centers in the big cities in KSA, this may can be explained by that, many families seeking treatment at near countries like Jordan which is closer than travel to referred center in KSA.…”

Section: Discussionsupporting

confidence: 87%

Incidence and risk factors for retinopathy of prematurity in Tabuk city, KSA

ALBalawi

Albalawi

Alsuhaimi

et al. 2020

Middle East Afr J Ophthalmol

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PURPOSE: Retinopathy of prematurity (ROP) is becoming a leading cause of preventable blindness. The current study aimed to assess ROP and its risk factors in Tabuk City, Northern Kingdom of Saudi Arabia. METHODS: A retrospective study was conducted in King Khalid Hospital, Tabuk City, Saudi Arabia. The premature infants' records during the period of January 2016 to April 2018 were approached. One hundred and eight records were eligible; the infants' gestational age, weight, if received oxygen, surfactant use, blood transfusion, intraventricular hemorrhage, and patent ductus arteriosus were reported. Chi-square test was used to compare premature infants and their counterparts regarding various risk factors. P < 0.05 was considered statistically significant. RESULTS: Out of 108 premature infants, 33.3% had ROP (Many were sightthreatening [stages required treatment] and more than twothirds involving both eyes); a statistically significant difference ( P < 0.05) was evident between infants with prematurity, and low birth weight. No significant differences were found regarding other risk factors ( P > 0.05). Only 8.3% received interventional therapy. CONCLUSION: ROP is common in King Khalid Hospital, which is the referral tertiary hospital in Tabuk city, KSA . The low birth weight is a significant risk factor to develop ROP. Many of ROP cases were sightthreatening (cases that required treatment) and most cases involving both eyes. Treatment availability at Tabuk city is recommended, instead of referral to another centers especially among those with low weight at birth.

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Section: Discussionsupporting

confidence: 87%

Incidence and risk factors for retinopathy of prematurity in Tabuk city, KSA

ALBalawi

Albalawi

Alsuhaimi

et al. 2020

Middle East Afr J Ophthalmol

View full text Add to dashboard Cite

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“…In contrast, an incidence is seen in infants born before 26 weeks 1 2. We showed that the incidence of ROP is higher in preterm infants born in Indonesia as compared with developed countries, and is also seen in infants with gestational ages of up to 34 weeks 3. Our results are in accordance with other studies in low-income and middle-income countries 4…”

Section: Introductionsupporting

confidence: 91%

“…Gestational age, birth weight and use of supplemental oxygen are known risk factors. In Indonesia, we found that other factors such as sepsis, asphyxia, patent ductus arteriosus and multiple blood transfusions might also play a role 3. However, none of the presently identified risk factors can explain why some infants develop ROP while others do not.…”

Section: Introductionmentioning

confidence: 92%

Norrie disease gene polymorphism in Indonesian infants with retinopathy of prematurity

et al. 2019

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ObjectiveRetinopathy of prematurity (ROP) is a major cause of blindness in newborn infants, which also occurs in low-income and middle-income countries. Why ROP progresses in some infants while it regresses in others is still presently unknown. Studies suggest that genetic factors might be involved. Mutations in the Norrie disease (ND) gene are suspected to be related to advanced ROP development. Indonesia is a country with relatively high incidence of ROP, yet the role of these genetic factors in the pathogenesis of ROP cases is still unknown. The study aimed to investigate the presence of mutations in ND on the X chromosome in infants with both non-advanced and advanced ROP in Indonesia.Methods and AnalysisThis is a case–control study of polymorphisms in six variants within the ND gene in exon 3, C597A, L108P, R121W, A105T, V60E and C110G, in preterm newborn infants in four major hospitals in Greater Jakarta, Indonesia.ResultsWe included 162 preterm newborn infants. ROP was diagnosed in 83 infants, and 79 infants served as controls. Among those with ROP, 57 infants had type 2, while others had type 1. We did not find any gene polymorphisms in any of the infants with ROP nor in the control group.ConclusionWe conclude that it is very unlikely that the six polymorphisms in exon 3 of the ND gene studied in this paper are involved in the development or progression of ROP in preterm infants in our population sample in Indonesia.

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“…Globally, an estimated third of surviving children with ROP requiring treatment (20.000; 95% CI 15.500 to 27.200) are severely visually impaired or blind secondary to ROP. One paper indicaties that ROP contributed to 1.1% of all cases of blindness in children in Indonesia (Siswanto and Sauer, 2017).…”

Section: Introductionmentioning

confidence: 99%

Case Report: Low Vision Management in A 5-Years-Old Due to Retinopathy of Prematurity for Life Quality Improvement

Aritonang¹

2020

FMI

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Management of low vision in pediatric patients with greater result can affect their quality of life than in adult low vision patients. Retinopathy of prematurity is the main cause of blindness in children. A case study highlights the tertiary prevention (low vision examination and management) in a 5 year old boy with ROP related blindness to optimize his remaining visual capacity by using optical and non-optical aids that support daily activity and educational learning. A 5-year-old boy with ROP related blindness visited to the low vision clinic after receiving the several treatments for ROP before. His visual acuities were light perception in the right eye and hand movement in the left eye using his current spectacle correction. He had anti VEGF bevacizumab intravitreal injection, vitrectomy and complicated cataract extraction history on the left eye. He was difficult to learn and read numbers and alphabets caused by visual impairment. Upon evaluation by assessment low vision method, his distance visual acuity in the left eye was improved significantly up to 3/40 on LEA Acuity chart with +14.00D. His near vision became 10 M at 30 cm of reading distance (without near correction) and 4 M at 13 cm improved with +3.00 D by spectacle. The non-optical aid devices as reading task were also suggested to improve continuous reading text without difficulty. ROP blindness can be preventable if appropriate, adequate and accessible screening programmes are available. Unfortunately, even with the current screening guidelines and recommended treatment of ROP, many babies suffer from blindness by this disease each year. Low vision assessment and management in pediatric patient with visual impairment according to children need can optimize the recent visual capability of low vision patient and give selfcare daily activity and educational learning.

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Retinopathy of prematurity in Indonesia: Incidence and risk factors

Cited by 27 publications

References 20 publications

Incidence and risk factors for retinopathy of prematurity in Tabuk city, KSA

Incidence and risk factors for retinopathy of prematurity in Tabuk city, KSA

Norrie disease gene polymorphism in Indonesian infants with retinopathy of prematurity

Case Report: Low Vision Management in A 5-Years-Old Due to Retinopathy of Prematurity for Life Quality Improvement

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