Norrie disease gene polymorphism in Indonesian infants with retinopathy of prematurity

Abstract

ObjectiveRetinopathy of prematurity (ROP) is a major cause of blindness in newborn infants, which also occurs in low-income and middle-income countries. Why ROP progresses in some infants while it regresses in others is still presently unknown. Studies suggest that genetic factors might be involved. Mutations in the Norrie disease (ND) gene are suspected to be related to advanced ROP development. Indonesia is a country with relatively high incidence of ROP, yet the role of these genetic factors in the pathogenesis of ROP cases is still unknown. The study aimed to investigate the presence of mutations in ND on the X chromosome in infants with both non-advanced and advanced ROP in Indonesia.Methods and AnalysisThis is a case–control study of polymorphisms in six variants within the ND gene in exon 3, C597A, L108P, R121W, A105T, V60E and C110G, in preterm newborn infants in four major hospitals in Greater Jakarta, Indonesia.ResultsWe included 162 preterm newborn infants. ROP was diagnosed in 83 infants, and 79 infants served as controls. Among those with ROP, 57 infants had type 2, while others had type 1. We did not find any gene polymorphisms in any of the infants with ROP nor in the control group.ConclusionWe conclude that it is very unlikely that the six polymorphisms in exon 3 of the ND gene studied in this paper are involved in the development or progression of ROP in preterm infants in our population sample in Indonesia.

Exploration of Hub Genes in Retinopathy of Prematurity Based on Bioinformatics Analysis of the Oxygen-Induced Retinopathy Model

“…Recently, some studies have used microarray data profiles to illustrate the pathogenesis of ROP [9][10][11][12][13][14], but these studies were based on only a single cohort or single genetic event. To overcome this inadequacy, a comprehensive combination of gene expression profiling techniques and integrative bioinformatics approaches should be performed.…”

The Genetics and Clinical Variables of Retinopathy of Prematurity: A Matched Case Control Study

“…[2] In addition, the incidence of ROP is different in different races. [3] This suggested that various changes in the nuclear coding genes might be involved in the occurrence and development of ROP. [2] Familial exudative vitreoretinopathy (FEVR) is an inherited vitreoretinopathy, with clinical manifestations similar to ROP, [4] involving several genes with different variations, including insertions, point mutations, or deletions, which include Frizzled-4 (FZD4), lipoprotein receptor-related protein 5 (LRP5), Norrie disease protein (NDP), and tetraspanin-12 (TSPAN12).…”