Retinol-binding protein 4 and insulin resistance are related to body fat in primary and secondary schoolchildren: the Ouro Preto study

Abstract

IR(HOMA) and RBP4 showed significant associations with obesity and traditional CVD risk factors. They might therefore be used as a marker for CVD risk and have clinical implications in the development of comorbidities associated with obesity.

Association of retinol-binding protein 4 with metabolic syndrome in first-degree relatives of type 2 diabetic patients

“…[25] A previous study revealed a correlation of RBP4 with WHR, suggesting an association between RBP4 levels and abdominal adiposity. [26] In our study, there was correlation between RBP4 levels and hip circumferences. Data demonstrate that changes in adipocyte-derived RBP4 may have systemic effects on insulin sensitivity and glucose homeostasis.…”

“…argued that adipose tissue might be a less important source of circulating RBP4 in humans than in animals and that it was possible that the increase in circulating RBP4 in the IR state was not explained by increased RBP4 production in adipose tissue. [2630] Thus, prospective and biological studies are needed to future explore the association of serum RBP4 with obesity. In line with some studies, we found an association between serum RBP4 and TG.…”

Effects of insulin resistance on the association between the circulating retinol-binding protein 4 level and clustering of pediatric cardiometabolic risk factors

“…In this investigation, we detected a significant modifying effect of HOMA‐IR on the positive linear relationships of serum RBP4 levels with WC and the number of abnormal MetS components. Analogous interaction between RBP4 and HOMA‐IR on obesity was demonstrated in a nested case‐control study conducted in Brazilian school children . IR is a clinical condition that can increase an individual’s vulnerability to developing cardiometabolic disorders .…”

“…Analogous interaction between RBP4 and HOMA-IR on obesity was demonstrated in a nested case-control study conducted in Brazilian school children. 45 IR is a clinical condition that can increase an individual's vulnerability to developing cardiometabolic disorders. 15 These findings indicate that adolescents with high RBP4…”