Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren

Filgueiras, Mariana De Santis; Pessoa, Milene Cristine; Bressan, Josefina; Albuquerque, Fernanda Martins de; Suhett, Lara Gomes; Silva, Mariane Alves; Novaes, Juliana Farias de

doi:10.1007/s00431-021-04040-z

Cited by 6 publications

(5 citation statements)

References 56 publications

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“…Despite differences in obesity in pediatric and adult patients, similar trends in chemerin levels were observed in most studies [32]. Most studies conducted in children have found higher levels of the molecule in overweight/obese individuals than in lean children [33][34][35][36][37][38][39], and only one report found no differences in chemerin levels between children with overweight/obesity and normal BMI [40]. In patients with atrophy of adipose tissue in the course of anorexia nervosa, the concentration of chemerin was lower than in the group of obese and healthy peers [41].…”

Section: Chemerin and Obesitysupporting

confidence: 58%

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Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

2022

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Adipose tissue is the main source of adipokines and therefore serves not only as a storage organ, but also has an endocrine effect. Chemerin, produced mainly in adipocytes and liver, is a natural ligand for chemokine-like receptor 1 (CMKLR1), G-protein-coupled receptor 1 (GPR1) and C-C motif chemokine receptor-like 2 (CCRL2), which have been identified in many tissues and organs. The role of this protein is an active area of research, and recent analyses suggest that chemerin contributes to angiogenesis, adipogenesis, glucose homeostasis and energy metabolism. Many studies confirm that this molecule is associated with obesity in both children and adults. We conducted a systematic review of data from published studies evaluating chemerin in children with various disease entities. We searched PubMed to identify eligible studies published prior to February 2022. A total of 36 studies were selected for analysis after a detailed investigation, which was intended to leave only the research studies. Moreover, chemerin seems to play an important role in the development of cardiovascular and digestive diseases. The purpose of this review was to describe the latest advances in knowledge of the role of chemerin in the pathogenesis of various diseases from studies in pediatric patients. The mechanisms underlying the function of chemerin in various diseases in children are still being investigated, and growing evidence suggests that this adipokine may be a potential prognostic biomarker for a wide range of diseases.

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Section: Chemerin and Obesitysupporting

confidence: 58%

“…There have been conflicting results regarding the link between chemerin and glucose. In one study, chemerin was negatively associated with fasting glucose [40], while in another, the correlation between two substances was assessed as positive. Chemerin may be useful to monitor adolescents with type 1 diabetes mellitus (T1DM).…”

Section: Chemerin and Obesitymentioning

confidence: 99%

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

2022

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“…There is no evidence of mediating role of mother’s BMI on a child’s inflammatory markers; however, it is known that obesity is the main mediator between food consumption and low-grade inflammation ( 44 ) . From the knowledge about the association between adipokines and cardiometabolic outcomes, such as insulin resistance markers and blood pressure ( 45 ) , it is necessary to assess the relationship between the environment and markers beyond the traditional body adiposity measures. Evidence has shown associations of the obesogenic environment with the child’s BMI ( 43 ) , an easy-to-use and low-cost measure.…”

Section: Discussionmentioning

confidence: 99%

Obesogenic neighborhood environment is associated with body fat and low-grade inflammation in Brazilian children: could the mother’s BMI be a mediating factor?

Filgueiras,

Pessoa,

Bressan

et al. 2023

Public Health Nutr.

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Objective: To evaluate the direct and indirect effects of obesogenic and leptogenic neighborhood environments on body fat, and pro- and anti-inflammatory adipokines in Brazilian children. Design: Cross-sectional study. The body fat distribution was assessed using dual-energy X-ray absorptiometry (DXA). Concentrations of leptin and adiponectin were measured. Four hundred meters (0.25 miles) road network buffer was the neighborhood unit used to assess the environmental characteristics around households. Obesogenic and leptogenic environments were the latent variables obtained from the observed characteristics. The mother’s body mass index (BMI), ultra-processed food consumption, and physical activity before and after school, were tested as mediating variables. A hybrid model of structural equations was used to test the direct and indirect effects of obesogenic and leptogenic environments on body fat and leptin and adiponectin concentrations. Setting: Urban area of Viçosa, Minas Gerais, Brazil Participants: Children aged 8- and 9-years (n=367). Results: Obesogenic environment directly affected the mother’s BMI (β: 0.24, P=0.02) and the child’s body fat (β: 0.19, P=0.02). The mother’s BMI and body fat mediated the effect of the obesogenic environment on leptin concentrations (β: 0.05, P=0.02). Conclusions: Obesogenic neighborhood environment directly affects body fat and indirectly affects leptin concentrations in Brazilian children, mediated by the mother’s BMI and body fat.

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“…Obesity is characterised by accumulation of adipose tissue, which is associated with adipokine concentrations, such as the higher leptin, retinol-binding protein 4 (RBP4) and chemerin (pro-inflammatory adipokines), and lower adiponectin (anti-inflammatory adipokine) ( 1 ) . It is known that leptin and adiponectin are positively and inversely associated, respectively, with diastolic blood pressure and homoeostasis assessment model of insulin resistance ( 2 ) . In addition, RBP4 and chemerin have been positively associated with total cholesterol and fasting blood glucose, respectively, demonstrating that adipokines may be important in the phenotyping of childhood obesity ( 2 ) .…”

mentioning

confidence: 99%

“…It is known that leptin and adiponectin are positively and inversely associated, respectively, with diastolic blood pressure and homoeostasis assessment model of insulin resistance ( 2 ) . In addition, RBP4 and chemerin have been positively associated with total cholesterol and fasting blood glucose, respectively, demonstrating that adipokines may be important in the phenotyping of childhood obesity ( 2 ) .…”

mentioning

confidence: 99%

Characteristics of the obesogenic environment around schools are associated with body fat and low-grade inflammation in Brazilian children

Filgueiras

Pessoa

Bressan

et al. 2023

Public Health Nutr.

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Objective: To assess the association of obesogenic environmental characteristics around schools with body adiposity and adipokine concentrations in Brazilian children. Design: Cross-sectional study. Body adiposity was assessed using the dual-energy X-ray absorptiometry (DXA). Concentrations of leptin, adiponectin, retinol-binding protein 4 (RBP4), and chemerin were measured. Predominantly ultra-processed food (UPF) stores, public physical activity (PA) facilities, green spaces, walkability, traffic accidents, and crime were evaluated. The neighborhood unit was the 400 m (0.25 miles) road network buffer around schools. The association of environmental characteristics with body adiposity and adipokine concentrations was assessed by linear regression models using Generalize Estimating Equations (GEE). Setting: Urban schools (n=24), Viçosa, Minas Gerais, Brazil. Participants: Children aged 8 and 9 years (n=378). Results: A higher density of predominantly UPF stores and a lower percentage of green space were associated with higher total (β: 0.12; 95%CI: 0.06, 0.18; and β: -0.10; 95%CI: -0.16, -0.04, respectively) and android body fat (β: 0.28; 95%CI: 0.13, 0.43 and β: -0.18; 95%CI: -0.32, -0.04, respectively). In addition, the densities of PA facilities and crime were inversely associated with leptin concentrations. Traffic accidents density and percentage of green spaces around schools had, respectively, a positive and an inverse association with concentrations of adiponectin and RBP4. Conclusions: Obesogenic environmental characteristics around schools were associated with total and android body fat, as well as with pro-inflammatory adipokine concentrations in Brazilian children from a medium-sized city.

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Pro- and anti-inflammatory adipokines are associated with cardiometabolic risk markers in Brazilian schoolchildren

Cited by 6 publications

References 56 publications

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

Obesogenic neighborhood environment is associated with body fat and low-grade inflammation in Brazilian children: could the mother’s BMI be a mediating factor?

Characteristics of the obesogenic environment around schools are associated with body fat and low-grade inflammation in Brazilian children

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