Retinoic acid dampens LPS-induced NF-κB activity: results from human monoblasts and in vivo imaging of NF-κB reporter mice

All- trans -retinoic acid represses chemokine expression in adipocytes and adipose tissue by inhibiting NF-κB signaling

“…Similar inhibition of NF-κB signaling has already been reported in various cell models [39], and in 348 transgenic NF-κB reporter mice [40]. To pursue the identification of the precise molecular mechanisms, we …”

All-trans-retinoic Acid Reduces BACE1 Expression under Inflammatory Conditions via Modulation of Nuclear Factor κB (NFκB) Signaling

“…It remains to be clarified which RARs are involved in mediating RA's inhibition of LPS-induced NFB activity in our models of neuroinflammation. Further studies from the Bromhoff laboratory (57) showed that atRA repressed LPS-induced whole-body luminescence.…”

9-cis Retinoic Acid Inhibits Inflammatory Responses of Adherent Monocytes and Increases Their Ability to Induce Classical Monocyte Migration

“…Our data clearly show that 9cisRA has a significant inhibitory effect on the production of TNF ␣ and other central proinflammatory cytokines and chemokines in adherent monocytes, a regulation occurring at the transcriptional level. It has previously been reported that 9cisRA changes the inflammatory mediator release of the human monocyte cell line U937 [16] , primary mouse microglia, astrocytes and splenic macrophages [15,17] , as well as murine myelin basic protein-specific T cells [27] . We also found that 9cisRA inhibits IL-10 production, but that the IL-10 level produced by the adherent monocytes in response to LPS after 6 h is low (20-30 pg/ml).…”

“…In addition, RXR may function as a homodimer [7,13,14] . In studies examining the role of 9cisRA in the modulation of inflammation, it is reported that 9cisRA induces the suppression of inflammatory responses in mouse microglia and astrocytes, mouse splenic macrophages and in the human cell line U937 [15][16][17] .…”