Background: BACE1 is the rate-limiting enzyme in the cleavage of amyloid precursor protein to A peptides. Results: Retinoic acid blocks the BACE1 gene up-regulation during inflammation via the inhibition of NFB. Conclusion: Retinoic acid suppresses aspects of neuroinflammation in rodent models of Alzheimer disease including elevated BACE1 transcription. Significance: Retinoids may have an important role in limiting progression of Alzheimer disease.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.