Retinal Sensitivity Loss and Structural Disturbance in Areas of Capillary Nonperfusion of Eyes with Diabetic Retinopathy

Unoki, Noriyuki; Nishijima, Kazuaki; Sakamoto, Atsushi; Kita, Mihori; Watanabe, Dai; Hangai, Masanori; Kimura, Tomio; Kawagoe, Naoaki; Ohta, M.; Yoshimura, Nagahisa

doi:10.1016/j.ajo.2007.07.011

Cited by 67 publications

(51 citation statements)

References 25 publications

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“…5 Since then, numerous studies have demonstrated a link between the presence of DMI and the loss of visual function. 3,[7][8][9][10] Furthermore, other studies suggest that, in patients receiving treatment for diabetic macular edema (DME), the coexistence of DMI may have an adverse effect on outcomes, or limit the benefits of treatments, regardless of whether the treatment consists of laser photocoagulation or intravitreal pharmacotherapies. 2,11,12 Although the deleterious effects of DMI-both from clinical studies, and from the weight of experience in clinical practice-are well established, much remains uncertain.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Macular Ischemia on Visual Acuity in Diabetic Retinopathy

Sim

Keane

Zarranz‐Ventura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

147

140

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PURPOSE.To investigate the impact of diabetic macular ischemia (DMI) on visual acuity (VA), through the analysis of novel fluorescein angiography (FA) parameters.METHODS. Data were retrospectively collected over a 6-month period. DMI severity was graded using Early Treatment Diabetic Retinopathy Study (ETDRS) protocols. Custom software was used to quantify areas of the foveal avascular zone (FAZ), and of capillary nonperfusion over the papillomacular nerve fiber layer bundle, and temporal macula, and associations tested with VA. RESULTS.A total of 488 patients with type 2 diabetes mellitus and FAs of sufficient quality to allow detailed quantitative analyses were included. ETDRS-DMI severity was graded as: none, 39.7%; questionable, 18.4%; mild, 25.2%; moderate, 11.0%; and severe, 5.6%. Median FAZ areas were 0.19 mm CONCLUSIONS. Diabetic macular ischemia is associated with reduced VA in eyes with moderate to severe ETDRS-DMI grades of ischemia but preserved in milder grades. In addition, we describe the independent association of papillomacular nerve fiber bundle ischemia with reduced VA. (Invest Ophthalmol Vis Sci.

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Section: Resultsmentioning

confidence: 99%

The Effects of Macular Ischemia on Visual Acuity in Diabetic Retinopathy

Sim

Keane

Zarranz‐Ventura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

147

140

View full text Add to dashboard Cite

show abstract

“…Of the 69 eyes, 21 were excluded based on the following exclusion criteria: absence of thirdgeneration OCT examination postoperatively, development of neovascular glaucoma postoperatively, and follow-up for less than 6 months postoperatively. The cases with avascular area within 2 disc diameters from the fovea were also excluded, because avascular area could influence the retinal sensitivity and VA [17]. Of the remaining 48 eyes, 37 (77%) which had a final macular thickness of less than 250 µm were included in this study.…”

Section: Methodsmentioning

confidence: 99%

Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy

Sakamoto

Nishijima

Kita

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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133

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“…The optical density of the photoreceptor components might sometimes increase in nonperfused areas, possibly leading to blocked autofluorescence and concomitant hypoautofluorescence. 25,26 Another explanation might be changes in the origin of the fluorophores. Extravasated blood components from the retinal vasculature might affect the metabolism of the photoreceptor cells and concomitant changes in the fluorophores in these cells or reduce turnover of their outer segments, which could lead to decreased accumulation of lipofuscin.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Yoshitake

Murakami

Uji

et al. 2015

Eye

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Purpose To quantify the signal intensity of fundus autofluorescence (FAF) and evaluate its association with visual function and optical coherence tomography (OCT) findings in diabetic macular oedema (DMO). Methods We reviewed 103 eyes of 78 patients with DMO and 30 eyes of 22 patients without DMO. FAF images were acquired using Heidelberg Retina Angiograph 2, and the signal levels of FAF in the individual subfields of the Early Treatment Diabetic Retinopathy Study grid were measured. We evaluated the association between quantified FAF and the logMAR VA and OCT findings. Results One hundred and three eyes with DMO had lower FAF signal intensity levels in the parafoveal subfields compared with 30 eyes without DMO. The autofluorescence intensity in the parafoveal subfields was associated negatively with logMAR VA and the retinal thickness in the corresponding subfields. The autofluorescence levels in the parafoveal subfield, except the nasal subfield, were lower in eyes with autofluorescent cystoid spaces in the corresponding subfield than in those without autofluorescent cystoid spaces. The autofluorescence level in the central subfield was related to foveal cystoid spaces but not logMAR VA or retinal thickness in the corresponding area. Conclusions Quantified FAF in the parafovea has diagnostic significance and is clinically relevant in DMO.

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Retinal Sensitivity Loss and Structural Disturbance in Areas of Capillary Nonperfusion of Eyes with Diabetic Retinopathy

Cited by 67 publications

References 25 publications

The Effects of Macular Ischemia on Visual Acuity in Diabetic Retinopathy

The Effects of Macular Ischemia on Visual Acuity in Diabetic Retinopathy

Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

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