Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy

Sakamoto, Atsushi; Nishijima, Kazuaki; Kita, Mihori; Oh, Hideyasu; Tsujikawa, Akitaka; Yoshimura, Nagahisa

doi:10.1007/s00417-009-1107-5

Cited by 133 publications

(102 citation statements)

References 27 publications

(26 reference statements)

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“…13,14 Compared with the classic examinations including biomicroscopy, OCT images have shown the detailed pathomorphology in MO associated with retinal vascular diseases including diabetic retinopathy (DR) and retinal vein occlusion (RVO), cystoid spaces, spongelike swelling, and serous retinal detachments (SRDs). 15,16 The integrity of outer layers of the fovea, the junction of the inner and outer segments, and the external limiting membrane also have been reported to be related to visual function in resolved MO associated with BRVO and DR. [17][18][19] However, it is unclear how an obstruction of a branch retinal vein results in a great diversity of morphology in the retinal vasculature and parenchyma. It also is not well understood how macular ischaemia affects the pathomorphology in the retinal parenchyma and vice versa.…”

Section: Introductionmentioning

confidence: 99%

Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Murakami

Tsujikawa

Miyamoto

et al. 2012

Eye

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Section: Introductionmentioning

confidence: 99%

Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Murakami

Tsujikawa

Miyamoto

et al. 2012

Eye

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“…Sakamoto et al suggested that the integrity of the foveal photoreceptor layer is associated with VA after resolution of DME through pars plana vitrectomy [17]. They showed that simple reduction in foveal thickness was insufficient to achieve good visual recovery, and that restoration of the structure of the photoreceptors to a more physiologic condition was required.…”

Section: Discussionmentioning

confidence: 99%

Restoration of photoreceptor layer and its prognostic value in eyes with macular edema due to branch retinal vein occlusion

Bayat¹,

Bölükbaşı²,

Çakir³

et al. 2018

Med-Science

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To evaluate the restoration of outer segment ellipsoid zone (EZ) layer and its prognostic value in visual gain following resolution of macular edema (ME) due to branch retinal vein occlusion (BRVO). In this retrospective study,33 eyes of 33 patients with ME due to BRVO who underwent intravitreal ranibizumab (IVR) injections were studied. All of the patients had the resolution of macular edema after IVR therapy. At baseline and final visit, SD-OCT scans were obtained. Best-corrected visual acuity (BCVA), central macular thickness (CMT) and integrity of outer segment ellipsoid zone (EZ) defects were determined. We divided the eyes with initial EZ defects into two groups. Group-1 had restoration of EZ and group-2 had EZ defects before and after treatment. 14 of 33 eyes (42.4%) did not have EZ defects and 19 of 33 eyes had EZ defects before treatment. 9 eyes (27.3%) had restoration of EZ defects and 2 patients (6.1%) had EZ defects after treatment while they did not have at initial visit. According to EZ change status (group-1 and group-2) the groups were similar in terms of initial BCVA and CMT. Group-1 had better final BCVA (p=0.005). There was a statically significant difference in BCVA improvement between groups (p=0.001). Disorganization of photoreceptors can have recovery after resolution of ME with ranibizumab treatment and to have better BCVA after resolution of ME, restoration of the structure of the photoreceptors is required.

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“…[7][8][9][10]20,21 Michalewski et al 6 sought correlations between macular morphology and visual acuity in patients with EMM using OCT. They reported that macular morphology and photoreceptor defects seemed to be prognostic factors in patients with EMM.…”

Section: Is/os Reflectivity In Epimacular Membrane I Toprak Et Almentioning

confidence: 99%

Decreased photoreceptor inner segment/outer segment junction reflectivity in patients with idiopathic epimacular membrane

Toprak

Yaylalı

Yıldırım

2014

Eye

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Purpose To assess the effects of idiopathic epimacular membrane (IEMM) on retinal pigment epithelium (RPE), photoreceptor inner segment/outer segment (IS/OS) junction, and external limiting membrane (ELM) reflectivities to determine functional alterations in these layers using optical coherence tomography (OCT) image analysis. Methods Fifty eyes of 50 patients with untreated IEMM and 41 eyes of 41 age-and sex-matched healthy controls with normal OCT scans were retrospectively reviewed. A single masked physician analyzed OCT images randomly. Reflectivity values of RPE, IS/OS junction, and ELM were obtained using 'plot profile' mode of a medical image processing computer software. Results The study comprised 50 patients with untreated IEMM and age-and sexmatched 41 control subjects (P40.05). Image analysis demonstrated that IS/OS junction and ELM had significantly lower reflectivity in patients with IEMM compared with those of the control eyes (P ¼ 0.008, P ¼ 0.009, respectively). However, RPE reflectivity did not differ between two groups (P ¼ 0.100). Correlation analyses showed no significant associations between reflectivity values and corrected visual acuity (P40.05). Conclusion In patients with IEMM, photoreceptor IS/OS junction and ELM seem to have lower reflectivity, which might indicate impaired functionality even though these layers are not apparently damaged on OCT imaging.

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Association between foveal photoreceptor status and visual acuity after resolution of diabetic macular edema by pars plana vitrectomy

Abstract: The postoperative photoreceptor status of the fovea is closely related to the final VA after resolution of DME by PPV.

Cited by 133 publications

References 27 publications

Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Restoration of photoreceptor layer and its prognostic value in eyes with macular edema due to branch retinal vein occlusion

Decreased photoreceptor inner segment/outer segment junction reflectivity in patients with idiopathic epimacular membrane

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