Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Murakami, Tomoaki; Tsujikawa, Akitaka; Miyamoto, Kazuaki; Sakamoto, Atsushi; Ota, Megumi; Ogino, Ken; Yoshimura, Nagahisa

doi:10.1038/eye.2012.85

Cited by 39 publications

(22 citation statements)

References 42 publications

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“…The results showed that cystoid spaces located in the outer plexiform layer correlated with a good prognosis, which was in agreement with a previous study that reported that cystoid spaces were located mainly in the inner nuclear layer in longstanding BRVO compared with those located in the outer plexiform layer in recent onset BRVO. 36 Moreover, this present study also demonstrated that venous obstruction in the inferotemporal quadrant correlated with a good prognosis following IVTA injection compared with superotemporal quadrant obstruction.…”

Section: Discussionsupporting

confidence: 75%

“… 11 Increased retinal blood flow in the occluded venules before injection might be associated with a reduction of ME after intravitreal bevacizumab. 25 As the ischaemic type of BRVO is generally correlated with a poor prognosis, 36 the morphological pattern was further analysed in this type; although it should be noted that some patients with ischaemic BRVO in the present study did have a good response to IVTA treatment. The present analysis of the resolution and relapsing subgroups ( Table 4 ) demonstrated that a broken foveal capillary ring correlated with a poor prognosis, which may partially support the theory that the disruption of retinal blood flow may play an important role in recurrent ME.…”

Section: Discussionmentioning

confidence: 84%

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Factors correlated with the resolution of macular oedema after one dose injection of intravitreal triamcinolone acetonide treatment in branch retinal vein occlusion

Zhang

et al. 2016

J Int Med Res

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ObjectiveTo investigate the predictive baseline factors for a successful outcome following one dose of intravitreal triamcinolone acetonide (IVTA) in patients with macular oedema (ME) caused by branch retinal vein occlusion (BRVO).MethodsThis retrospective study enrolled patients with ME (macular retinal thickness [MRT] ≥ 300 µm) due to BRVO who still had ME 3 months after grid laser photocoagulation. Patients were divided according to treatment into an IVTA group and a laser-only group. The resolution of ME was documented at months 3 and 6.ResultsA total of 154 eyes with ME were investigated: IVTA group (90 eyes) and laser-only group (64 eyes). Predictive factors for successful IVTA treatment were younger age, shorter duration of ME, initial onset ME, accompanied by serous retinal detachment, few concomitant systemic diseases and nonischaemic BRVO. A broken foveal capillary ring was related to a poor treatment outcome. Eyes with cystoid spaces in the outer plexiform layer were more likely to have a good treatment response.ConclusionIVTA is effective for resolving ME due to BRVO after grid laser photocoagulation treatment.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 84%

Factors correlated with the resolution of macular oedema after one dose injection of intravitreal triamcinolone acetonide treatment in branch retinal vein occlusion

Zhang

et al. 2016

J Int Med Res

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“…In the RELATE study [13], the mean duration from onset to the initial IVR and laser photocoagulation was 16.8 months. Murakami et al [20] report that 100 % of BRVO patients with a disease duration of over 1 year exhibited aneurysmal dilatation of the PCN. Thus, we consider that the prolonged time between the onset of BRVO and treatment commencement in the RELATE study likely contributed to the formation of leaking MAs and capillaries in the PCN.…”

Section: Discussionmentioning

confidence: 98%

Effect of leaking capillaries and microaneurysms in the perifoveal capillary network on resolution of macular edema by anti-vascular endothelial growth factor treatment

et al. 2016

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“…9,10 The damaged capillaries can lead to a permanence of the nonperfused areas by the action of vasoproliferative agents such as VEGF that are released under the retinal hypoxic conditions. 11 Thus, it is important to investigate the site of VEGF expression to determine the mechanisms causing the retinal edema and ischemic areas in eyes with a RVO.…”

mentioning

confidence: 99%

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

Nishinaka

Inoue

Fuma

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine the relationship between retinal morphologic changes and molecules involved in the changes after anti-VEGF treatment in the retina of retinal vein occlusion (RVO) murine model. METHODS. The studies were performed on murine RVO model created by laser irradiation of retinal veins. The site of VEGF expression was determined by immunostaining, and the retinal thickness was measured in the images obtained by optical coherence tomography. The levels of VEGF-related and inflammatory factors after an intravitreal injection of anti-VEGF antibody immediately or 7 days after laser irradiation were determined by Western blotting. RESULTS. The level of VEGF increased in all retinal layers 1 day after laser irradiation, and expression was higher in the partially perfused areas than in the completely nonperfused areas. In eyes with high expression level of VEGF, early administration of anti-VEGF antibody reduced the retinal thickness, and expressions of VEGF and inflammatory factors returned to normal levels. However, the levels of phosphorylated protein kinase B (AKT), extracellular signal-regulated kinase 1 and 2 (ERK1/2), and endothelial nitric oxide synthase (eNOS) were increased by early administration of anti-VEGF antibody. On the other hand, in eyes with low concentration of VEGF, late injection of anti-VEGF antibody induced retinal thinning and the concentrations of phosphorylated AKT, ERK1/2, and eNOS were lower than that in normal group. Furthermore, anti-VEGF antibody lessened the reduction of aquaporin-4. CONCLUSIONS. These findings indicate that the effect of anti-VEGF antibody is most likely dependent on its effect on the intraocular VEGF levels.

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Relationship between perifoveal capillaries and pathomorphology in macular oedema associated with branch retinal vein occlusion

Cited by 39 publications

References 42 publications

Factors correlated with the resolution of macular oedema after one dose injection of intravitreal triamcinolone acetonide treatment in branch retinal vein occlusion

Factors correlated with the resolution of macular oedema after one dose injection of intravitreal triamcinolone acetonide treatment in branch retinal vein occlusion

Effect of leaking capillaries and microaneurysms in the perifoveal capillary network on resolution of macular edema by anti-vascular endothelial growth factor treatment

Pathophysiological Role of VEGF on Retinal Edema and Nonperfused Areas in Mouse Eyes With Retinal Vein Occlusion

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