Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Yoshitake, Shin; Murakami, Tomoaki; Uji, Akihito; Unoki, Noriyuki; Dodo, Yoko; Horii, Takahiro; Yoshimura, Nagahisa

doi:10.1038/eye.2015.25

Cited by 18 publications

(23 citation statements)

References 39 publications

(50 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In contrast to the study by Yoshitake et al in 2015, they stated LogMAR VA was correlated negatively with the mean FAF signals in the parafoveal area. (27) Differences between this study and ours are larger study population (103 eyes) in comparison to ours (50 eyes) and using cSLO for FAF rather than fundus camera in our study.…”

Section: Discussioncontrasting

confidence: 59%

See 1 more Smart Citation

Correlation Between Visual Functions and Optical Coherence Tomography, Fundus Auto Fluorescence and Fundus Fluorescein Angiography Findings in Treatment-Naive Diabetic Macular Edema

Eldin

Rashed

Embabi

et al. 2020

Ain Shams Medical Journal

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 59%

“…Also, a study done by Yoshitake and his colleagues (2015) showed the same previous association. (27) conclusion:…”

Section: Discussionmentioning

confidence: 97%

Correlation Between Visual Functions and Optical Coherence Tomography, Fundus Auto Fluorescence and Fundus Fluorescein Angiography Findings in Treatment-Naive Diabetic Macular Edema

Eldin

Rashed

Embabi

et al. 2020

Ain Shams Medical Journal

View full text Add to dashboard Cite

“…After removing duplicates, the updated search in October 2016 yielded 380 new references. Eighteen references were retrieved for screening on full text, [77][78][79][80][81][82][83][84][85][86][87][88][89][90][91][92][93][94] of which four met the criteria for inclusion in the systematic review. 79,80,82,91 The four new references reported four unique studies.…”

Section: Results Of the Review Updatementioning

confidence: 99%

Fundus autofluorescence imaging: systematic review of test accuracy for the diagnosis and monitoring of retinal conditions

Frampton

Kalita

Payne

et al. 2017

Eye

View full text Add to dashboard Cite

We conducted a systematic review of the accuracy of fundus autofluorescence (FAF) imaging for diagnosing and monitoring retinal conditions. Searches in November 2014 identified English language references. Sources included MEDLINE, EMBASE, the Cochrane Library, Web of Science, and MEDION databases; reference lists of retrieved studies; and internet pages of relevant organisations, meetings, and trial registries. For inclusion, studies had to report FAF imaging accuracy quantitatively. Studies were critically appraised using QUADAS risk of bias criteria. Two reviewers conducted all review steps. From 2240 unique references identified, eight primary research studies met the inclusion criteria. These investigated diagnostic accuracy of FAF imaging for choroidal neovascularisation (one study), reticular pseudodrusen (three studies), cystoid macular oedema (two studies), and diabetic macular oedema (two studies). Diagnostic sensitivity of FAF imaging ranged from 32 to 100% and specificity from 34 to 100%. However, owing to methodological limitations, including high and/or unclear risks of bias, none of these studies provides conclusive evidence of the diagnostic accuracy of FAF imaging. Study heterogeneity precluded meta-analysis. In most studies, the patient spectrum was not reflective of those who would present in clinical practice and no studies adequately reported whether FAF images were interpreted consistently. No studies of monitoring accuracy were identified. An update in October 2016, based on MEDLINE and internet searches, identified four new studies but did not alter our conclusions. Robust quantitative evidence on the accuracy of FAF imaging and how FAF images are interpreted is lacking. We provide recommendations to address this.

show abstract

“…New retinal imaging technologies have been recently developed to image the retina with more details and provide retinal functional assessment, which may potentially improve our DR screening practices in the future. Newer technologies such as portable handheld nonmydriatic cameras, 107 enhanced depth imaging OCT, [108][109][110] swept source OCT, 111 OCT angiography, Doppler OCT, adaptive optics, retinal function assessment, retinal oximetry, metabolic imaging, and fundus autofluorescence 112 are beginning to find applications in DR management and have the potential to change the landscape further in the future. However, more large-scale studies on the diagnostic performance and cost-effectiveness of these imaging technologies in the primary care setting are required before widespread recommendations for their use in routine DR screening can be made.…”

Section: Future Possibilitiesmentioning

confidence: 99%

Retinal Imaging Techniques for Diabetic Retinopathy Screening

Goh

Cheung

Sim

et al. 2016

J Diabetes Sci Technol

118

View full text Add to dashboard Cite

The prevalence of diabetes mellitus (DM) is projected to approach 600 million people worldwide by 2035 and there are concerns about a potential diabetes epidemic in Asia. 1 Diabetic retinopathy (DR), a complication of DM, afflicts a third of diabetics and is the principal cause of vision loss among the working age group in developed countries 2 and remains a leading cause of preventable blindness. 3 The proportion of visual impairment worldwide caused by DR has increased. 4 Diabetic macular edema (DME), characterized by increased vascular permeability and the deposition of hard exudates at the central retina, can develop at any stages of DR and afflicts 21 million people globally. 5Through regular eye examinations and adequate DM management, the diabetes-related vision loss can be prevented in 98% of cases. 6,7 Primary interventions, such as intensive glycemic and blood pressure control, can reduce the incidence and progression of DR and DME, while secondary interventions, such as laser photocoagulation and injections of anti-vascular endothelial growth factor drugs, may prevent development and progression of vision loss. [8][9][10][11][12][13] Therefore, early detection of DR and DME through screening programs and appropriate referral for therapy are essential to preserving vision in individuals with diabetes. DR screening has been shown to be a cost-effective method of preventing diabetes-related vision loss.14,15 Since blindness from DR and DME is preventable from both public health screening and clinical management perspectives, it is important to precisely identify persons who have DR/DME for early intervention before they progress to severe visionthreatening stages. 16Current DR screening programs typically employ retinal fundus photography and manual assessment of DR, 17 but this approach requires highly skilled readers which is labor-intensive and costly. Moreover, fundus photography as a technique Abstract Due to the increasing prevalence of diabetes mellitus, demand for diabetic retinopathy (DR) screening platforms is steeply increasing. Early detection and treatment of DR are key public health interventions that can greatly reduce the likelihood of vision loss. Current DR screening programs typically employ retinal fundus photography, which relies on skilled readers for manual DR assessment. However, this is labor-intensive and suffers from inconsistency across sites. Hence, there has been a recent proliferation of automated retinal image analysis software that may potentially alleviate this burden cost-effectively. Furthermore, current screening programs based on 2-dimensional fundus photography do not effectively screen for diabetic macular edema (DME). Optical coherence tomography is becoming increasingly recognized as the reference standard for DME assessment and can potentially provide a cost-effective solution for improving DME detection in large-scale DR screening programs. Current screening techniques are also unable to image the peripheral retina and require pharmacological pupil dilation; ul...

show abstract

Clinical relevance of quantified fundus autofluorescence in diabetic macular oedema

Cited by 18 publications

References 39 publications

Correlation Between Visual Functions and Optical Coherence Tomography, Fundus Auto Fluorescence and Fundus Fluorescein Angiography Findings in Treatment-Naive Diabetic Macular Edema

Correlation Between Visual Functions and Optical Coherence Tomography, Fundus Auto Fluorescence and Fundus Fluorescein Angiography Findings in Treatment-Naive Diabetic Macular Edema

Fundus autofluorescence imaging: systematic review of test accuracy for the diagnosis and monitoring of retinal conditions

Retinal Imaging Techniques for Diabetic Retinopathy Screening

Contact Info

Product

Resources

About