Retinal perfusion changes in radiation retinopathy

Rose, Kalpana; Krema, Hatem; Durairaj, Priya; Dangboon, Wantanee; Chavez, Yael; Kulasekara, Susith; Hudson, Christopher

doi:10.1111/aos.13797

Cited by 27 publications

(38 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After irradiation of retina cell culture in vitro at doses ranging from 1 up to 2 Gy, which is the incidental dose received by the healthy retina per fraction when the standard treatment is delivered to the brain, at day two, an evident loss of cell viability and βIII-tubulin immunostaining was evident, while highlighting marked neuritic damage [2]. In eight patients who developed retinopathy following plaque radiation treatment for choroidal melanoma, the average total retinal blood flow (TRBF) was significantly lower, and retinal blood oxygen saturation indications were higher in the retinopathy eye, compared with the other, which indicates alterations of retinal vascularization, similar to a rapidly developing diabetic retinopathy [113].…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Cerebro-Ophthalmic Effects in Humans

Loganovsky

Marazziti

Fedirko

et al. 2020

Life

View full text Add to dashboard Cite

Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both cognitive and visual impairments. The aim of this paper was to review and analyze the current literature, and to comment on the ensuing findings in the light of our personal contributions in this field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus, Embase, PsycINFO and Google Scholar English papers published from January 2000 to January 2020. The results showed that prenatally or childhood-exposed individuals are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood and medical/interventional radiologists, the most frequent IR-induced ophthalmic effects include cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with specific neurocognitive deficits. According to available information that eye alterations may induce or may be associated with brain dysfunctions and vice versa, we propose to label this relationship “eye-brain axis”, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable markers of possible low dose IR-induced brain damage.

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Cerebro-Ophthalmic Effects in Humans

Loganovsky

Marazziti

Fedirko

et al. 2020

Life

View full text Add to dashboard Cite

show abstract

“…In a small study of eight patients with radiation retinopathy after treatment for CM, a reduced blood flow with increased ArtSat and VenSat was identified in affected eyes. 13 No pretreatment values were reported however. An interesting comparison can be made with studies on retinal vasculature in treatment-naïve melanoma and nevi using OCTA.…”

Section: Discussionmentioning

confidence: 99%

“… 12 After treatment for CM, altered levels of retinal arterial and venous oxygenation were detected in patients with radiation retinopathy. 13 No pretreatment values were determined however, although such information might help to understand why some eyes develop radiation retinopathy and others do not. To the best of our knowledge, no studies on retinal oximetry in untreated melanoma or nevus eyes have as yet been reported.…”

mentioning

confidence: 99%

Retinal Oximetry Is Altered in Eyes With Choroidal Melanoma but Not in Eyes With Choroidal Nevi

Brouwer

Marinković

Bleeker

et al. 2019

Retina

View full text Add to dashboard Cite

show abstract

“…High-dose brachytherapy, which uses iodine-125 b-ray sources (that can promote radiation retinopathy) to treat intraocular melanoma of the choroid, is accompanied by an increase in retinal oxygenation and reduced blood flow in the exposed eye (Rose et al 2018). These low-LET IRinduced changes in retinal microvasculature are a characteristic of diabetic retinopathy.…”

Section: Ocular Inflammation Including Uveitismentioning

confidence: 99%

“…We found that hypoxic LECs and lenses have a relatively low radio-sensitivity, about twothirds of maximum OER; the retina, however, is more vulnerable to oxidative stress, as its well-oxygenated cells ($22 mmHg O 2 ) endure 90% maximum OER (Figures 3 and 5). Indeed, the vascular retina is prone to IR damage by the oxygen effect (Rose et al 2018).…”

Section: Oxygen Effectexploratory Analysismentioning

confidence: 99%

Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation

Richardson

Ainsbury

Prescott

et al. 2020

International Journal of Radiation Biology

View full text Add to dashboard Cite

Purpose: Since the exact development of posterior subcapsular cataracts (PSCs) is poorly understood, we review various risk factors and propose a two-stage etiology for PSCs. Methods: The biological mechanisms associated with age-related cataracts (primarily nuclear cataracts, cortical cataracts and PSCs) were reviewed in relation to selected risk factors that induce PSCs (including atopy, diabetes, hypoparathyroidism, myopia, retinitis, solar radiation, steroid use, uveitis, vitrectomy and ionizing radiation). We particularly focused on ionizing radiation, as this is known to be a risk factor specific to PSCs. Based on an analysis of the reviewed material, we propose a detailed explanation of the etiology of PSCs. Conclusions: Lens epithelial cells (LECs) and lens fiber cells are normally hypoxic and therefore very sensitive to changes in oxidative stress, as quantified by the radiation oxygen effect. We hypothesize that the development of PSC opacities is a two-stage process. Stage I, early in life, is driven by risk factors that promote oxidative stress and ion-pump disruption, harming lens fibers and causing aberrant LECs to proliferate and ectopically migrate as Wedl cells (perhaps by processes associated with an epithelial to mesenchymal transition) to the posterior pole region. After a latent period, in Stage II, the development of PSCs advances mainly due to chronic inflammation and other premature aging-related mechanisms that promote mature vacuolar or plaque PSC. This two-stage hypothesis of PSC etiology accounts for risk factors, such as aging, diabetes and ionizing radiation, which directly affects LECs and the lens. In addition, these risk factors can damage other ocular regions, such as the retina and vitreous, that also indirectly contribute to the development of PSCs. It is possible that the incidence of PSCs may be reduced by reversing the effects of Stage I through various means, including ocular antioxidants.

show abstract

Retinal perfusion changes in radiation retinopathy

Abstract: The ionizing radiation seems to have an impact on the TRBF, SaO and SvO , clinically presenting similar to a rapidly developing diabetic retinopathy. The results show an altered retinal vascular physiology in patients with radiation-related retinopathy.

Cited by 27 publications

References 34 publications

Radiation-Induced Cerebro-Ophthalmic Effects in Humans

Radiation-Induced Cerebro-Ophthalmic Effects in Humans

Retinal Oximetry Is Altered in Eyes With Choroidal Melanoma but Not in Eyes With Choroidal Nevi

Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation

Contact Info

Product

Resources

About