Retinal Oximetry Is Altered in Eyes With Choroidal Melanoma but Not in Eyes With Choroidal Nevi

Brouwer, Niels J.; Marinković, Marina; Bleeker, J.C.; Filali, Mariam el; Stefánsson, Einar; Luyten, Gregorius P M; Jager, Martine J.

doi:10.1097/iae.0000000000002719

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Peripheral and macular branch segments were selected to start from the branching point and consist of the longest unbranched segment not exceeding a length of 50 pixels. Because 1 pixel corresponded to approximately 9.3 micrometers at the retinal plane, 13 the maximum length of the vessel segment was approximately 465 micrometers.…”

Section: Methodsmentioning

confidence: 99%

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Drachmann,

Jeppesen,

Bek

2023

Invest. Ophthalmol. Vis. Sci.

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Purpose A recent study has shown that an increase in the arterial blood pressure of approximately 10 mm Hg in healthy persons can increase the oxygen saturation in venules from the retinal periphery but not from the macular area. The purpose of the present study was to investigate whether a higher increase in blood pressure has further effects on oxygen saturations and whether this is accompanied with changes in retinal blood flow. Methods In 30 healthy persons, oxygen saturation, diameter, and blood flow were measured in arterioles to and venules from the retinal periphery and the macular area. The experiments were performed before and during an experimental increase in arterial blood pressure of (mean ± SD) 18.3 ± 6.2 mm Hg. Results A higher number of venules than arterioles branching from the temporal vascular arcades to the macular area was balanced by a smaller diameter of the venules. Isometric exercise induced significant contraction of both peripheral and macular arterioles ( P < 0.01 for both comparisons) and significant increase in oxygen saturation in both peripheral and macular venules ( P < 0.001 for both comparisons). This was accompanied with a significant increase in the blood flow in the peripheral arterioles and venules ( P = 0.4 for both comparisons), but not in their macular counterparts ( P > 0.06 for both comparisons). Conclusions Increased systemic blood pressure leading to arterial contraction and increased venous oxygen saturation in the retina in normal persons can increase peripheral blood flow without significant effects on macular blood flow. This may contribute to explaining regional differences in the response pattern of retinal vascular disease.

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Section: Methodsmentioning

confidence: 99%

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Drachmann,

Jeppesen,

Bek

2023

Invest. Ophthalmol. Vis. Sci.

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“…Oximetry measures the oxygen saturation of the arterial and venous blood in the retinal vessels and could therefore be a potential biomarker of tumor metabolism [18,19]. In a cohort of 45 UM patients, an increase in oxygen consumption was found in the tumor eye in comparison to the fellow eye, while in 42 patients with a choroidal nevus, no difference in oxygen consumption occurred between the affected and fellow eye [20]. Although this finding is in agreement with ear- lier studies in showing an increased metabolic activity in UM [21,22], the variation between subjects was too wide to use this technique to directly differentiate between a choroidal melanoma and nevus.…”

Section: Oximetry and Oct-a Of Choroidal And Iris Tumorsmentioning

confidence: 99%

Outcome Measures of New Technologies in Uveal Melanoma: Review from the European Vision Institute Special Interest Focus Group Meeting

Beenakker¹,

Brouwer²,

Chau³

et al. 2022

Ophthalmic Res

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Uveal Melanoma (UM) is the most common primary intra-ocular tumor in adults. New diagnostic procedures and basic science discoveries continue to change our patient management paradigms. A recent meeting of the European Vision Institute (EVI) special interest focus group was held on “Outcome Measures of New Technologies in Uveal Melanoma”, addressing the latest advances in UM, starting with genetic developments, then moving on to imaging and treatment of the primary tumor, as well as to investigating the most recent developments in treating metastases, and eventually taking care of the patient’s wellbeing. This review highlights the meeting’s presentations in the context of the published literature.

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Creating a Science Project: Advice from Personal Experience

Jager

2022

Global Perspectives in Ocular Oncology

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Retinal Oximetry Is Altered in Eyes With Choroidal Melanoma but Not in Eyes With Choroidal Nevi

Cited by 5 publications

References 30 publications

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Increased Oxygen Saturation in Retinal Venules During Isometric Exercise Is Accompanied With Increased Peripheral Blood Flow in Normal Persons

Outcome Measures of New Technologies in Uveal Melanoma: Review from the European Vision Institute Special Interest Focus Group Meeting

Creating a Science Project: Advice from Personal Experience

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