Retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia

Budakoglu, Ozlem; Ozdemir, Kubra; Şafak, Yasir; Şen, Emine; Taskale, Busra

doi:10.1080/08164622.2021.1878816

Cited by 21 publications

(13 citation statements)

References 20 publications

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“…The small sample sizes, difficulties in interpretation and no unanimous protocols (on parameters that should be taken into account) limit the level of validity of the findings and may lead to false-negative or -positive results. However, in other studies, the sample sizes were similar, for example, 28 patients with SZ in the recent study by Silverstein and colleagues [ 52 ], 30 patients with SSD in the study of Alizedah and colleagues [ 49 ] and 22 patients in the study of Budakoglu and colleagues [ 53 ]. The small sample size corresponded to the lack of differentiation between the gender, disease duration and type of medications taken.…”

Section: Discussionmentioning

confidence: 86%

Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder

Koman-Wierdak

Róg

Brzozowska

et al. 2021

JCM

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Purpose: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA). Methods: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy subjects were examined with OCTA. The radiant peripapillary capillary (RPC) density and RNFL thickness were measured in the peripapillary area. Moreover, macular thickness and vessel density were measured in both superficial and deep layers. Results: Significantly decreased values of vessel density in the macular deep vascular complex were found in the eyes of patients with SZ, compared to BD and the control group. The macular thickness in the whole vascular complex and in the fovea was significantly lower in SZ and BD group than in the control group. The radiant peripapillary vascular density and RNFL thickness were similar across groups. Conclusions: The retinal microvascular dysfunction occurs in the macula in patients with SZ and BD, but not around optic disc. OCTA can become an essential additional diagnostic tool in detection of psychiatric disorders.

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Section: Discussionmentioning

confidence: 86%

Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder

Koman-Wierdak

Róg

Brzozowska

et al. 2021

JCM

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“…We found that MDD patients had lower retinal vessel density, thinner SFCT, and poorer visual function compared to HCs. Recently, abnormalities in retinal vessel density and structure have also been demonstrated in psychiatric disorders, such as BD and SP ( 26 , 27 , 38 – 40 ). As for MDD, although there is no definite evidence directly proving the association between MDD and retinal vessel density, retinal vascular dysfunction and endothelial damage in MDD patients have been confirmed in previous studies ( 41 , 42 ).…”

Section: Discussionmentioning

confidence: 99%

“…Optical coherence tomography angiography (OCTA) provides a unique, quantitative, non-invasive method of assessing the retinal structural and microvascular system, and has been one of the fastest growing and most prospective non-invasive indicators in the field of ophthalmology, and even extra-ophthalmology ( 23 ). Interestingly, the use of OCTA as the indicator for neurodegenerative diseases, such as cerebrovascular disease, cognitive impairment and schizophrenia (SP), have been widely reported in recent years ( 24 – 27 ). However, the relationship between MDD and the retinal vasculature remains controversial.…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Retina−Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View

Liu

Lai

et al. 2022

Front. Psychiatry

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BackgroundClinically effective markers for the diagnosis of major depressive disorder (MDD) are lacking. Alterations in retinal features are closely related to the pathophysiological progression of MDD. However, the reliable retina-related diagnostic model for MDD remains to be developed. Thus, our study aimed to quantitatively evaluate retinal vascular and structural changes in MDD patients and to develop a reliable diagnostic model of MDD based on retinal parameters.MethodsSeventy-eight patients with MDD and 47 healthy controls (HCs) underwent retinal vessel density and structure examination using optical coherence tomography angiography and visual field examination using perimetry. Independent-sample t test was used to assess the differences in retinal parameters between the groups. Meanwhile, we constructed the corresponding retina-based diagnostic model by LASSO logistic regression. Finally, the diagnostic ability of the model was evaluated by area under the curve (AUC) of receiver operating characteristic curves and calibration plot of nomogram.ResultsMDD patients showed lower retinal vessel density (including radial peripapillary capillary vessel density, superficial and deep capillary plexus vessel density), thinner subfoveal choroidal thickness, and poorer visual fields compared to HCs (all p < 0.05). Furthermore, a retina-based diagnostic model was constructed and shows a strong diagnostic capability for MDD (AUC = 0.9015, p < 0.001).ConclusionPatients with MDD showed distinct retinal features compared to HCs. The retina-based diagnostic model is expected to be a necessary complement to the diagnosis of MDD.

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“…A more recent study found an increase in superficial skeleton vessel density, choriocapillaris skeleton vessel density, and choriocapillaris vessel density in individuals with schizophrenia compared to controls (32). When looking at peripapillary vascular density (vascular density surrounding the optic nerve), Budakoglu et al (33) found that individuals with schizophrenia had reduced density in one quadrant compared to controls.…”

Section: Utility Of Octamentioning

confidence: 98%

OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment

Green

Choi

Ramchandran

et al. 2022

Front. Digit. Health

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The human retina and retinal imaging technologies continue to increasingly gain the attention of schizophrenia researchers. With the same embryologic origin as the brain, the retina offers a window into neurovascular changes that may underlie disease. Recently, two technologies that have already revolutionized the field of ophthalmology, optical coherence tomography (OCT), and a functional extension of this, optical coherence tomography angiography (OCTA), have gained traction. Together, these non-invasive technologies allow for microscopic imaging of both structural and vascular features of the retina. With ease of use and no side effects, these devices are likely to prove powerful digital health tools in the study and treatment of schizophrenia. They may also prove key to discovering disease relevant biomarkers that underly neurodevelopmental and neurodegenerative aspects of conditions such as schizophrenia.

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Retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia

Cited by 21 publications

References 20 publications

Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder

Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder

Development of a Novel Retina−Based Diagnostic Score for Early Detection of Major Depressive Disorder: An Interdisciplinary View

OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment

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