Retinal Nerve Fiber Layer Measurements in Myopia: An Optical Coherence Tomography Study

Leung, Christopher Kai-Shun; Mohamed, Shaheeda; Leung, KY; Cheung, Carol Y.; Chan, Sylvia Lai-wa; Cheng, Daphne Ka-yee; Lee, August Ki-cheung; Leung, Gilberto Ka Kit; Rao, Srinivas K; Lam, Dennis Shun Chiu

doi:10.1167/iovs.06-0545

Cited by 330 publications

(313 citation statements)

References 30 publications

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“…Some authors report the negative effect of myopia (or axial length) on RNFL thickness. 14,20 In the present study, the average refractive error of men was smaller than that of women (men: À2.0 ± 2.2D, women: À0.9 ± 2.2D, P ¼ 0.002), whereas the average age of each group was almost the same (men: 49.8 ± 14.8 years women: 50.2±13.6 years, non-significant). Refractive error, however, was not a significant predicting factor for RNFL thickness in the present multiple regression analysis, and it is hard to reconcile the large difference between genders.…”

Section: Discussioncontrasting

confidence: 56%

Retinal nerve fiber layer thickness in patients with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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Purpose To study retinal nerve fiber layer (RNFL) thickness in patients with retinitis pigmentosa (RP). Design Cross-sectional observational study. Methods One hundred and thirty-seven eyes of 137 patients with RP were examined. The effect of age, gender, laterality, inheritance trait, spherical equivalent refractive error, visual acuity, and the extent of visual field defect on RNFL thickness measured with optical coherence tomography were analyzed by a multiple linear regression model. Results The average RNFL thickness was 104.1±21.7 lm. The multiple R 2 for the model was 0.349. Among the variables studied, ageing and being male were significant risk factors for thinner RNFL thickness. RNFL thickness was not correlated with inheritance trait, laterality, refractive error, visual acuity, or the extent of visual field defect. Conclusion RNFL thickness in RP patients was not correlated with visual function but ageing as in the normal subjects. Currently proposed therapies, including photoreceptor rescue/transplantation and visual prosthesis, are based on the premise that the inner retinal structures are relatively retained despite the profound loss of photoreceptors. The present result supports this notion.

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Section: Discussioncontrasting

confidence: 56%

Retinal nerve fiber layer thickness in patients with retinitis pigmentosa

Oishi

Otani

Sasahara

et al. 2008

Eye

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“…Controversies exist among the results of studies that investigated the influence of myopia on RNFL thickness (17)(18)(19)(20)(21). However, there are only two generally acknowledged opinions.…”

Section: Comparisons Between Se Groups (P-value) --------------------mentioning

confidence: 99%

Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Zha

Zhuang

Lin

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the retinal nerve fiber layer (RNFL) thickness of myopic subjects using Spectralis optical coherence tomography (OCT) and to determine variations with age and sex. A total of 271 Chinese participants with a spherical equivalent <+0.50 diopters were enrolled in the research. All subjects underwent a full ophthalmic examination. RNFL thickness was measured and compared according to sex, age and spherical equivalent. No significant difference was demonstrated between RNFL thickness in males and females. No significant difference was observed between RNFL thickness of the two age groups (≤12 years old and >12 years old). Significant differences were observed in all subfields of RNFL thickness among different spherical equivalent groups (P<0.05). In conclusion, myopia did have special influence on RNFL thickness, which was not related to sex or age.

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“…Furthermore, rotations of the optic nerve are expected to cause a shift of RNFL entering the optic nerve head. In these eyes, the automatic segmentation protocols used in commercially available OCT machines could not accurately measure the thickness of the RNFL, and therefore highly myopic patients were among the most difficult patients to evaluate for glaucoma 7,72,73 (Figure 5). The pattern of RNFL distribution was altered in high myopes with thinner average, superior, nasal, and inferior but thicker temporal nerve fiber layer thickness and a temporal shift in the superior and inferior peak locations.…”

Section: Optic Nerve Headmentioning

confidence: 99%

“…OCT studies of altered biometry and topography of retinal and choroidal layers enabled evaluation of their correlations with demographics, visual function, and fundoscopic observations in pathologic myopia. 7 Furthermore, OCT is indispensable in the diagnosis and monitoring of the spectrum of visual impairing conditions, for example, glaucoma and diabetic macular edema. This review summarizes current findings on the application of OCT as a tool to study pathologic myopia and discuss the clinical implications of these findings as well as future research directions.…”

Section: Introductionmentioning

confidence: 99%