Advances of optical coherence tomography in myopia and pathologic myopia

Ng, Danny Siu-Chun; Cheung, Carol Y.; Luk, Franklin T.; Mohamed, Shaheeda; Brelén, Mårten; Yam, Jason C.; Tsang, Chun Wai; Lai, Timothy Y. Y.

doi:10.1038/eye.2016.47

Cited by 74 publications

(55 citation statements)

References 104 publications

(124 reference statements)

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“…As in other fields of ophthalmology, OCT has now become the most frequently used tool for characterising alterations in ocular tissues due to myopia 17. The development of enhanced depth imaging (EDI) and swept-source OCT (SS-OCT) with its higher wavelength in the order of 1050 nm now allows for improved penetration into deeper layers, while the speed of capture and software enhancements enable for wider field of scans.…”

Section: Introductionmentioning

confidence: 99%

Imaging in myopia: potential biomarkers, current challenges and future developments

et al. 2019

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Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. However, imaging the eye with high myopia accurately has its challenges and limitations, which are important for clinicians to understand in order to choose the best imaging modality and interpret the images accurately. In this review, we present the current imaging modalities available from the anterior to posterior segment of the myopic eye, including the optic nerve. We summarise the clinical indications, image interpretation and future developments that may overcome current technological limitations. We also discuss potential biomarkers for myopic progression or development of complications, including basement membrane defects, and choroidal atrophy or choroidal thickness measurements. Finally, we present future developments in the field of myopia imaging, such as photoacoustic imaging and corneal or scleral biomechanics, which may lead to innovative treatment modalities for myopia.

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Section: Introductionmentioning

confidence: 99%

Imaging in myopia: potential biomarkers, current challenges and future developments

et al. 2019

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“…Pathological myopia is defined by an axial length of the eye greater than 26 mm and by a refractive error of −6 dioptres (D) or more, associated with complications of the posterior segment due to progressive and excessive elongation of the globe 1. Progressive posterior segment elongation is accompanied by degenerative changes, including the sclera, optic disc, choroid, Bruch's membrane, retinal pigment epithelium (RPE) and neural retina.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography of myopic choroidal neovascularisation

et al. 2016

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“…Since the axial length is the in uencing factor of fundus blood vessel density [3] and the eye volume is smaller in short eyes, so the IOP uctuation is much more severe in surgery. Besides, fundus vessels are straight and fragile in long eyes, being stretched as the result of the extension of eyeball [38]. Moreover, because of the large eye volume, the pressure on the eyeball wall is uneven during the operation [39].…”

Section: Discussionmentioning

confidence: 99%

Optical coherence tomography angiography evaluation of the effects of phacoemulsification cataract surgery on macular hemodynamics in Chinese normal eyes

Jia

Wei

Song³

2020

Preprint

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Background：To quantitatively evaluate the possible effects of phacoemulsification cataract surgery on macular hemodynamics using optical coherence tomography angiography (OCTA).Methods：Prospective observational study. Superficial and deep macular vascular densities as well as parameters of foveal avascular zone (FAZ) were measured preoperatively (baseline) and at 1 day, 1 week and 4 weeks postoperatively in normal eyes (≥22 mm and ≤24 mm) of patients scheduled for phacoemulsification cataract surgery with intraocular lens implantation. Correlations between the rate of change of pre- and post-operative vascular densities and surgical parameters were analyzed.Results: 123 eyes of 107 patients were recruited. Compared with baseline measurements, no statistically significant variation was found in macular vascular densities of 1 day after surgery (P>0.05). While both superficial and deep macular vascular densities were significantly increased postoperatively on week 1 and week 4 (P<0.05; P<0.05). There were no statistically significant differences in any of the FAZ parameters between the baseline measurements and the entire follow-up period (P>0.05 for all). There were no statistically significant correlations between main surgical parameters and the changes of macular vascular densities.Conclusions: In normal eyes, macular blood perfusion gradually increased after phacoemulsification cataract surgery and was stabilized in one week. Foveal avascular zone was basically stable before and after surgery. Main parameters and intraoperative perfusion of phacoemulsification surgery may not be the key factors affecting macular hemodynamics.

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Advances of optical coherence tomography in myopia and pathologic myopia

Abstract: The natural course of high-axial myopia is variable and the development of pathologic myopia is not fully understood.

Cited by 74 publications

References 104 publications

Imaging in myopia: potential biomarkers, current challenges and future developments

Imaging in myopia: potential biomarkers, current challenges and future developments

Optical coherence tomography angiography of myopic choroidal neovascularisation

Optical coherence tomography angiography evaluation of the effects of phacoemulsification cataract surgery on macular hemodynamics in Chinese normal eyes

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