Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Zha, Yi; Zhuang, Jinfei; Lin, Da; Feng, Wangqiang; Zheng, Hao; Cai, Jianqiu

doi:10.3892/etm.2017.4820

Cited by 21 publications

(18 citation statements)

References 26 publications

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“…10 In a similar study from China by Zha et al on 271 subjects, the average RNFL thickness was lower in high myopia group (90.57 ± 10.07 μm) than in low (101.46 ± 7.95 μm) and moderate myopia group (99.15 ± 8.94 μm). 11 The average RNFL thickness in all three groups in these studies were less than ours, but the differences between the three were similar. Kim et al measured peripapillary RNFL thickness in 48 myopic subjects using Stratus OCT.…”

Section: Discussioncontrasting

confidence: 37%

Retinal Nerve Fiber Layer Measurements in Myopes as Determined by Optical Coherence Tomography

M¹,

Chopra²,

Batra³

2019

jebmh

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BACKGROUND Myopia is a common cause of visual disability throughout the world. One of the potentially blinding ocular diseases associated with myopia is glaucoma. Due to similar features of the optic disc in glaucoma and myopia, there may be a misdiagnosis of glaucoma in these individuals. Decrease in retinal nerve fiber layer (RNFL) thickness as measured by optical coherence tomography (OCT) is a sensitive indicator of early glaucomatous damage. However, it remains unclear if RNFL thickness varies with refractive status of the eye. We wanted to compare retinal nerve fiber layer thickness in low, moderate and high myopia patients and study the association between retinal nerve fiber layer thickness, axial length and myopic spherical equivalent. METHODS A total of 150 eyes of 150 subjects with varying degree of myopia presenting to the Department of Ophthalmology, Christian Medical College and Hospital, Ludhiana were included in the study group. Comprehensive ophthalmic examination was performed which included visual acuity, refraction by autorefractometer, axial length by NIDEK AL-SCAN and retinal nerve fiber layer thickness by optical coherence tomography (NIDEK RS 3000 LITE). RESULTS The average (360°) RNFL thickness was significantly lower in the high myopia group as compared to the low and moderate myopia groups (p < 0.0001). On quadrant wise analysis, the RNFL was thicker in the low myopia group than in the moderate and high myopia groups in the superior, nasal and inferior quadrants (p < 0.0001, p<0.0001 and p-0.0002 respectively). However, the RNFL thickness in the temporal quadrant was comparable in the three groups (p = 0.768). CONCLUSIONS Retinal nerve fiber layer thickness decreases as the spherical equivalent and axial length increases. Therefore, this profile should be taken into consideration while analysing RNFL thickness for glaucoma evaluation in subjects with highly myopia.

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Section: Discussioncontrasting

confidence: 37%

Retinal Nerve Fiber Layer Measurements in Myopes as Determined by Optical Coherence Tomography

M¹,

Chopra²,

Batra³

2019

jebmh

View full text Add to dashboard Cite

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“…7,36 Taken together, the different influences of refractive parameters on RNFL versus macular analyses may account for the fact there is an overwhelming majority of reports focusing on refractivedependent influences in RNFL analysis, with a paucity of reports focusing on macular analysis. 7,10,16,19,22,32,33,37 This study has several limitations. Despite its prospective design, the number of enrolled participants is relatively small.…”

Section: Discussionmentioning

confidence: 97%

The effect of contact lens wear on retinal spectral domain optical coherence tomography

Aviram

Beeri

Berkow

et al. 2020

Clinical and Experimental Optometry

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Background: This study assessed the impact of contact lens wear on retinal spectral domain optical coherence tomography (SD-OCT) image quality and macular thickness measurements, among subjects with myopia. Methods: This was a prospective study including 34 subjects (26.59 AE 3.19 years) with myopia or myopic astigmatism. Twelve were imaged wearing spherical soft contact lenses, eight non-contact lens wearers were imaged with a plano soft contact lens, and 14 with significant astigmatism were fitted with a rigid gas permeable (RGP) contact lens. For each group of contact lens types, the average image quality index (Q-index), and the average macular thickness measurements were compared between macular OCT scans obtained from the same eyes with and without a contact lens. Results: Among the subjects assessed with their habitual spherical soft lenses, the average Q-index was similar for scans acquired with and without a contact lens (30.10 AE 1.94 versus 31.03 AE 2.55; p = 0.18). Among non-contact lens wearers, the average Q-index was slightly higher for scans acquired without a contact lens, compared to scans with a plano contact lens (31.99 AE 2.06 versus 29.51 AE 1.56; p = 0.006). Among 14 subjects imaged wearing a fitted RGP contact lens, the Q-index was similar for scans acquired with and without a contact lens (29.04 AE 2.73 versus 28.75 AE 2.86; p = 0.78). In all groups, there were no correlations between the power of the sphere and change in the Q-index (that is, post-minus pre-contact lens Q-index), and no differences were found between OCT-derived macular thickness measurements from scans with and without a contact lens. The magnitude of cylinder was not correlated with the change in the Q-index in the habitual and RGP contact lens groups. However, an inverse correlation between cylinder power and change in the Qindex was found in the plano contact lens group. Conclusion: In low to intermediate levels of myopia, with or without regular astigmatism, macular SD-OCT imaging does not merit placement of a soft or rigid contact lens, nor is there an added benefit from removing a habitual spherical soft lens prior to scanning.

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“…Our data is comparable to Yi Zha's study in terms of mean RNFL thickness values and comparison results between these groups. 5 Kamath et al studied RNFL thickness in myopia. They classified myopia into 3 groups, low myopia (<-3DS), median myopia (-3DS to -6DS) and high myopia (>-6DS).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Retinal Nerve Fiber Layer Thickness Between Emmetropes and High Myopes

Yadav¹

2019

IJMBS

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Background: The present study aims to compare RNFL thickness of high myopes of > - 6D and compare with emmetropic patients, so as to interpret and distinguish the physiological changes of high myopia from accompanying diseases in such individuals. Methods: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction and visual field analysis. Optical coherence tomography was used for RFNL thickness measurement. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance. Results: The mean value of average RNFL thickness in both groups was found to be 85.40 in group 1 and 99.34 in group 2. P value was 0.0001, showing that there was significant statistical difference between both the groups and average RNFL thickness was thinner in myopic group. Conclusion: RNFL was found to be significantly thin in high myopia. Keywords: RNFL thickness, Myopia, Emmetropes

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Evaluation of myopia on retinal nerve fiber layer thickness measured by Spectralis optical coherence tomography

Cited by 21 publications

References 26 publications

Retinal Nerve Fiber Layer Measurements in Myopes as Determined by Optical Coherence Tomography

Retinal Nerve Fiber Layer Measurements in Myopes as Determined by Optical Coherence Tomography

The effect of contact lens wear on retinal spectral domain optical coherence tomography

Comparison of Retinal Nerve Fiber Layer Thickness Between Emmetropes and High Myopes

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