Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes

Ascaso, Francisco J.; Rodríguez‐Jiménez, Roberto; Cabezon, L; López-Antón, Raúl; Santabárbara, Javier; Cámara, Concepción de la; Modrego, Pedro J.; Quintanilla, Miguel; Bagney, Alexandra; Gutiérrez, Letícia Gutiérrez de; Cruz, N; Cristobal, Ja; Lobò, Antonio

doi:10.1016/j.psychres.2015.07.028

Cited by 91 publications

(82 citation statements)

References 47 publications

(58 reference statements)

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“…13 Şizofreni hastalarında RSL'nin tüm kadranlarının daha ince olduğu bildirilmiştir. Bu araştırmayı izleyen diğer araştırmacılar da, benzer sonuçları bildirmişlerdir.…”

Section: Discussionunclassified

“…Örneğin, yeni geçirilen psikotik atağın neden olduğu, inflamatuvar düzenekler nedeni ile gelişen ödemin, retina tabaka kalınlığının azalmasını geçici olarak maskelediğini ve hastalık kronikleştikçe retina tabaka kalınlığının azalacağını öne sürül-müştür. 13 Her ne kadar çalışmamızda iç görü ile retina katman kalınlığı arasında sadece PNSÖ'-nün iç görüyü değerlendiren maddesinden alınan puanı arasında korelasyon bulunsa da, iç görüsü olmayan şizofreni hasta grubunun daha ince bir retina katmanlarına sahip olduğu araştır-mamızın sonuçlarında görülmektedir. İç görü-süzlüğe neden olan nörodejenerasyon, retina katman kalınlıkları içinde özellikle GHIP tabakasında incelme ile kendini gösteriyor olabilir.…”

Section: Discussionunclassified

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Decreases in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in schizophrenia, relation to insight: a controlled study

Delibaş¹,

Kartı²,

Erdoğan³

et al. 2017

Anadolu Psikiyatri Derg

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“…13 Şizofreni hastalarında RSL'nin tüm kadranlarının daha ince olduğu bildirilmiştir. Bu araştırmayı izleyen diğer araştırmacılar da, benzer sonuçları bildirmişlerdir.…”

Section: Discussionunclassified

Decreases in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in schizophrenia, relation to insight: a controlled study

Delibaş¹,

Kartı²,

Erdoğan³

et al. 2017

Anadolu Psikiyatri Derg

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“…Macular thinning and reduced MV are another reported, yet debated, finding in patients with schizophrenia compared with age-matched controls. Whereas several studies observed overall macular thinning in patients compared with age-matched controls, 61,62,75,79,80 one study observed macular thinning isolated to the nasal and inferior outer macular regions. 81 In contrast, Silverstein and colleagues reported no difference in macular thinning between schizophrenia patients and age-matched controls.…”

Section: Oct In Schizophreniamentioning

confidence: 98%

“…61,62,[72][73][74] Specifically, peripapillary RNFL thinning has been observed in the nasal, inferior and, predominately, in the superior quadrants ( Figure 2). [74][75][76][77] In contrast, Silverstein and colleagues reported no difference in RNFL thickness between schizophrenia patients and controls, 78 and Ascaso and colleagues found these significant differences only amongst right eyes, the clinical relevance of which remains unclear ( Table 1). Macular thinning and reduced MV are another reported, yet debated, finding in patients with schizophrenia compared with age-matched controls.…”

Section: Oct In Schizophreniamentioning

confidence: 99%

Retinal correlates of psychiatric disorders

Almonte

Capellàn

Yap

et al. 2020

Therapeutic Advances in Chronic Disease

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Diagnosis and monitoring of psychiatric disorders rely heavily on subjective selfreports of clinical symptoms, which are complicated by the varying consistency of accounts reported by patients with an impaired mental state. Hence, more objective and quantifiable measures have been sought to provide clinicians with more robust methods to evaluate symptomology and track progression of disease in response to treatments. Owing to the shared origins of the retina and the brain, it has been suggested that changes in the retina may correlate with structural and functional changes in the brain. Vast improvements in retinal imaging, namely optical coherence tomography (OCT) and electrodiagnostic technology, have made it possible to investigate the eye at a microscopic level, allowing for the investigation of potential biomarkers in vivo. This review provides a summary of retinal biomarkers associated with schizophrenia, bipolar disorder and major depression, demonstrating how retinal biomarkers may be used to complement existing methods and provide structural markers of pathophysiological mechanisms that underpin brain dysfunction in psychiatric disorders.

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“…Besides this, hypertension and diabetes, which often co-occur with schizophrenia and are commonly inadequately managed, can independently cause retinal thinning (Silverstein et al 2017). It has also been proposed that acute psychosis is in correlation with inflammation and tissue swelling, which can disable the detection of retinal atrophy (Ascaso et al 2015). Furthermore, the cup-to-disc ratio was enlarged and associated with cognitive symptoms in patients with schizophrenia, which seems to be mediated by RNFL thinning, loss of retinal capillaries and an enlarged optic nerve (Geyman et al 2017).…”

Section: Structural and Functional Considerations Of The Retinamentioning

confidence: 99%

New Insights Into Schizophrenia: A Look at the Eye and Related Structures

et al. 2020

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Background: Schizophrenia is a multifactorial neurodevelopmental disorder associated with cognitive dysfunction and changes in primary sensory processing. This article aims to explore the current insights into the relationship between schizophrenia and different visual disturbances.Methods: To provide a literature review of visual impairments in schizophrenia, we performed a PubMed/MEDLINE and Scopus search to identify all articles in English on the topic up to the end of 2018.Results: Multiple retinal functional and structural abnormalities are found in patients with schizophrenia. Wider retinal venules suggest chronically insufficient brain supply of oxygen and this could contribute to the occurrence of psychotic symptoms. Optical coherence tomography studies showed that retinal nerve fiber layer, macular thickness, and macular volume were significantly lowered in the chronic phase of schizophrenia. Results from electroretinogram recordings have demonstrated different declinations such as abnormalities of a -wave activity in the photoreceptors or b -wave activity in the bipolar and Muller cells. Abnormalities in eye movements, such as a notable decrease in saccades and smooth pursuit eye movements, are one of the most reliable and reproducible impairments associated with schizophrenia. Disrupted visual processing of the magnocellular pathway may result in a decrease of contrast sensitivity, sensory processing, orientation discrimination, visual integration, trajectory and spatial localization, backward masking and motion tracking. Visual perceptual abnormalities occur in more than 60% of schizophrenic patients and these are visual hallucinations, perceptual distortion of colors, shapes and light intensity, decrease in contour integration and surround suppression. Other, frequently present eye disorders include impaired visual acuity, strabismus and nystagmus.Conclusion: Visual impairments are one of the most important features of schizophrenia, which could help in defining the disease state and assigning appropriate treatment.

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Retinal nerve fiber layer and macular thickness in patients with schizophrenia: Influence of recent illness episodes

Cited by 91 publications

References 47 publications

Decreases in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in schizophrenia, relation to insight: a controlled study

Decreases in retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in schizophrenia, relation to insight: a controlled study

Retinal correlates of psychiatric disorders

New Insights Into Schizophrenia: A Look at the Eye and Related Structures

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