Retinal ependymoma: an immunohistologic and ultrastructural study

Tay, Adriel You Wei; Scheithauer, Bernd W.; Cameron, J. Douglas; Myhre, Mickey; Boerner, M.J.

doi:10.1016/j.humpath.2008.06.028

Cited by 9 publications

(8 citation statements)

References 29 publications

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“…18 However, differential diagnosis of retinal gliosis includes rare retinal glial neoplasms, most of which are associated with inherited syndromes like pilocytic astrocytoma in neurofi bromatosis type 1 and subependymal giant cell astrocytoma in tuberous sclerosis complex, to note the most siginifi cant ones. 19 Even rarer tumors are diffuse astrocytomas of acquired nature and conventional histopathology. 19 The last one glial neoplasm in frequency is ependymoma with only few cases reported.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…19 Even rarer tumors are diffuse astrocytomas of acquired nature and conventional histopathology. 19 The last one glial neoplasm in frequency is ependymoma with only few cases reported. 19 However, retinal ependymoma is considered in differential diagnosis particularly due to hyalinized vessels that could occur in both of lesions but with distinctive morphology.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…19 The last one glial neoplasm in frequency is ependymoma with only few cases reported. 19 However, retinal ependymoma is considered in differential diagnosis particularly due to hyalinized vessels that could occur in both of lesions but with distinctive morphology. 19 In my cases, hyalinized vessels of massive retinal gliosis could have been reminiscent of hyalinized vessels of ependymoma but on closer inspection eventuality of ependymoma was excluded.…”

Section: Differential Diagnosismentioning

confidence: 99%

“…19 However, retinal ependymoma is considered in differential diagnosis particularly due to hyalinized vessels that could occur in both of lesions but with distinctive morphology. 19 In my cases, hyalinized vessels of massive retinal gliosis could have been reminiscent of hyalinized vessels of ependymoma but on closer inspection eventuality of ependymoma was excluded. Massive retinal gliosis (MRG) should be differentiated from vasoproliferative tumor of the retina and acquired retinal hemangiomas, all of which could be different phenotypically reactive lesions along a spectrum of the same disease process.…”

Section: Differential Diagnosismentioning

confidence: 99%

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Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

Wincewicz¹,

Urbaniak-Wasik²,

Urbaniak³

et al. 2018

Folia Medica

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This paper presents a review on retinal gliosis illustrated by series of three cases of patients (a 39-year-old man and a 35-year-old woman with massive retinal gliosis (MRG) and a 51-year-old man with truly focal nodular gliosis of retina) with intraocular tumor-like masses and loss of vision, who recently suffered from painful inflammation of eyeball and who classically had a history of remote ocular trauma, onset of blindness early in lifetime or gradual but progressive loss of sight. The diagnosis of this pathological entity is given for the lesions that are composed of GFAP strongly positive, elongated, fusiform cells consistent with fibrillary astrocytes. As illustrated in cases from our pathological practice, PAS gave positive patchy disseminated reaction in form of cellular densely purplish granules in minority of cells representing glycogen storing. This feature could be consistent with PAS-positive Müller cells that also constitute retinal gliosis as one of cellular components of normal retina that is induced to reactive proliferation. Thus, the paper presents histological background and differential diagnosis of the entity.

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Section: Differential Diagnosismentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

See 2 more Smart Citations

Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

Wincewicz¹,

Urbaniak-Wasik²,

Urbaniak³

et al. 2018

Folia Medica

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“…[11][12][13][14][15][16] Retinal ependymomas are extremely rare, and to the best of our knowledge, only 2 cases have been reported in the literature so far. 17,18 Muller cells are specialized cells in the retina and are believed to be the progenitor cells that may give rise to intraocular glial tumors, including ependymomas. 19,20 We report herein the third case in the literature of a retinal ependymoma.…”

Section: Introductionmentioning

confidence: 99%

Intraocular Ependymoma With Blood-Filled Spaces: Neoplasm or a Reactive Process With Ependymal Differentiation—A Dilemma

et al. 2017

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Intraocular glial lesions are rare and include retinal gliosis, hamartomas, and astrocytomas and rarely ependymomas. Ependymomas are slow-growing glial tumors preferentially arising in the central nervous system (CNS), occasionally presenting at sites outside the CNS, with only 2 cases of primary retinal ependymoma reported till date. We report herein the third such case of a 20-year-old male who presented with a painful blind eye. The enucleated specimen showed presence of a glial tumor with cells arranged in sheets as well as few true rosettes and pseudo-rosettes and an immunohistochemical profile similar to a classical ependymoma at usual sites in the CNS. Additionally, the presence of blood-filled spaces and few proliferating blood vessels made it a diagnostic challenge. All retinal glial lesions are positive for GFAP and S100. Therefore, immunostaining for EMA as well as the MIB-1-labeling index maybe vital in differentiating ependymomas from other intraocular glial lesions.

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Ophthalmic Manifestations

Agrawal¹,

Fulton²

2010

Tuberous Sclerosis Complex

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Retinal ependymoma: an immunohistologic and ultrastructural study

Cited by 9 publications

References 29 publications

Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

Review on Retinal Gliosis Illustrated with a Series of Massive Glioses and Focal Nodular Gliosis Cases in Regard to Potential Pitfalls of Ocular Reactive Tumor-like Lesions of this Type

Intraocular Ependymoma With Blood-Filled Spaces: Neoplasm or a Reactive Process With Ependymal Differentiation—A Dilemma

Ophthalmic Manifestations

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